Ask about this productRelated genes to: ELMOD1 antibody
- Gene:
- ELMOD1 NIH gene
- Name:
- ELMO domain containing 1
- Previous symbol:
- -
- Synonyms:
- DKFZp547C176
- Chromosome:
- 11q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-08-20
- Date modifiied:
- 2019-02-20
Related products to: ELMOD1 antibody
Related articles to: ELMOD1 antibody
- Novel biomarkers are needed to better identify-and distinguish-heart failure with preserved ejection fraction (HFpEF) from other clinical phenotypes. The goal of our study was to identify epigenetic-sensitive biomarkers useful to a more accurate diagnosis of HFpEF. We performed a network-oriented genome-wide DNA methylation study of circulating CD4 T lymphocytes isolated from peripheral blood using reduced representation bisulfite sequencing (RRBS) in two cohorts (i.e., discovery/validation) each of both male and female patients with HFpEF (n = 12/10), HF with reduced EF (HFrEF; n = 7/5), and volunteers lacking clinical evidence of HF (CON; n = 7/5). RRBS is the gold-standard platform for measuring genome-wide DNA methylation changes at single-cytosine resolution in hypothesis-generating studies. We identified three hypomethylated HFpEF-specific differentially methylated positions (DMPs) associated with FOXB1, ELMOD1, and DGKH genes wherein ROC curve analysis revealed that increased expression levels had a reasonable diagnostic performance in predicting HFpEF (AUC ≥ 0.8, p < 0.05). Network analysis identified additional three genes including JUNB (p = 0.037), SETD7 (p = 0.003), and MEF2D (p = 0.0001) which were significantly higher in HFpEF vs. HFrEF patients. ROC curve analysis showed that integrating the functional HFPEF classification with the expression levels of the FOXB1, ELMOD1, and DGKH as well as the JUNB, SETD7, and MEF2D genes improved diagnostic accuracy, with AUC = 0.8 (p < 0.0001) as compared to HFPEF score alone (p > 0.05). Besides, increased expression levels of SETD7-RELA-IL6 axis significantly discriminated overweight/obese HFpEF vs. HFrEF patients (AUC = 1; p = 0.001, p = 0.006, p = 0.006, respectively). We support an emerging dogma that indirect epigenetic testing via high-resolution RRBS methylomics represents a non-invasive tool that may enable easier access to both diagnostic and mechanistic insights of HFpEF. An epigenetic-oriented dysregulation of network-derived SETD7-RELA-IL6 axis in circulating CD4 T lymphocytes may drive pro-inflammatory responses which, in turn, may lead to cardiac remodeling in overweight/obese HFpEF. - Source: PubMed
Publication date: 2024/12/27
Benincasa GiudittaPepin Mark ERusso VincenzoCacciatore FrancescoD'Alto MicheleArgiento PaolaRomeo EmanueleChiappetti RosariaLaezza NunziaWende Adam RSchiattarella Gabriele GCoscioni EnricoLa Montagna AntoniettaAmarelli CristianoMaiello CiroGolino PaoloCondorelli GianluigiNapoli Claudio - Chronic kidney disease, which is defined by a reduced estimated glomerular filtration rate and albuminuria, imposes a large health burden worldwide. Ethnicity-specific associations are frequently observed in genome-wide association studies (GWAS). This study conducts a GWAS of albuminuria in the nondiabetic population of Taiwan. - Source: PubMed
Publication date: 2023/07/12
Yang Wei-ShunChuang Gwo-TsannChe Tony Pan-HouChueh Li-YunLi Wen-YiHsu Chih-NengHsiung Chia-NiKu Hsiao-ChiaLin Yi-ChingChen Yi-ShunHee Siow-WeyChang Tien-JyunChen Shiau-MeiHsieh Meng-LunLee Hsiao-LinLiao Karen Chia-WenShen Chen-YangChang Yi-Cheng - The correct intraflagellar transport (IFT) assembly at the ciliary base and the IFT turnaround at the ciliary tip are key for the IFT to perform its function, but we still have poor understanding about how these processes are regulated. Here, we identify WDR31 as a new ciliary protein, and analysis from zebrafish and reveals the role of in regulating the cilia morphology. We find that loss of WDR-31 together with RP-2 and ELMD-1 (the sole ortholog ELMOD1-3) results in ciliary accumulations of IFT Complex B components and KIF17 kinesin, with fewer IFT/BBSome particles traveling along cilia in both anterograde and retrograde directions, suggesting that the IFT/BBSome entry into the cilia and exit from the cilia are impacted. Furthermore, anterograde IFT in the middle segment travels at increased speed in Remarkably, a non-ciliary protein leaks into the cilia of , possibly because of IFT defects. This work reveals WDR31-RP-2-ELMD-1 as IFT and BBSome trafficking regulators. - Source: PubMed
Publication date: 2023/05/19
Cevik SebihaPeng XiaoyuBeyer TinaPir Mustafa SYenisert FerhanWoerz FranziskaHoffmann FelixAltunkaynak BetulPir BetulBoldt KarstenKaraman AsliCakiroglu MirayOner S SadikCao YingUeffing MariusKaplan Oktay I - - Source: PubMed
Turn Rachel EHu YihanDewees Skylar IDevi NarraEast Michael PHardin Katherine RKhatib TalaLinnert JoshuaWolfrum UweLim Michael JCasanova James ECaspary TamaraKahn Richard A - Colorectal cancer is the most common malignancy and the third leading cause of cancer-related death worldwide. This study aimed to identify potential diagnostic biomarkers for colorectal cancer by genome-wide plasma cell-free DNA (cfDNA) methylation analysis. - Source: PubMed
Publication date: 2022/01/22
Zhang XinLi TaoNiu QiangQin Chang-JiangZhang MingWu Guang-MingLi Hua-ZhongLi YanWang ChenDu Wen-FeiWang Chen-YangZhao QiangZhao Xiao-DongWang Xiao-LiangZhu Jian-Bin