Ask about this productRelated genes to: NOSIP antibody
- Gene:
- NOSIP NIH gene
- Name:
- nitric oxide synthase interacting protein
- Previous symbol:
- -
- Synonyms:
- CGI-25
- Chromosome:
- 19q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2003-01-06
- Date modifiied:
- 2016-10-24
Related products to: NOSIP antibody
Related articles to: NOSIP antibody
- To assess CT-to-CT angiography (CT-CTA) times at primary stroke centres (PSCs) for patients eligible for mechanical thrombectomy (MT) in acute ischaemic stroke, and to identify causes of imaging delays. - Source: PubMed
Publication date: 2026/03/16
Sarnecki TatyanaMancuso-Marcello MarcoNikola ChristosSpooner OliverBhogal Pervinder - This study aims to explore shared key genes between head and neck neoplasm (HNN) and aging. - Source: PubMed
Publication date: 2026/02/01
Sun ChenChen XinleiLi JinzhaoHu LirongShi RuiLi ChunhuiWang Canli - RNA-binding proteins (RBPs) are key regulators of cellular transcription and are associated with the occurrence and development of diseases. - Source: PubMed
Publication date: 2025/03/26
Mo Lin-JianLiang Hai-QiYu Zhen-YuanLiang Yao-WenGu Chuan-XinWei Qiu-JuHe Qi-HuanWei Fa-YeCheng Ji-WenMo Zeng-Nan - Blastocyst complementation can potentially generate a rodent model with humanized nasopharyngeal epithelium (NE) that supports sustained Epstein-Barr virus (EBV) infection, enabling comprehensive studies of EBV biology in nasopharyngeal carcinoma. However, during this process, the specific gene knockouts required to establish a developmental niche for NE remain unclear. We performed bioinformatics analyses and generated Foxa1 mutant mice to confirm that Foxa1 disruption could potentially create a developmental niche for NE. Subsequently, MYD88-inactivated human pluripotent stem cells (hPSCs) were constructed and complemented with Foxa1-deficient mouse blastocysts, with Nosip-deficient mouse blastocysts as a control. The chimerism of human cells in mouse embryos was evaluated from E8.5 to E12.5 using genomic DNA PCR and immunohistochemistry. Our bioinformatics analysis indicated that the expression patterns of Foxa1 in E8.5 to E16.5 mouse embryos underscore its critical role in NE development. The generated mice with Foxa1 disordered region mutations displayed morphological abnormality in NE, suggesting Foxa1-knockouts could potentially establish a developmental niche for NE. In chimeric assays, human cells integrated into 80.00% of Foxa1-deficient embryos, compared with the 4.17% in controls. Immunohistochemistry results revealed robust proliferation of human cells in Foxa1-deficient mouse embryos. However, chimeras from Foxa1-deficient mouse embryos did not survive beyond E10.5, hindering the evaluation of human cell integration in mouse NE. Foxa1 disruption in mouse embryos significantly enhances the integration of human cells in human-mouse interspecies chimeras, thereby facilitating the generation of endoderm-derived organs through blastocyst complementation. Overcoming chimeras' embryonic lethality is crucial for successfully generating humanized NE in Foxa1-deficient mouse embryos. - Source: PubMed
Publication date: 2024/12/21
Wang Li-NaJia Jun-ShuangYang Xing-LongWen Yue-TingLiu Jing-XianLi Deng-KeChen Xing-RuiWang Jia-HongLi Ji-KeHuang Zhong-XiYao Kai-Tai - Nitric oxide (NO) and other reactive nitrogen species (RNS) are considered to be signaling molecules in higher plants involved in the regulation of growth and development processes. However, the molecular mechanisms of their formation, removal, and participation in plant responses to adverse environmental stimuli remain largely unclear. Therefore, the aim of this study was to assess the influence of selected single stresses and combined stresses (i.e., L. aphid infestation, drought, aphid infestation, and drought) and post-stress recovery on the contents of NO and peroxynitrite anion (ONOO), as well as the levels of mRNA and protein nitration (i.e., the 8-nitroguanine and protein 3-nitrotyrosine amounts, respectively), in maize seedlings ( L.). Moreover, the expression patterns of the two tested genes (, encoding nitric oxide synthase-interacting protein, and , encoding nitrate reductase 1) involved in NO metabolism in maize plants were quantified. We identified significant intervarietal, time-course, and stress-dependent differences in the levels of the quantified parameters. Under the investigated stress conditions, the aphid-resistant Waza cv. seedlings were characterized by a higher and earlier NO accumulation and mRNA nitration level and an increased expression of the two target genes ( and ), compared to the aphid-susceptible Złota Karłowa cv. seedlings. Conversely, the Złota Karłowa plants responded with a greater elevation in the content of ONOO and protein 3-nitrotyrosine than the Waza cv. plants The multifaceted role of NO and its derivatives in maize plants challenged by single and combined stresses, as well as during post-stress recovery, is discussed. - Source: PubMed
Publication date: 2024/10/20
Sytykiewicz HubertCzerniewicz PawełRuszczyńska MagdalenaKmieć Katarzyna