Ask about this productRelated genes to: NPTX2 antibody
- Gene:
- NPTX2 NIH gene
- Name:
- neuronal pentraxin 2
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-12
- Date modifiied:
- 2016-10-05
Related products to: NPTX2 antibody
Related articles to: NPTX2 antibody
- To establish a doxorubicin (DOX)-resistant acute myeloid leukemia (AML) cell line and explore the mechanisms of its drug resistance. - Source: PubMed
Feng Lu-LuWang Yu-TingHuang Chao-FanSun Cong-YongJun Ya-LiZhang Li - Synaptic dysfunction is increasingly recognized as a core feature of psychiatric disorders, yet fluid biomarkers that reflect such changes in vivo are lacking. Here, we applied targeted mass spectrometry to quantify low-abundant synaptic proteins in cerebrospinal fluid from 672 individuals with anorexia nervosa, attention-deficit/hyperactivity disorder (ADHD), bipolar disorder (BD), schizophrenia spectrum disorders (SCZ + ), and healthy controls. Synaptic protein levels were markedly reduced in SCZ + , with intermediate reductions in BD and ADHD. Using a data-driven approach to model transdiagnostic contrasts-psychotic experience, cognitive and functional impairment-a shared two-biomarker signature emerged: elevated LAMP1, a phagolysosomal marker, and reduced NPTX2, a synaptic activity marker which inhibits complement-dependent synapse elimination. Combining this ratio with polygenic scores improved diagnostic classification. Key findings were extended to an independent cohort at first-episode psychosis. These results support synaptic pathology as a measurable and transdiagnostic feature across several psychiatric disorders and highlight the potential of integrating fluid and genetic biomarkers. - Source: PubMed
Publication date: 2026/07/30
Göteson AndreasNilsson JohannaCamporesi ElenaKlahn Anna LuisaHörbeck ElinSigström RobertJonsson LinaSparding TimeaPålsson ErikPelanis AurimantasGoulding AnneliIsgren AnniellaErhardt SophieCervenka SimonBulik Cynthia MZetterberg HenrikBlennow KajSellgren Carl MBrinkmalm AnnLandén Mikael - Major depressive disorder (MDD) has been linked to oxidative stress, mitochondrial dysfunction, and impaired neuronal plasticity, but the reproducibility of related transcriptomic alterations across postmortem brain cohorts remains uncertain. We performed a targeted cross-platform analysis of a prespecified 14-gene panel spanning antioxidant defense, mitochondrial-redox regulation, cellular stress responses, neurotrophic signaling, synaptic plasticity, and polyamine metabolism across seven postmortem dorsolateral prefrontal cortex cohorts comprising 146 MDD cases and 179 controls. Primary support required Fisher-combined evidence, Benjamini-Hochberg correction across the panel, and concordant MDD-minus-control direction across all available cohorts. , , , , and met these criteria, with lower expression in MDD. The same five-gene pattern was supported by weighted signed Stouffer analysis, one-stage generalized least-squares models, random-effects meta-analysis, and 200,000 disease-label permutations; none produced at least five genes meeting the complete primary-support criterion (empirical = 5.0 × 10). The most robust cross-cohort finding was a convergent lower-expression pattern across genes supporting redox-linked stress adaptation, polyamine homeostasis, neurotrophic signaling, activity-dependent transcription, and synaptic plasticity. This pattern suggests impaired molecular capacity for neuronal stress resilience and adaptive plasticity in MDD. - Source: PubMed
Publication date: 2026/07/22
Klepacki HubertOrdak MichalKowalczuk KrystynaHermanowicz Justyna MagdalenaWaszkiewicz Napoleon - Alzheimer's disease (AD) is clinicopathologically heterogeneous. A proportion of patients living with AD present clinically at a younger onset of cognitive symptoms before 65 years old and/or non-amnestic clinical syndromes. Neuropathologically, corticolimbic distribution of neurofibrillary tangle pathology occurs on a continuum with some cases having greater cortical tau pathology relative to limbic regions and others with relatively restricted accumulation in limbic structures. These patterns of corticolimbic tangle distribution are associated with clinical presentation and age at onset. This study sought to examine protein expression differences across the spectrum of clinicopathologic heterogeneity using the NULISA targeted proteomics platform. - Source: PubMed
Publication date: 2026/07/07
Dunlop Sara RoseLincoln Sarah JPeng ZhongweiGraff-Radford Neill RLachner ChristianDay Gregory STranovich Jessica FReichard R RossDickson Dennis WPetersen Ronald CBoeve Bradley FNguyen AiviGrinberg Lea TGraff-Radford JonathanAlgeciras-Schimnich AliciaMurray Melissa E - Lower levels of several synaptic proteins in cerebrospinal fluid (CSF) have been associated with greater cognitive decline among older adults, but there is limited understanding of their associations with brain structure. This study is among the first to examine the cross-sectional relationship between levels of three synaptic proteins (VGF, NPTX2, and GluA4) with magnetic resonance imaging (MRI) measures of white matter microstructure and volumes, and with cognitive performance. We also examined whether relationships between synaptic protein levels and white matter measures are influenced by CSF Alzheimer's disease (AD) biomarker levels [ratio of p-tau/(Aβ/Aβ)]. - Source: PubMed
Publication date: 2026/06/15
Paitel Elizabeth RPettigrew CorinneMoghekar AbhayMiller Michael IFaria Andreia VAlbert MarilynNa Chan HyunWorley PaulSoldan Anja