Ask about this productRelated genes to: BIN2 antibody
- Gene:
- BIN2 NIH gene
- Name:
- bridging integrator 2
- Previous symbol:
- -
- Synonyms:
- BRAP-1
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-25
- Date modifiied:
- 2016-04-25
Related products to: BIN2 antibody
Related articles to: BIN2 antibody
- In laboratory-based diffraction contrast tomography (LabDCT), pixel binning on 2D detectors is an effective strategy to reduce exposure time and improve acquisition efficiency. However, its impact on reconstruction accuracy remains unclear. To address this, we systematically compared LabDCT datasets acquired without detector binning and with 2 × 2 binning, using synchrotron-based DCT (SRDCT) as the ground truth reference. The results show that unbinned (bin1) acquisitions yield higher grain indexing rates and improved grain boundary position accuracy compared with binned data (bin2), particularly for small grains near the sample surface. This improvement is attributed to the longer exposure time, finer spatial sampling (i.e. smaller effective pixel size), and a lower effective detection-size threshold during spot segmentation. To mitigate the information loss induced by binning, we employed a deep-learning spot-segmentation model (Mask R-CNN), which substantially improves reconstructions from binned images and narrows the performance gap relative to unbinned data. Finally, guidelines for further optimization of LabDCT acquisition and reconstruction are proposed. - Source: PubMed
Publication date: 2026/04/19
Ni XinboXia YipingFang HaixingLu JiayiLin FengxiangFan GuohuaZhang Yubin - Root developmental plasticity enables plants to adapt to nutrient-deficient conditions. Under low-nitrate (LN) conditions, enhanced exploratory root growth-characterized by increased primary and lateral root (LR) elongation-facilitates nutrient foraging. Although nitrate-hormone crosstalk regulates this process, the underlying molecular mechanisms remain poorly understood. Here, we identify the BIN2-GRF5-UBP12/13 module that governs root foraging responses to LN in Arabidopsis. We demonstrate that BIN2 phosphorylates GRF5 at Ser205, thereby reducing its stability and transcriptional activity. Integrative DAP-seq and transcriptomic analyses reveal that GRF5 directly regulates key nitrate-responsive genes, including the dual-affinity transporter gene NRT1.1 and the high-affinity uptake gene NRT2.1. Furthermore, dephosphorylated GRF5 preferentially interacts with UBIQUITIN-SPECIFIC PROTEASES 12 and 13 (UBP12/13), which stabilizes GRF5 and promotes LR elongation under LN conditions. Our findings delineate a phosphorylation-dependent regulatory circuit that fine-tunes root foraging adaptation, advancing the mechanistic understanding of nitrate sensing in plants. - Source: PubMed
Publication date: 2026/04/27
Li TaotaoYao XiuhongLiu DongxiaoKang XinkeFang KeZhao MeiZhao YuqingCai YueliSun JingjingTian WenhuiGong LupingWu ZhenjiangWei WenxiLi MengyuanLiao ChunliWang LianzheLin HonghuiZhang Dawei - Parental contributions to offspring phenotype extend beyond genetic inheritance, encompassing non-genetic factors that influence early development. However, the interplay between maternal and paternal effects remains poorly understood. This study investigates these contributions in Eurasian perch (Perca fluviatilis) - a valuable model to study parental effect in finfishes - by analyzing early life traits and transcriptomic profiles of larvae resulting from crosses between wild and domesticated parents. - Source: PubMed
Publication date: 2026/04/20
Debernardis RossellaPanda AbhipsaWałdowska SylwiaPalińska-Żarska KatarzynaKlopp Christophede Almeida Taina RochaJarmołowicz SylwiaHliwa PiotrŻarski Daniel - There is accumulating evidence suggesting an association between periodontitis (PD) and preterm birth (PTB), but the underlying mechanisms have not been fully elucidated. This study aims to explore potential biomarkers and mechanisms between PD and PTB through integrated bioinformatics and machine learning approaches. - Source: PubMed
Publication date: 2026/02/20
Mei FengLiu YutongXu WentingLiu RuoyunWang XinlinLi TingtingChen YiWu TingtingZhang Wei - Brassinosteroids (BRs) are essential phytohormones that regulate plant growth and development, including hypocotyl elongation in Arabidopsis thaliana. Although the core BR signaling components have been well characterized, the mechanisms that control the nuclear localization and stability of key transcription factors such as BZR1 and BES1 remain less understood. Here, we identify IMPORTIN BETA 4 (IMB4) as a critical regulator of BR-mediated hypocotyl elongation. Loss-of-function imb4-1 mutants exhibit reduced hypocotyl elongation in the dark and display reduced sensitivity to exogenous brassinolide and enhanced sensitivity to the BR biosynthesis inhibitor brassinazole. IMB4 physically interacts with BZR1 and BES1, promotes their nuclear accumulation, and enhances their stability by protecting them from 26S proteasome-mediated degradation. Genetic analysis shows that the bzr1-1D and bes1-1D alleles partially rescue the imb4-1 hypocotyl phenotype, and expression of BR-responsive genes is reduced in imb4-1 but restored by bzr1-1D. Mechanistically, IMB4 interferes with the interaction between BIN2 and BZR1/BES1, thereby inhibiting their degradation. Moreover, IMB4 expression is induced by BR treatment, suggesting a positive feedback loop. Our findings uncover a previously unrecognized role for IMB4 in regulating BR signaling and highlight the importance of nuclear transport machinery in hormone-mediated developmental programs. - Source: PubMed
Qin ZhengGao YangLiu YujieLi ShanweiFeng QiangnanZhang YanLi ShaXiong Feng