Ask about this productRelated genes to: ARHGAP20 antibody
- Gene:
- ARHGAP20 NIH gene
- Name:
- Rho GTPase activating protein 20
- Previous symbol:
- -
- Synonyms:
- KIAA1391
- Chromosome:
- 11q22.3-q23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-05
- Date modifiied:
- 2018-02-13
Related products to: ARHGAP20 antibody
Related articles to: ARHGAP20 antibody
- To investigate the biological behavior, differentiation ability, and differential gene expression of lymph node mesenchymal stem cells (MSCs) in patients with diffuse large B-cell lymphoma (DLBCL) and reactive lymphoid hyperplasia (RLH), providing a theoretical basis for clinical chemotherapy resistance. - Source: PubMed
Ma Yu-ShuoLiu Zhi-HeSun YangZhang Yu-HangWang Wen-QiuWang Li-ShengZhao Xia - To investigate the targets and mechanisms of 7-hydroxyethyl chrysin (7-HEC) in prevention and treatment of high-altitude cerebral edema (HACE) in rats. - Source: PubMed
Zhang DongmeiLi XiaolinYang ChenyuJing LinlinHe LeiMa Huiping - Circular RNAs (circRNAs) have emerged as critical regulators of biological processes, but their roles in avian muscle development remain less explored. Here we characterize circMKNK2, a novel circRNA derived from the MKNK2 gene, which is highly expressed in slow-growing Silky chickens compared to fast-growing broilers. Functional studies demonstrate that circMKNK2 acts as a sponge for miR-15a, with overexpression inhibiting myoblast proliferation, differentiation, apoptosis, and glucose metabolism, while miR-15a knockdown produces similar effects except for enhanced glucose uptake. RNA-seq analysis identified 2189 differentially expressed genes regulated by circMKNK2 in chicken primary myoblasts, including key targets of the circMKNK2/miR-15a axis such as PIK3R1 (a core node regulating PI3K-Akt signaling), BHLHE41, KANK1, and ARHGAP20. Pathway analysis revealed modulation of myogenesis through Calcium signaling pathway, ECM-receptor interaction, Neuroactive ligand-receptor interaction and immune-related pathways (Toll-like receptor, cytokine-cytokine receptor interactions). Further analysis highlighted the circMKNK2/miR-15a axis's role in suppressing myogenesis through transcriptional regulation of key factors (e.g., SOX7, MAF) and metabolic reprogramming. Unlike pro-myogenic circRNAs, circMKNK2 uniquely inhibited muscle development and glucose metabolism, suggesting its involvement in breed-specific phenotypic differences. This study provides insights into circRNA-mediated regulation of muscle biology and offers potential targets for improving poultry production through genetic and metabolic modulation. - Source: PubMed
Publication date: 2025/05/14
Li HuihongZhang LinJiao JingyaZhang HuaiyongSi XuemengHuang YanqunChen Wen - To investigate the role of Rho GTPase-activating protein 21 (ARHGAP21) in regulating the migration and metastasis of non-small cell lung cancer (NSCLC) cells. - Source: PubMed
Xie ZLiu LFang JZhong XLin JChen F - Ewe productivity is a composite and maternal trait that is considered the most important economic trait in sheep meat production. The objective of this study was the application of alternative genome-wide association study (GWAS) approaches followed by gene set enrichment analysis (GSEA) on the ewes' genome to identify genes affecting pregnancy outcomes and lamb growth after parturition in Iranian Baluchi sheep. Three maternal composite traits at birth and weaning were considered. The traits were progeny birth weight, litter mean weight at birth, total litter weight at birth, progeny weaning weight, litter mean weight at weaning, and total litter weight at weaning. GWASs were performed on original phenotypes as well as on estimated breeding values. The significant SNPs associated with composite traits at birth were located within or near genes , , , , , and . Identified genes and pathways have functions related to pregnancy, such as autophagy in the placenta, progesterone production by the placenta, placental formation, calcium ion transport, and maternal immune response. For composite traits at weaning, genes (, , , , , , , and ) and pathways affecting feed intake and food conservation, development of mammary glands cytoskeleton structure, and production of milk components like fatty acids, proteins, and vitamin B-12, were identified. The results show that calcium ion transport during pregnancy and feeding lambs by milk after parturition can have the greatest impact on weight gain as compared to other effects of maternal origin. - Source: PubMed
Publication date: 2021/07/28
Esmaeili-Fard Seyed MehdiGholizadeh MohsenHafezian Seyed HasanAbdollahi-Arpanahi Rostam