Ask about this productRelated genes to: PRKACB antibody
- Gene:
- PRKACB NIH gene
- Name:
- protein kinase cAMP-activated catalytic subunit beta
- Previous symbol:
- -
- Synonyms:
- PKACb
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-10-05
Related products to: PRKACB antibody
Related articles to: PRKACB antibody
- Constipation, a prevalent gastrointestinal disorder, significantly impairs quality of life. Emodin, a bioactive anthraquinone found in traditional herbal remedies like , is empirically known for its laxative effects, yet its precise molecular mechanism remains incompletely understood. This study aimed to elucidate the laxative potential of emodin and delineate its underlying mechanism, with a specific focus on the activation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. This therapeutic effect was abrogated in W1282X cystic fibrosis mice lacking functional CFTR, demonstrating CFTR-dependency. In HT-29 human colonic epithelial cells, emodin activated the CFTR chloride channel detected by a fluorescence-based membrane potential assay in a concentration-dependent manner with a half-maximal effective concentration (EC₅₀) of 10⁻⁵·⁷ M and a maximal effect reaching 68.3% of that induced by the positive control, genistein. Mechanistic investigations revealed that emodin did not alter the total protein abundance of CFTR but significantly enhanced its phosphorylation. Pharmacological inhibition of the cAMP/protein kinase A (PKA) pathway attenuated emodin-induced CFTR activation and laxative effects. Consistently, emodin upregulated the mRNA expression of key cAMP/PKA pathway components, PRKACB and CREB1. In conclusion, our findings demonstrate that emodin alleviates constipation by activating the CFTR chloride channel. This effect is mediated through the cAMP/PKA signaling pathway, which enhances CFTR phosphorylation and channel activity, thereby promoting chloride-dependent fluid secretion into the colonic lumen. This study clarifies a pivotal molecular mechanism for emodin's laxative action and supports its therapeutic potential. - Source: PubMed
Publication date: 2026/05/02
Han Shan-ShanChen QiangHuo Li-ShengTang BiaoZang Liang - Biliary atresia (BA), the most common cause of extrahepatic obstructive jaundice in infants, is a severe infant disease with a poor prognosis and unclear etiology. RNA-binding proteins (RBPs) are key regulators of alternative splicing and are implicated in various liver pathologies. However, whether RBP dysfunction and resultant aberrant splicing contribute to BA pathogenesis remains unknown. - Source: PubMed
Publication date: 2026/04/06
Cheng JiwenZhao PuCao PingHui JunPeng - Carney complex (CNC) is an autosomal dominant multiple neoplasm syndrome, characterized by the presence of endocrine and non-endocrine tumors; it includes myxomas, lentigines and primary pigmented nodular adrenocortical disease, among other signs/symptoms. In CNC type 1, inactivating mutations of the PRKAR1A gene were identified as the main cause of the disease, although since 2015 variants in other genes, including PRKACA and PRKACB, have also been linked to this pathology. PKA is an enzyme involved in the G protein-coupled intracellular pathways and serves as a mediator of c-AMP actions that promote cell metabolism, proliferation and apoptosis. The penetrance of CNC due to pathogenic variants in the PRKAR1A gene is close to 100%. We present the case of a 33-year-old female patient with cutaneous and mucosal lentiginosis, blue nevus, malignant melanocytic psammomatous schwannoma, cutaneous myxoma and a novel variant in the PRKAR1A gene. - Source: PubMed
Publication date: 2026/04/15
Vázquez Ares María JoséRolón CamilaMercado Graciela - - Source: PubMed
Publication date: 2026/04/07
Chen YongGao YingTian YeTian Da-Li - Late-life depression (LLD) with high prevalence accelerates cognitive impairment and becomes a risk factor for dementia, yet the pathogenesis of LLD is still largely unclear. Delineating the neuromolecular mechanism of LLD is of great significance to its etiology, early diagnosis, and precision treatment. - Source: PubMed
Publication date: 2026/04/16
Chen MeilingZhang HongjiangYu XiaohuiZhang JieZhong JingmeiChen KexuanZi RongWu ZheWang ZhiyuanWu KunhuaWang JiaojianShao HengZhao YingZhu Baosheng