Ask about this productRelated genes to: DEPDC1 antibody
- Gene:
- DEPDC1 NIH gene
- Name:
- DEP domain containing 1
- Previous symbol:
- -
- Synonyms:
- DEP.8, FLJ20354, SDP35, DEPDC1A
- Chromosome:
- 1p31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-23
- Date modifiied:
- 2016-10-05
Related products to: DEPDC1 antibody
Related articles to: DEPDC1 antibody
- The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) still remains poor and the exact molecular mechanisms still unclear. Dysregulation of DEP domain containing 1 (DEPDC1) has been implicated in the pathogenesis of a variety of cancers. However, the role of DEPDC1 in PDAC is poorly understood. Here in this study, we identified that DEPDC1 was high-expressed in PDAC tissues compared with the adjacent normal pancreatic tissues, and its expression level was correlated with poor prognosis of PDAC. We also found that TCF7L2 up-regulated DEPDC1 expression by binding to its promoter sequence specifically. Further bioinfromatic and functional analysis demonstrated that the TCF7L2/DEPDC1 axis can promote tumor cell proliferation and invasion by upregulating glycolysis. Glycolysis reprogramming influences the activation and function of immune cells, ultimately leading to immune escape and cancer progression. In consistent with this, our results showed that the TCF7L2/DEPDC1 axis could form an immunosuppressive tumor microenvironment via promoting tumor glycolysis. Our findings revealed the critical role of TCF7L2/DEPDC1 axis in the carcinogenesis and development of PDAC, which provided a promising therapeutic strategy to improve the prognosis of PDAC patients. - Source: PubMed
Publication date: 2026/03/19
Tasiheng YesiboliKenjiabieke JiayidengTasiheng NuerzhatiAdilijiang KawushaerCheng He - Brain metastasis (BM) carries a poor prognosis, yet the molecular basis of brain tropism remains unclear. Analysis of breast cancer BM (BCBM) revealed pervasive p53 inactivation through mutations and/or aneuploidy, with pathway disruption already present in primary tumors. Functionally, p53 inactivation markedly increased BCBM formation and growth in vivo, causally linking p53 perturbation to BM. Mechanistically, p53 inactivation upregulated SCD1 and fatty acid synthesis (FAS), essential for brain-metastasizing cells; SCD1 knockout abolished the p53-dependent growth advantage. Molecularly, p53 suppressed SCD1 directly through promoter binding and indirectly by downregulating its co-activator DEPDC1. Astrocytes further enhanced FAS by secreting factors that were metabolized in a p53-dependent manner, promoting tumor survival, proliferation and migration. Finally, p53-deficient tumors were sensitive to FAS inhibition ex vivo and in vivo. Thus, we identify p53 inactivation as a driver of BCBM, reveal p53-dependent and astrocyte-dependent FAS modulation and highlight FAS as a therapeutically targetable BCBM vulnerability. - Source: PubMed
Publication date: 2025/12/29
Laue KathrinPozzi SabinaZerbib JohannaBertolio RebeccaEliezer YonatanCohen-Sharir YaelWinkler TomCaputo ManuelRicci Alessia AAdler LitalKhoury RamiLongobardi GiuseppeSlutsky RachelLeikin-Frenkel Alicia IOvadia ShaiLange KatharinaRustighi AlessandraPiazza SilvanoSacconi AndreaMagesh Rayna YKeller Faith NBerthelet JeanSchäffer AlexanderSaad RonIsraeli Dangoor SaharSzczepanowska KarolinaBarshack IrisLiao YangMalitsky SergeyBrandis AlexanderBroggini ThomasCzabanka MarcusShi WeiMerino DelphineWatson Emma VBlandino GiovanniErez AyeletAshery-Padan RuthMedyouf HindBertero LucaDel Sal GianninoSatchi-Fainaro RonitBen-David Uri - DEP domain-containing protein 1 (DEPDC1) is essential for cell cycle regulation and is increasingly associated with multiple cancers. Accumulating evidence demonstrates that DEPDC1 is significantly upregulated in tumor tissues than in non-malignant tissues across 31 cancer types. DEPDC1 overexpression has been linked to poor prognostic in many cancers, including ACC, KICH, KIRC, KIRP, LGG, LIHC, LUAD, MESO, PAAD, PCPG, SARC, UCEC, and UVM. - Source: PubMed
Publication date: 2025/10/08
Cui YiOuyang WeiweiLuo DaiqinLi YouyouTian Chuan - Endometrial carcinoma (EC) ranks among the three most prevalent malignant tumors affecting the female reproductive system. DEPDC1-AS1 is a newly identified lncRNA, and its mechanism of action in EC remains to be explored. - Source: PubMed
Publication date: 2025/09/26
Wang RenchengJi Jianhua - Microalgae, with their high photosynthetic efficiency and sustainability, hold promise to produce bioactive compounds, chemicals, cosmetics, and biofuels. This study aims to understand the molecular mechanisms of bioactive compounds from microalgae using integrative bioinformatics approaches to identify their potential therapeutic applications. - Source: PubMed
Publication date: 2025/07/24
Shahid HinaIbrahim MuhammadAlonazi Wadi BChi Zhanyou