Ask about this productRelated genes to: MYBPH antibody
- Gene:
- MYBPH NIH gene
- Name:
- myosin binding protein H
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 1q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-06-18
- Date modifiied:
- 2015-09-04
Related products to: MYBPH antibody
Related articles to: MYBPH antibody
- Dermatomyositis is a common immune-mediated skin disorder whose pathogenesis has not been fully elucidated. Environmental factors play a key role in its onset and progression. Bisphenol A (BPA) is a widespread environmental pollutant known to pose risks to human health. Previous studies have indicated that BPA exposure can disrupt immune function and trigger skin inflammation and autoimmune diseases. However, the role and molecular mechanisms of BPA in dermatomyositis remain unclear. This study aims to systematically elucidate whether and how bisphenol A (BPA) may contribute to the development of dermatomyositis by identifying key toxicological targets and underlying molecular mechanisms through an integrated computational framework. - Source: PubMed
Publication date: 2026/03/30
Cheng LiliTang ZhongfuLi MingHuang Chuanbing - A detailed analysis of how muscle fiber nuclei (myonuclei) respond to a hypertrophic stimulus could provide a critical step toward understanding compromised skeletal muscle plasticity with age. We used recombination-independent doxycycline-inducible myonucleus-specific fluorescent labelling, tissue RNA-sequencing, myonuclear DNA methylation analysis, multi-omic integration, and single myonucleus RNA-sequencing (smnRNA-seq) to define the molecular characteristics of adult (6-8 month) and aged (24 month) murine skeletal muscle after acute mechanical overload (MOV). In adult and aged MOV muscles, we found that: 1) similarities in the transcriptional response to loading-specifically in metabolism genes - were partly explained by a post-transcriptional microRNA-mediated mechanism that we corroborated using an inducible muscle fiber-specific miR-1 knockout model, 2) differences in age-dependent transcriptional responses were linked to the magnitude and location of differential DNA methylation in resident myonuclei, specifically around genes such as Myc, Runx1, Mybph, Ankrd1, collagen (Col) genes, and minichromosome maintenance (Mcm) genes, 3) adult and aged resident myonuclear transcriptomes had differing enrichment for innervation-related transcripts as well as unique transcriptional profiles in an Atf3+ "sarcomere assembly" population after MOV, and 4) cellular deconvolution analysis and smnRNA-seq supports a role for neuromuscular junction regulation in age-specific hypertrophic adaptation. These data are a roadmap for uncovering molecular targets to enhance aged muscle adaptability. - Source: PubMed
Publication date: 2026/02/17
Koopmans Pieter JJones Ronald GCabrera Ana ReginaMorena FranciellyGreene Nicholas PMcCarthy John JIsmaeel AhmedWen YuanMurach Kevin A - A detailed analysis of how muscle fiber nuclei (myonuclei) respond to a hypertrophic stimulus would provide a critical step toward understanding compromised skeletal muscle plasticity with age. We used recombination-independent doxycycline-inducible myonucleus-specific fluorescent labelling, tissue RNA-sequencing, myonuclear DNA methylation analysis, multi-omic integration, and single myonucleus RNA-sequencing to define the molecular characteristics of adult (6-8 month) and aged (24 month) murine skeletal muscle after acute mechanical overload (MOV). In adult and aged MOV muscles, we found that: 1) similarities in the transcriptional response to loading - specifically in metabolism genes - were partly explained by a post-transcriptional microRNA-mediated mechanism, which we corroborated using an inducible muscle fiber-specific knockout model, 2) differences in age-dependent transcriptional responses were linked to the magnitude and location of differential DNA methylation in resident myonuclei, specifically around hypertrophy-associated genes such as , , , collagen genes, and minichromosome maintenance genes, 3) adult and aged resident myonuclear transcriptomes had differing enrichment for innervation-related transcripts as well as unique transcriptional profiles in an + "sarcomere assembly" population after MOV, and 4) cellular deconvolution analysis supports a role for neuromuscular junction regulation in age-specific hypertrophic adaptation. These data are a roadmap for uncovering molecular targets to enhance aged muscle adaptability. - Source: PubMed
Publication date: 2025/10/30
Koopmans Pieter JJones Ronald GCabrera Ana ReginaMorena FranciellyGreene Nicholas PMcCarthy John JIsmaeel AhmedWen YuanMurach Kevin A - Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood. In this study we investigate the effects of MAVA across diverse cardiac models, including healthy female porcine cardiomyocytes and myocardial slices, human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), cardiac organoids and living myocardial slices (LMSs) derived from patients with HOCM. - Source: PubMed
Publication date: 2025/11/10
Kiselev ElisaAgyapong WilsonJürgens BjarneMohr ElisaChatterjee ShambhabiHunkler Hannah JSalman JawadCipriano GiuseppeBentele MarcoLiu JunqingSpecht JonasMenge Kaja SWaleczek Florian J GHaas Jonas ADerda Anselm ASonnenschein KristinaGietz AnikaNeumüller SusannePfanne AngelikaBeetz OliverPflaum MichaelWiegmann BettinaPsaras YiangosToepfer ChristopherZweigerdt RobertRadocaj AnteKraft TheresiaZeug AndrePonimaskin EvgeniKorte WilhelmHorke AlexanderRuhparwar ArjangFuchs MaximilianXiao KeBär ChristianWeber NatalieThum Thomas - Kazakh horses, a distinguished breed in China known for their dual-purpose use in milk and meat production, exhibit early maturation, tolerance to coarse feeding, and strong resistance to environmental stress. However, the gene expression differences across various muscle tissues of Kazakh horses have yet to be elucidated. In this study, transcriptomic sequencing was performed on muscle tissues from three anatomical regions of Kazakh horses, including the longissimus dorsi (Gb), external oblique (Gf), and diaphragm (Gg) muscles. In the Gb and Gf groups, 426 differentially expressed genes (DEGs) were identified, including , and , of which 147 were upregulated and 279 downregulated. In the Gf and Gg groups, 1,762 DEGs were detected, including , and , with 1,391 upregulated and 371 downregulated. Additionally, 644 DEGs were identified between the Gg and Gb groups, including , and , with 172 upregulated and 472 downregulated. GO annotation and KEGG enrichment analysis revealed that the DEGs, such as , and , were primarily involved in System Development, Extracellular Space, and Protein-Arginine Deiminase Activity. Furthermore, pathways related to skeletal muscle growth, including Cytoskeleton in Muscle Cells, Cytokine-Cytokine Receptor Interaction, and Motor Proteins, were significantly enriched. RT-qPCR analysis validated the accuracy of the transcriptomic sequencing data. This study provides valuable insights into the differential expression of genes and related signaling pathways in various muscle tissues of Kazakh horses, rendering a theoretical foundation and data references for understanding skeletal muscle growth and improving meat production in equines. - Source: PubMed
Publication date: 2025/07/24
Wubulikasimu MierkadinaLiu JiahaoYao XinkuiMeng JunWang JianwenZeng YaqiLi LinlingRen Wanlu