Ask about this productRelated genes to: BIN2 antibody
- Gene:
- BIN2 NIH gene
- Name:
- bridging integrator 2
- Previous symbol:
- -
- Synonyms:
- BRAP-1
- Chromosome:
- 12q13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-25
- Date modifiied:
- 2016-04-25
Related products to: BIN2 antibody
Related articles to: BIN2 antibody
- Clonal hematopoiesis of indeterminate potential (CHIP) is a precursor to myeloid malignancies, yet the functional proteomic landscape that governs clonal fitness and microenvironmental remodeling remains poorly understood. This systematic review consolidates high-resolution proteomic evidence to map the transition from stable CHIP to overt malignancy. - Source: PubMed
Publication date: 2026/08/27
Husein Jana HKhayata Rasha MJahangir AishaMansour Ghaith KHajjar Ahmed WSajid Muhammad Raihan - Climate change is intensifying heat, drought and salinity stresses, placing global food production at increasing risk and highlighting the need for stress-resilient crops. Brassinosteroids (BRs), key plant steroid hormones, have emerged as central regulators of growth and environmental adaptation through coordinated transcriptional, hormonal and redox-mediated responses. Recent advances have refined the classical view of BRs biology by elucidating key biosynthetic and regulatory mechanisms. At the signalling level, the BRASSINOSTEROID INSENSITIVE 1 (BRI1)-BRI1-ASSOCIATED RECEPTOR KINASE 1 (BAK1) receptor complex and the GLYCOGEN SYNTHASE KINASE 3 (GSK3)-like kinase BRASSINOSTEROID INSENSITIVE 2 (BIN2)-BRI1-EMS-SUPPRESSOR 1 (BES1)/BRASSINAZOLE-RESISTANT 1 (BZR1) transcriptional module remain core components. The discovery of ABCB-mediated BRs transport has introduced a new conceptual framework in which hormone distribution contributes to localized signalling and tissue-specific responses. BRs enhance stress tolerance by improving antioxidant defence, photosynthesis, ion homeostasis, nutrient utilization, and hormonal coordination. Genome editing and multi-omics approaches further highlight the dynamic and spatial regulation of BRs networks. This review integrates mechanistic, transport, and systems-level advances into a unified framework for climate-resilient crop improvement. - Source: PubMed
Publication date: 2026/08/24
Mane Rushikesh SanjayPrasad Bishun DeoSahni SangitaQuaiyum ZebaKanth KatyayniSingh Satish KumarSharma V K - Animal and plant stem cells have evolved lineage-specific regulatory networks over billions of years of independent evolution. However, their shared unicellular origin implies the preservation of shared ancestral regulatory modules and the repeated use of analogous molecular logic in stem cell control. Therefore, this narrative review aims to explore the molecular mechanisms common to animal and plant stem cells by focusing on three key aspects: stemness maintenance, transcriptional regulation, and metabolic control. In terms of stemness maintenance, the review highlights the pivotal functions of conserved proteins including breast cancer gene 1-associated really interesting new gene domain 1 (BARD1; animal protein)/AtROW1 (BARD1 plant homolog), retinoblastoma protein (RB; animal protein)/RETINOBLASTOMA-RELATED (RBR; RB plant homolog), and P-element induced wimpy testis (Piwi; animal protein)/ZWILLE (ZLL; Piwi plant homolog). In terms of transcriptional regulation, the review reveals the conserved functions of complexes and factors, such as Polycomb group PcG/Trithorax group proteins TrxG, switch/sucrose non-fermentable, MYC proto-oncogene (c-Myc; animal protein)/MYC (c-Myc plant homolog), Lin28/cold-shock domain protein 1, and Pumilio RNA-binding proteins in determining stem cell fate. In terms of metabolic regulation, the review delineates the convergent roles of threonine metabolism, target of rapamycin kinase signaling, glycogen synthase kinase (GSK3β; animal protein)/BRASSINOSTEROID-INSENSITIVE 2 (BIN2; GSK3β plant homolog), and nitric oxide signaling in orchestrating stem cell homeostasis by integrating nutrient and environmental signals. Despite vast differences in tissues and environments, the review findings suggest that stem cell systems across multicellular life forms share a common ancient molecular language for regulation. Overall, this review not only offers a fresh perspective on the evolution of stem cell mechanisms but also proposes testable hypotheses and conceptual frameworks for future cross-kingdom studies that may, in the long term, inform regenerative medicine research. - Source: PubMed
Publication date: 2026/08/14
Huang QiangTang Qi-ShengQi Ming-YueYang Xiao-YuXie Hong-QingGuo HuiZhang Xin-Yu - Sugar is both an essential energy source and the major substrate for cell wall biosynthesis during plant growth, yet how growth-promoting hormones regulate sugar synthesis remains unclear. Here we show that the brassinosteroids (BRs) promote gluconeogenic and photosynthetic sugar synthesis by activating phosphoenolpyruvate carboxykinase (PCK), which catalyses the conversion of oxaloacetate to phosphoenolpyruvate, a central step in primary metabolism. Arabidopsis BR-deficient mutants display reduced PCK1 activity and elevated phosphorylation at conserved Ser-62 and Thr-66 residues. BR treatment induces PCK1 dephosphorylation and activation, whereas the GSK3-like kinase BIN2 phosphorylates these sites, altering quaternary structure and inhibiting PCK1. Phospho-blocking mutations of Ser-62/Thr-66 confer BR-independent PCK1 activity and enhance seedling growth, while phosphomimetic mutations reduce PCK1 activity and impair seedling growth and establishment. BRs also promote PCK dephosphorylation and activation in photosynthetic leaves of maize and sorghum. Our study demonstrates that BRs regulate primary metabolism via GSK3/BIN2-mediated phosphorylation of PCK, thereby promoting gluconeogenesis and photosynthesis. - Source: PubMed
Publication date: 2026/08/28
Zhang HongliangAizezi YalikunjiangBessho-Uehara KanakoChaudhary AjeetTrinh Cao SonXu Shou-LingWang Zhi-Yong - Guard cell movement is orchestrated by complex internal and environmental signals, with ZmGCT1 and ZmGCT2 playing critical roles in maintaining guard cell turgor in maize. Here, we demonstrate that ZmGCT1 interacts with and inhibits ZmSK4, a GSK3-like kinase. Under drought stress, ABA-activated ZmSnRK2s phosphorylate ZmGCT1, relieving its partial inhibition of ZmSK4, which, together with the relief of ZmPP2Cs-mediated inhibition, leads to ZmSK4 activation. ZmSK4 directly phosphorylates ZmSLAC1 and activates its anion currents in Xenopus oocytes, which ultimately promotes stomatal closure under drought stress. Consistent with this mechanism, mutations in ZmSK4 and its homolog ZmSK3 not only confer drought sensitivity but also suppress the constitutively closed stomata phenotype of the Zmgct1 mutant. Notably, in contrast to its BIN2 homologs, which do not regulate stomatal movement in Arabidopsis but stomatal development, ZmSK4 and ZmSK3 do not influence stomatal development in maize. Our findings thus delineate a complete phosphorylation relay within the ABA signaling pathway that dynamically regulates stomatal movement under drought stress in maize. - Source: PubMed
Publication date: 2026/07/14
Li HuiyingFeng ZhenkaiCheng JinkuiWang YuQi JunshenSong WenYang ShuhuaGong Zhizhong