Ask about this productRelated genes to: PINX1 antibody
- Gene:
- PINX1 NIH gene
- Name:
- PIN2 (TERF1) interacting telomerase inhibitor 1
- Previous symbol:
- -
- Synonyms:
- PinX1, LPTL, LPTS, FLJ20565, MGC8850, Gno1, Pxr1
- Chromosome:
- 8p23.1
- Locus Type:
- gene with protein product
- Date approved:
- 2010-04-26
- Date modifiied:
- 2019-04-16
Related products to: PINX1 antibody
Related articles to: PINX1 antibody
- RNA binding proteins (RBPs) are multi-faceted proteins that interact with transcripts in various RNA driven processes and functions. However, in situ covalent capture techniques for screening authentic RNA substrates of RBPs remain challenging in terms of reproducibility, specificity, and sensitivity. Here, we developed CuCLIP-seq (CuAAC-Crosslinking and Immunoprecipitation Sequencing), an alternative in situ covalent capture sequencing method which utilizes CuAAC reaction to crosslink RBP-RNA between azido groups of RBPs and ethynyl groups of RNA molecules, followed by streptavidin-mediated enrichment of RNA substrates and high-throughput sequencing. We demonstrate the reliability of CuCLIP-seq by identifying substrate RNAs of several RBPs, including PTBP1, ADAR2, SRSF2, HNRNPA1, and PINX1, especially for capturing low-abundance targets. Additionally, this approach is authenticated by specifically resolving the alternative splicing transcripts targeted by PTBP1 and RNA targets by PINX1. Thus, this technique offers a sensitive and specific approach for detecting RBP substrates with high reproducibility, potential scalability, and wide applicability. - Source: PubMed
Publication date: 2026/04/24
Wang XingWang Meng-KeYao Bo-FeiGao Chun-ChunJin Han-FeiChen Yu-ShengWu Er-ZhongLi AngHao Ya-JingZhao Yong-LiangYang Yun-GuiYang Ying - - Source: PubMed
Publication date: 2025/09/25
Qiu JiepingXia YingBao YaweiCheng JingjingLiu LeiQian Dong - The human liver-related putative tumor suppressor LPTS/PinX1 is a gene encoding a telomerase inhibitory protein. Overexpression of LPTS/PinX1 protein can inhibit the growth of multiple telomerase-positive cancer cell lines. LPTS/PinX1 has therapeutic potential for cancer. - Source: PubMed
Publication date: 2025/08/15
Zhou HongchangZhang XiaoyingWang YaoWu YongqiangWang LingHu ChenZhang TingZhang HuiYou DianZhao MengliZhao MujunLi AnqiChen Guangming - PIN2/TRF1-interacting telomerase inhibitor 1 (PINX1) acts as a tumor suppressor in various cancers, yet its molecular role in nasopharyngeal carcinoma (NPC) remains poorly defined. This study investigates the therapeutic potential of PINX1 in NPC. Expression levels of PINX1 and interleukin enhancer-binding factor 3 (ILF3) were assessed in NPC cells and tissues via western blotting and immunohistochemistry, and their correlation with patient prognosis was analyzed. The effects of ILF3 on NPC cell proliferation and cisplatin resistance were evaluated using cell cycle analysis, EdU incorporation, CCK-8, and IC assays. Co-immunoprecipitation and immunofluorescence confirmed the interaction between PINX1 and ILF3, while qPCR and western blotting assessed their regulatory relationship. Bioinformatics analysis, chromatin immunoprecipitation, and dual-luciferase assays were performed to identify transcription factors regulating PINX1. Additional in vitro experiments explored the antagonistic relationship between PINX1 and ILF3. Results showed that PINX1 expression was downregulated in NPC and associated with favorable prognosis, whereas ILF3 was upregulated and linked to poor outcomes. PINX1 physically interacted with ILF3 and promoted its ubiquitination through Speckle-type BTB/POZ protein (SPOP). Furthermore, signal transducer and activator of transcription 3 suppressed PINX1 transcription, while PINX1 antagonized the oncogenic effects of ILF3. Mechanistically, PINX1 facilitated ILF3 degradation via SPOP, suppressed the PI3K-AKT-mTOR pathway, inhibited tumor proliferation, and enhanced cisplatin sensitivity in NPC cells. These findings highlight the tumor-suppressive role of PINX1 and underscore its potential as a therapeutic target in NPC. - Source: PubMed
Publication date: 2025/06/15
Zhou NiGong PingguiWang ShuilianHe CuiHu LiyaPeng Hong - The receptor for hyaluronan-mediated motility (RHAMM), a centrosomal protein expressing in multiple isoforms, is implicated in telomerase-independent aging. However, its involvement in telomerase regulation is unproven. This study aims to investigate whether RHAMM correlates with telomerase activity in mammalian cells. - Source: PubMed
Publication date: 2025/06/30
Basu Kaustuv