Ask about this productRelated genes to: NPTX2 antibody
- Gene:
- NPTX2 NIH gene
- Name:
- neuronal pentraxin 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-12
- Date modifiied:
- 2016-10-05
Related products to: NPTX2 antibody
Related articles to: NPTX2 antibody
- The synaptic transmission of memory engrams is important for their roles in memory storage and retrieval, and can be regulated by multiple neuronal adhesion molecules. This study focuses on the roles of neuronal pentraxin (NPTX) family members (NPTX1 and NPTX2), which are biomarkers for cognitive decline, in the synaptic transmission of Fos-(F-RAM) and Npas4-(N-RAM)-dependent engrams formed during contextual fear conditioning in the dentate gyrus. - Source: PubMed
Publication date: 2026/05/13
Mao FeihuangYang YangJiang ZhuyingLe QiuminJin Tao - Experience reshapes cortical circuits, yet plasticity is tightly gated-high during early critical periods and increasingly constrained with maturation. Later in life, aging and Alzheimer's disease (AD) create a growing demand to restrain network hyperactivity. Across these contexts, excitatory drive onto parvalbumin-positive fast-spiking interneurons (PVs)-shaped by synaptic organizers such as NPTX2-offers a control point for tuning inhibitory tone while preserving fast, precise inhibition. We outline the cellular and synaptic specializations that make PVs powerful regulators of network excitability, then synthesize evidence from visual cortex suggesting that critical period termination reflects the loss of plasticity at principal neuron→PV inputs. Finally, we extend this framework to aging and AD, where medial temporal lobe hyperactivity and early PV dysfunction coincide with NPTX2 dysregulation, suggesting that restoring excitatory recruitment of PVs may help stabilize circuits and prevent cognitive decline. - Source: PubMed
Publication date: 2026/04/24
Severin DanielKirkwood Alfredo - Depression is a complex mental disorder that demands multi-target therapeutic strategies. The Radix Bupleuri-Radix Paeoniae Alba (CB) herb pair, a classic Traditional Chinese Medicine (TCM) formulation for "soothing the liver and relieving depression," shows clinical promise, yet its system-level mechanisms remain unclear. This study employed an integrated multi-omics approach, combining hippocampal metabolomics (UPLC/Q-TOF-MS), proteomics (TMT), and transcriptomics (RNA-seq), to elucidate the antidepressant mechanisms of CB in a chronic unpredictable mild stress (CUMS) rat model. Metabolomic analysis identified 10 differential hippocampal metabolites in depressed rats, among which CB significantly normalized five core biomarkers-creatine, xanthine, docosahexaenoic acid, arachidonic acid, and 3-O-sulfogalactosylceramide-implicating the restoration of arachidonic acid, purine, and glutathione metabolism. Integrated proteomic and transcriptomic analyses revealed that the core mechanisms involve the synergistic regulation of neuroinflammation and synaptic plasticity. CB downregulated pro-inflammatory mediators (e.g., NPTX2, TNFRSF21) while upregulating key modulators of neurotransmission (e.g., SLC6A2). Joint pathway analysis demonstrated concurrent suppression of neuroinflammatory signaling (e.g., NF-κB) and enhancement of synaptic remodeling pathways (e.g., PI3K/Akt/BDNF axis), alongside restoration of redox homeostasis (elevated GSH). This multi-omics study provides a systems-level understanding of the CB herb pair, demonstrating its coordinated action in suppressing neuroinflammation, enhancing synaptic plasticity, and rebalancing neuroendocrine and oxidative stress pathways. The findings bridge TCM theory with modern neurobiology, positioning CB as a synergistic, multi-target therapeutic candidate for depression. - Source: PubMed
Publication date: 2026/05/08
Zhang HongcaiLi XuanKuang HaixueWang QiuhongWang WenranZhang Shuxiang - Polycystic ovary syndrome (PCOS) affects 11%-13% of reproductive-age women worldwide and is pathologically associated with granulosa cell dysfunction. This study employed transcriptome sequencing of granulosa cells from PCOS patients and non-PCOS controls, followed by Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and Gene Set Enrichment Analysis. Key differentially expressed genes were validated by quantitative real-time PCR. Transcriptome analysis identified 157 upregulated and 71 downregulated mRNAs in PCOS granulosa cells, with enrichment in PI3K-Akt, MAPK, and TGF-beta signaling pathways. Six genes-NPTX2, FN1, CCN1, IDH1, ZCCHC17, and CREG1-were confirmed by qRT-PCR. Protein-protein interaction network analysis identified FN1 as a central hub gene. FN1 knockdown in KGN cells suppressed proliferation, induced apoptosis, and caused G1 phase arrest, accompanied by reduced Akt phosphorylation and altered expression of cyclin D1, p21, and p27. These findings suggest a potential association between FN1 and granulosa cell proliferative dysregulation in PCOS, warranting validation in primary cells and models. - Source: PubMed
Publication date: 2026/04/24
Zhou KanHan WenquanWang QijieZhang YuWang Jiao - Accurate biomarkers that reflect disease activity, severity, and molecular pathophysiology in multiple sclerosis (MS) remain an unmet diagnostic need. We compared the performance of the established biomarkers, neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP), with emerging candidates in CSF and serum. - Source: PubMed
Publication date: 2026/04/23
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