Ask about this productRelated genes to: RGL3 antibody
- Gene:
- RGL3 NIH gene
- Name:
- ral guanine nucleotide dissociation stimulator like 3
- Previous symbol:
- -
- Synonyms:
- FLJ32585
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-03-11
- Date modifiied:
- 2018-11-19
Related products to: RGL3 antibody
Related articles to: RGL3 antibody
- Stone cells originate from secondary cell wall thickening and contain abundant lignin. Their excessive accumulation compromises pear fruit quality, yet the endogenous hormonal mechanisms governing stone cell formation remain unclear. Here, co-expression network analysis using transcriptome data - the flesh of 206 sand pear accessions sampled at the critical stage of stone cell formation and multitissues of 'Dangshansuli' - showed that auxin biosynthetic gene YUCCA6 and auxin signaling activator ARF6 were strongly co-expressed with lignin-related genes. A positive correlation was observed between endogenous indole-3-butyric acid (IBA) levels and the rate of stone cell accumulation. Moreover, both YUCCA6 overexpression and exogenous IBA treatment enhanced lignin deposition in pear, demonstrating that auxin promoted stone cell lignification. Additionally, ARF6 promoted stone cell lignification. Mechanistic analyses revealed that ARF6 activated HB49, which subsequently upregulated MYB169, a key transcriptional activator of lignin biosynthesis, thereby promoting stone cell lignification. Notably, ARF6 interacted with repressors IAA27 or RGL3, which suppressed HB49 activation; this repression was alleviated by auxin or gibberellin treatment, which restored ARF6-mediated activation of HB49. These results establish ARF6 as an integrator of auxin and gibberellin signaling pathways and provide new mechanistic insights into auxin-gibberellin crosstalk in regulating stone cell lignification. - Source: PubMed
Publication date: 2026/04/27
Shan YanfeiChen ShulinCai JianfaZhou ZhengPan ChongLiu JiahaoZheng PengfeiLi ChengLiu YueyuanXue ChengWu Jun - Understanding the development of midbrain dopaminergic (mesDA) neurons is essential for advancing cell replacement therapies for Parkinson's disease. In the developing ventral midbrain (VM), radial glia (Rgl) cells are the progenitors of mesDA neurons. However, distinct Rgl subtypes have recently been identified, and their individual roles are unclear. Here we analyze transcriptomic data from mouse and human VM Rgl to define their contributions to mesDA neuron development. We identify Rgl1 as the progenitor of the mesDA lineage, and reveal a Rgl1 transcriptional network coordinated by BMAL1, which we validate as a new regulator of mesDA neurogenesis. Moreover, we uncover Rgl3 as a key signaling subtype and show that factors expressed by Rgl3 promote the survival and yield of human stem cell-derived mesDA neurons. Our findings delineate distinct roles of Rgl subtypes, elucidate lineage relationships in the developing VM and uncover new factors that improve the derivation of clinically relevant human mesDA neurons. - Source: PubMed
Publication date: 2026/02/16
Ásgrímsdóttir Emilía SifBassini Luca FusarSun TingPuigsasllosas Pastor Clàudiadi Val Cervo Pia RivettiGyllborg DanielLee KawaiGrigsby Christopher LJude BaptisteAbaurre CarmenIslam SaifulLönnerberg PeterVillaescusa CarlosSaltó CarmenBarker Roger ALinnarsson StenCastelo-Branco GoncaloLa Manno GioeleToledo Enrique MArenas Ernest - Hypertension is influenced by both genetic and dietary factors. Understanding gene-diet interactions across populations is key to precision prevention. - Source: PubMed
Publication date: 2026/01/08
Hur Haeng JeonYang Hye JeongKim Min JungJang Hyun-JunKim Myung-SunnyPark Sunmin - Stone cells are a remarkable trait of pear (Pyrus spp.) fruit, with their abundance directly affecting fruit quality and varying significantly among cultivars. While plant hormones influence fruit development, their role in stone cell formation remains poorly understood. Here, we conducted a co-expression network analysis using RNA-seq data from 206 pear (Pyrus pyrifolia), linking hormone biosynthesis genes with known regulators of stone cell formation. This analysis identified that gibberellin (GA) 2-oxidase 1-1 (GA2ox1-1), a GA oxidase gene whose expression correlates significantly with stone cell content across cultivars, increases during key developmental stages, and localizes specifically to stone cells, as revealed by RNA in situ hybridization. Functional validation showed that expression of GA2ox1-1 in pear fruit, callus, and Arabidopsis (Arabidopsis thaliana) resulted in significantly lower lignin content and markedly lower active GA levels. To elucidate the GA-mediated regulation of stone cell lignification, we identified the DELLA protein REPRESSOR of ga1-3 Like 3 (RGL3), a key component of the GA signaling pathway. RGL3 interacts with myeloblastosis transcription factor MYB169, a known positive regulator of lignin biosynthesis, and suppresses MYB169-mediated activation of lignin biosynthesis genes, thereby negatively regulating lignin biosynthesis. However, in the presence of GA, RGL3 inhibition was relieved, leading to MYB169 activation, upregulation of lignin biosynthesis genes, and enhanced lignin deposition. These findings clarify the role of GA in stone cell formation and reveal a regulatory mechanism involving the RGL3-MYB169 module. This work provides insights into modulating stone cell content to improve pear fruit quality. - Source: PubMed
Zheng PengfeiCai JianfaXue YongsongZhang XiangWang ZikangXu ShaozhuoPan ChongWang RunzeXue ChengWu Jun - This study analyzed somatic mutations and differentially expressed genes in primary oral squamous cell carcinoma (OSCC) tumors to identify prognostic markers for radiotherapy (RT) and concurrent chemo-radiation therapy (CCRT). We used longitudinal whole-exome sequencing (WES) data from a patient who developed radiation-induced sarcoma (RIS) after CCRT with public datasets (TCGA and GSE41613) to identify genes associated with 24-month overall survival (OS). Candidates were further refined using Cox regression for OS. Twenty-two prognostic genes were identified and validated in WES data, functioning as indicators of RT and CCRT resistance. In patients with poor outcomes within 24 months post-RT, CLTCL1, RGL3 and H3C12 showed significant prognostic value in multivariate Cox analyses, while SLC35G5, GARS1 and JPH3 were identified as prognostic markers for CCRT. Limited overlap was observed between RT and CCRT, with TJP3 being the only common gene. RNA-seq data from the GSE217645 revealed that TJP3 exhibited significantly altered expression between radiosensitive and radioresistant cell lines (p = 0.037). RT-related genes were predominantly found in primary tumors, whereas CCRT-related genes were distributed across primary tumor, inflamed granulation tissue, inflammatory myofibroblastic proliferation and RIS. These findings provide insights into molecular mechanisms underlying RT and CCRT resistance, supporting future directions in precision medicine. - Source: PubMed
Publication date: 2025/08/21
Kuk Su KyungLee Jae IlLee Jong-HoKwon Ik-JaePang Kang Mi