Ask about this productRelated genes to: Ercc1 antibody
- Gene:
- ERCC1 NIH gene
- Name:
- ERCC excision repair 1, endonuclease non-catalytic subunit
- Previous symbol:
- -
- Synonyms:
- RAD10
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-05-23
Related products to: Ercc1 antibody
Related articles to: Ercc1 antibody
- Pharmacogenomic (PGx) variation is an important determinant of inter-individual variability in drug response. While germline pharmacogenomics has been extensively studied, somatic alterations affecting these pharmacogenes in tumors remain less systematically characterised. - Source: PubMed
Publication date: 2026/07/22
AlMulla AishaKaur SimerpreetBalyan PrachiAl-Saafin SanaBalyan Manoj KumarVelayutham DineshJithesh Puthen Veettil - Microsatellite instability-high (MSI-H) colorectal cancer cells depend on the Werner syndrome helicase (WRN) to resolve cruciform DNA structures that arise from expanded TA-dinucleotide repeats. Loss of WRN induces replication stress and double-strand breaks (DSBs), a vulnerability that can be recapitulated by the selective WRN inhibitor HRO761 in MSI cancer cells. To uncover the mechanisms governing sensitivity to WRN inhibition, we conducted genome-wide CRISPR/Cas9 screens in colorectal cancer cell lines treated with or without HRO761. These screens identified SMARCAL1 as a key modulator of WRN dependency. Depletion of SMARCAL1 rendered cells resistant to WRN inhibition, and rescue of this effect required the ATPase/translocase activity of SMARCAL1. Mechanistically, SMARCAL1 antagonized WRN and supported cruciform DNA structures, thereby enhancing cellular reliance on WRN. In addition, the MRE11-RAD50-NBS1 (MRN) complex, rather than MUS81 or ERCC1/XPF, was the principal mediator of cruciform DNA processing following WRN inhibition. Acute disruption of the MRN complex conferred profound resistance to WRN inhibition, whereas ATM deficiency produced a more modest resistant phenotype. Further genetic and pharmacological epistasis analyses demonstrated that the MRN complex regulates WRN inhibitor sensitivity through both ATM-dependent signaling and MRE11 nuclease-dependent functions. Importantly, the key resistance mechanisms identified in this study were independently validated using a structurally distinct clinical-stage WRN inhibitor VVD-214. Collectively, these findings identify the SMARCAL1-MRN-ATM axis as a critical regulator of WRN dependency and provide mechanistic insight into resistance to WRN-targeted therapy. - Source: PubMed
Publication date: 2026/07/22
Ma TiantianWu JiboLi SitingChen Junjie - Endometriosis is a chronic, estrogen-dependent inflammatory disorder characterized by the ectopic implantation of endometrial-like tissue. Although retrograde menstruation is highly prevalent, only a subset of women develops the disease. This epidemiologic paradox suggests that intrinsic molecular alterations in the eutopic endometrium may precondition refluxed cells to survive under inflammatory and oxidative stress. - Source: PubMed
Publication date: 2026/07/21
Wang JuanLi WangshuFeng JiuxiangWang Zhongmin - This study aimed to evaluate the association between pretreatment immunohistochemical expression of hypoxia-inducible factor 1 alpha (HIF-1α) and excision repair cross-complementation group 1 (ERCC1) and clinical outcomes in patients with locally advanced cervical cancer (LACC) treated with definitive concurrent radiochemotherapy (cRCT). - Source: PubMed
Publication date: 2026/07/15
Sert FatmaSerin GurdenizAlanyali SenemOzturk MeltemDelikaya MertZekioglu OsmanOzsaran Zeynep - Understanding age-related changes in migraine is pivotal, considering the increasing global life expectancy. In addition, both aging and migraine are prominent cardiovascular risk factors. It remains unclear whether calcitonin gene-related peptide (CGRP) release changes with age across trigeminovascular components, and how this relates to peripheral responses to migraine-related vasodilatory molecules. The primary aim was to investigate age-related effects on CGRP release from the trigeminovascular system by studying a mouse model of combined accelerated neuronal and vascular aging, the DNA repair-deficient Ercc1 mice. Second, we assessed the effects of aging on isolated coronary vasodilatory responses to CGRP and forskolin. - Source: PubMed
Publication date: 2026/07/03
Al-Hassany LindaRubio-Beltrán EloisaLabastida-Ramirez AlejandroGarrelds Ingrid MDanser A H JanRoks Anton J MMaassenVanDenBrink Antoinette