Ask about this productRelated genes to: NPTX2 antibody
- Gene:
- NPTX2 NIH gene
- Name:
- neuronal pentraxin 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-12
- Date modifiied:
- 2016-10-05
Related products to: NPTX2 antibody
Related articles to: NPTX2 antibody
- The menopausal transition is often accompanied by neuropsychiatric symptoms such as sleep disturbances, representing a modifiable window for Alzheimer's disease and related dementia (ADRD) prevention. Current preventive strategies fail to address the heterogeneity of postmenopausal cognitive trajectories, where some women exhibit rapid cognitive decline while others maintain sustained resilience over decades. This divergence suggests distinct neuroendocrine mechanisms that remain poorly understood and untargeted by current interventions. Given estrogen's fundamental role in brain function, compensatory enhancement of brain-local estrogen synthesis supports synaptic integrity and promotes resilience against neurodegeneration. Parvalbumin-positive (PV) interneurons enhance synaptic activity-dependent brain-derived estradiol (BDE2) synthesis in a sex-specific manner. Non-invasive gamma-rhythmic neuromodulation targeting PV interneurons via closed-loop protocols delivered during sleep can maximize therapeutic efficacy while minimizing off-target effects. A dual-cohort, parallel-group trial using neuronal pentraxin-2 (NPTX2) as a surrogate endpoint holds promise for assessing the efficacy of ADRD prevention and risk reduction in this high-risk population. - Source: PubMed
Zhang WenjingZheng XuexinLian TenghongWang XiaominWang YupingPeng DantaoHuang YumingLiu ShunaiZheng YunfengZhang Wei - 1. Despite the pivotal role of the hypothalamic-pituitary-gonadal (HPG) axis in avian reproduction, the underlying molecular mechanisms that govern sexual maturity and spermatogenesis in roosters are not well elucidated. This study aimed to explore gene expression changes in the HPG axis using Wenchang cockerels.2. Phenotypic results showed significant testicular growth from 18 to 20 weeks of age. Transcriptome analyses identified 2,154 differentially expressed genes (DEG) in testes, which was markedly higher than those identified in hypothalamus (52 DEG) and pituitary (27 DEG).3. Functional enrichment analysis showed neuroactive ligand-receptor interactions and hormone transport pathways in the hypothalamus and pituitary and ciliary motility and spermatogenesis pathways in the testes.4. Protein-protein interaction (PPI) networks analysis pinpointed key hub genes, such as , , , , , and , associated with spermatogenesis and sperm motility.5. This research gave insights into the genetic regulatory networks within the HPG axis that orchestrate testicular development and maturation in roosters, paving the way for potential applications in the molecular breeding of breeding roosters for reproductive optimisation. - Source: PubMed
Publication date: 2026/08/19
Liu YAzim SLi JZhang BZhang ZLuo XSu CLiu XFeng Y - To establish a doxorubicin (DOX)-resistant acute myeloid leukemia (AML) cell line and explore the mechanisms of its drug resistance. - Source: PubMed
Feng Lu-LuWang Yu-TingHuang Chao-FanSun Cong-YongJun Ya-LiZhang Li - Synaptic dysfunction is increasingly recognized as a core feature of psychiatric disorders, yet fluid biomarkers that reflect such changes in vivo are lacking. Here, we applied targeted mass spectrometry to quantify low-abundant synaptic proteins in cerebrospinal fluid from 672 individuals with anorexia nervosa, attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), schizophrenia spectrum disorders (SCZ + ), and healthy controls. Synaptic protein levels were markedly reduced in SCZ + , with intermediate reductions in BD and ADHD. Using a data-driven approach to model transdiagnostic contrasts-psychotic experience, cognitive and functional impairment-a shared two-biomarker signature emerged: elevated LAMP1, a phagolysosomal marker, and reduced NPTX2, a synaptic activity marker which inhibits complement-dependent synapse elimination. Combining this ratio with polygenic scores improved diagnostic classification. Key findings were extended to an independent cohort at first-episode psychosis. These results support synaptic pathology as a measurable and transdiagnostic feature across several psychiatric disorders and highlight the potential of integrating fluid and genetic biomarkers. - Source: PubMed
Publication date: 2026/07/30
Göteson AndreasNilsson JohannaCamporesi ElenaKlahn Anna LuisaHörbeck ElinSigström RobertJonsson LinaSparding TimeaPålsson ErikPelanis AurimantasGoulding AnneliIsgren AnniellaErhardt SophieCervenka SimonBulik Cynthia MZetterberg HenrikBlennow KajSellgren Carl MBrinkmalm AnnLandén Mikael - Major depressive disorder (MDD) has been linked to oxidative stress, mitochondrial dysfunction, and impaired neuronal plasticity, but the reproducibility of related transcriptomic alterations across postmortem brain cohorts remains uncertain. We performed a targeted cross-platform analysis of a prespecified 14-gene panel spanning antioxidant defense, mitochondrial-redox regulation, cellular stress responses, neurotrophic signaling, synaptic plasticity, and polyamine metabolism across seven postmortem dorsolateral prefrontal cortex cohorts comprising 146 MDD cases and 179 controls. Primary support required Fisher-combined evidence, Benjamini-Hochberg correction across the panel, and concordant MDD-minus-control direction across all available cohorts. , , , , and met these criteria, with lower expression in MDD. The same five-gene pattern was supported by weighted signed Stouffer analysis, one-stage generalized least-squares models, random-effects meta-analysis, and 200,000 disease-label permutations; none produced at least five genes meeting the complete primary-support criterion (empirical = 5.0 × 10). The most robust cross-cohort finding was a convergent lower-expression pattern across genes supporting redox-linked stress adaptation, polyamine homeostasis, neurotrophic signaling, activity-dependent transcription, and synaptic plasticity. This pattern suggests impaired molecular capacity for neuronal stress resilience and adaptive plasticity in MDD. - Source: PubMed
Publication date: 2026/07/22
Klepacki HubertOrdak MichalKowalczuk KrystynaHermanowicz Justyna MagdalenaWaszkiewicz Napoleon