Ask about this productRelated genes to: Cpne5 antibody
- Gene:
- CPNE5 NIH gene
- Name:
- copine 5
- Previous symbol:
- -
- Synonyms:
- CPN5, COPN5, KIAA1599
- Chromosome:
- 6p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1999-02-09
- Date modifiied:
- 2016-01-26
Related products to: Cpne5 antibody
Related articles to: Cpne5 antibody
- Evidence for the microbiome's role in human health and disease has been piling up ever since the human microbiome project. The composition of one's microbiome can have a major effect on one's risk of developing cancer and the nature of how cancer develops. Several estimates suggest the percentage of cancer cases that can be attributed to microorganisms at around 15%. In addition, researchers are still trying to figure out how the microbiota, and the gut microbiota in particular, affects how a patient responds to chemotherapy, immunotherapy, and radiotherapy. In this light, we conducted an in-depth bioinformatics analysis of the gut microbiota- RCCstem cells axis, utilizing python-based programme and enrichment databases to analyses data from many sources, including clinical data, transcription factors, kinases and gene expression profile of RCCstem cells. Five genes, including SLC16A6, CPNE5, AFAP1L1, SCARF1, and NOTCH4, were shown to be shared by the hub gut microbiota and extracellular proteins. Patients with RCCstem cells had a disproportionately high number of certain types of bacteria. In patients expression profile have high CPNE5, AFAP1L1, SCARF1, and NOTCH4 expression. RCCsurvival rates are reduced by roughly 50% due to all of the genes involved. Also, the Actinobacteria and Gammaproteobacteria possible role in renal cancer development via relation to cancer stem cells. The gut microbiota and its components were considered for their possible relevance in the development of RCC. - Source: PubMed
Publication date: 2025/12/09
Alimoradi EhsanHashemnejad Mohammad AminEtemad SarehArabi MaryamBereimipour Ahmad - Vascular leakage is a major cause of multiple organ failure and mortality in sepsis, and factors that regulate endothelial integrity could serve as promising biomarkers of septic shock development. Copine family members (CPNEs) are well-characterized as soluble membrane-binding proteins, whether CPNEs play a critical role in maintaining vascular integrity during sepsis, however, remains unclear. - Source: PubMed
Publication date: 2025/11/19
Pan MingliangLi ZhixinWang XiaohongYang TianyuanLi JingqiHuang WeiFan HongkuanKesten Nebahat EcePeng TianqingZhan LiyingFan Guo-Chang - CPNE5, a member of the Copine family, is characterized by its membrane-binding properties and functions as a regulatory modulator of intracellular signaling through the spatial redistribution of interacting protein partners. Emerging evidence has demonstrated that CPNE3 exerts cardioprotective effects via anti-apoptotic activity in myocardial ischemia-reperfusion injury models. However, the functional role of CPNE5 in cardiac pathology remains unclear. In this study, the cardiac-specific overexpression of CPNE5 in mice improved cardiac function, reduced cellular apoptosis, and attenuated cardiac fibrosis in both transverse aortic constriction and ischemia-reperfusion models. Conversely, CPNE5 knockout mice exhibited opposite pathological phenotypes. Mechanistic studies revealed that CPNE5 retains FAS within the endoplasmic reticulum and promotes its degradation through the ER-phagy pathway. This process involves CPNE5's interaction with the autophagy marker LC3 and CALCOCO1, a key receptor in the ER-lysosome-associated degradation (ERLAD) pathway. Collectively, these findings indicate that CPNE5 overexpression protects cardiomyocytes against FASL-induced apoptosis under stress and ischemic conditions. - Source: PubMed
Publication date: 2025/08/06
Zhao TingtingBai YangjinmingFei YudongWei ZhixingYao PengchengChe QianjiZhang YichaoYan JiChen KaiyanWu ZhengyangQiu JunhaoWang YuepengLi WeiWang QianLi Yigang - Excessive daytime sleepiness (EDS), influenced by environmental and social-behavioral factors, is reported by a subset of patients with sleep apnea-a group that may be at elevated cardiovascular risk. However, it is unclear whether sleep apnea with and without EDS have distinct genetic underpinnings. In this study, we perform gene-by-EDS interaction analyses for apnea hypopnea index, a diagnostic marker of sleep apnea severity, to understand EDS's influence on its underlying genetic risk. - Source: PubMed
Nagarajan PavithraKurniansyah NuzululLee JiwonGharib Sina AXu YushanZhang YiyanSpitzer BrianFaquih TariqZhou HufengBoerwinkle EricChen HanGottlieb Daniel JGuo XiuqingHeard-Costa Nancy LHidalgo Bertha ALevy DanielLiu Peter YMei HaoMontalvan RebeccaMukherjee SutapaNorth Kari EO'Connor George TPalmer Lyle JPatel Sanjay RPsaty Bruce MPurcell Shaun MRaffield Laura MRich Stephen SRotter Jerome ISaxena RichaSmith Albert VStone Katie LZhu Xiaofeng Cade Brian ESofer TamarRedline SusanWang Heming - Ding'an (DA) pig, a native Chinese breed, is renowned for its excellent meat quality, disease resistance, high reproductive performance, and adaptability. Its meat quality traits hold significant economic value. However, its conservation population has been declining due to the impact of commercialized breeds and African swine fever, which is not conducive to its development and utilization. - Source: PubMed
Publication date: 2025/03/31
Wang ZiyiPan DeyouXie XinfengZhong ZiqiWang FengXiao Qian