Ask about this productRelated genes to: GLOD4 antibody
- Gene:
- GLOD4 NIH gene
- Name:
- glyoxalase domain containing 4
- Previous symbol:
- C17orf25
- Synonyms:
- CGI-150, HC71
- Chromosome:
- 17p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-06-24
- Date modifiied:
- 2016-12-12
Related products to: GLOD4 antibody
Related articles to: GLOD4 antibody
- Tyrosine nitration alters the structure, function, and cellular localization of proteins and is implicated in the pathology of multiple diseases [G. Ferrer-Sueta , , 1338-1408 (2018), H. Ischiropoulos, , 1-11 (1998), I. Griswold-Prenner , , 105038-10554 (2023)]. Although protein nitration is assumed to proceed via nonspecific chemical mechanisms, it is highly selective, suggesting the possibility of enzymatic catalysis. Here, we showed that glyoxalase domain-containing protein 4 (GLOD4), a previously uncharacterized protein, is an enzyme that catalyzes selective protein nitration. A primary in vivo target for GLOD4-mediated nitration is alpha-synuclein (α-syn), which is central to the pathogenesis of Parkinson's disease (PD) and related disorders. We document tyrosine nitration of α-syn by GLOD4 in vitro, in cells, and in a murine model of synuclein pathology. The data identified a function of GLOD4 and other structurally related proteins that catalyze the peroxynitrite-mediated selective protein tyrosine nitration. This enzymatic catalysis of nitration may unearth pathophysiological mechanisms and potential interventions in diseases such as PD, cancer, and autoimmunity. - Source: PubMed
Publication date: 2026/02/02
Wright SarahDang Vu CHussain SamiKandel PrasannaBrendza Robert PMazhar SaharWhitmore MarieBoudoukha SelimKaur Banwait JaskamaljotVan Der Linden RobertVertudes EdwardMarkham KateTrzeciak MartaPohan GraceJennings AndyShahidi-Latham SheerinKayser FrankBeckstead MikeLucius Aaron LKashyap ArunIschiropoulos HarryGriswold-Prenner Irene - The causal relevance of circulating plasma protein-to-protein ratios (PPRs) in Rheumatoid Arthritis (RA) remains unclear. We employed Mendelian Randomization (MR) to investigate this relationship. - Source: PubMed
Publication date: 2025/11/14
Yan MingyueHou KehaoWang TianruiZhang Yingze - Prostatic diseases, consisting of prostatitis, benign prostatic hyperplasia (BPH), and prostate cancer (PCa), pose significant health challenges. While single-omics studies have provided valuable insights into the role of mitochondrial dysfunction in prostatic diseases, integrating multi-omics approaches is essential for uncovering disease mechanisms and identifying therapeutic targets. - Source: PubMed
Publication date: 2025/08/22
Gong BinbinYang FeixiangZhang NingWu ZhengyangLiu TianruiWang KunZhang XiangyuZhang YangyangSong ZhengyaoLiang Chaozhao - Glyoxalase domain containing protein 4 (GLOD4), a protein of an unknown function, is associated with Alzheimer's disease (AD). Three GLOD4 isoforms are known. The mechanism underlying GLOD4's association with AD was unknown. - Source: PubMed
Utyro OlgaWłoczkowska-Łapińska OlgaJakubowski Hieronim - The expression pattern of in the testis and its regulatory effect on testicular cells was explored in goats to enhance our understanding of spermatogenesis and improve reproduction in breeding rams. In this study, we demonstrated the localization of in testicular cells using immunohistochemistry and subcellular localization analyses. Subsequently, we analyzed the expression pattern in four age-based groups (0, 6, 12, and 18 months old) using real-time quantitative polymerase chain reaction (qRT-PCR) and protein blotting. Finally, we performed silencing and overexpression studies in Leydig cells (LCs) and explored the effects on cell proliferation, the cell cycle, steroid hormone secretion and the expression of candidate testosterone hormone-regulated genes. was mainly expressed in Leydig cells, and the subcellular localization results showed that the GLOD4 protein was mainly localized in the cytoplasm and nucleus. Silencing of significantly suppressed the mRNA expression levels of the testosterone secretion-related genes , , and and the mRNA expression levels of cell cycle-related genes , , and . Moreover, the cell cycle was blocked at the G2/M phase after silencing, which significantly suppressed testosterone secretion. In contrast, overexpression significantly increased the mRNA expression levels of the testosterone secretion-related genes , , and and increased the expression of the cell cycle-related genes , , and . Moreover, overexpression promoted the cell cycle from G0/G1 phases to enter the S phase and G2/M phases, promoted the secretion of testosterone. Taken together, our experimental results indicate that may affect the development of cells in Qianbei Ma goats of different ages by influencing the cell cycle, cell proliferation, and testosterone hormone synthesis. These findings enhance our understanding of the functions of in goats. - Source: PubMed
Publication date: 2024/09/08
Wang JinqianChen XiangSun WeiTang WenChen JiajingZhang YuanLi RuiyangWang Yanfei