Ask about this productRelated genes to: Ercc1 antibody
- Gene:
- ERCC1 NIH gene
- Name:
- ERCC excision repair 1, endonuclease non-catalytic subunit
- Previous symbol:
- -
- Synonyms:
- RAD10
- Chromosome:
- 19q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2016-05-23
Related products to: Ercc1 antibody
Related articles to: Ercc1 antibody
- Growing evidence implicates the accelerated cellular aging in the lung is a pivotal contributor in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD). Notably, the specific role of senescent pulmonary microvascular endothelial cells (PMECs) and the development of therapies targeting them remain poorly defined. Tongxinluo (TXL), a patent traditional Chinese medicine with "Yiqi Huoxue Tongluo" effects, shows therapeutic promise in COPD, potentially by mitigating PMEC injury. However, the precise molecular mechanisms and key bioactive constituents underlying TXL's action are incompletely elucidated. - Source: PubMed
Publication date: 2026/08/05
Xiong MingyuHe ZhuoGuo JingShi MinShi JingjingHou BingYuan CaiyunHan NingxingSun JiemengWang LeHou YunlongQi HuiJia Zhenhua - Pharmacogenomic (PGx) variation is an important determinant of inter-individual variability in drug response. While germline pharmacogenomics has been extensively studied, somatic alterations affecting these pharmacogenes in tumors remain less systematically characterised. - Source: PubMed
Publication date: 2026/07/22
AlMulla AishaKaur SimerpreetBalyan PrachiAl-Saafin SanaBalyan Manoj KumarVelayutham DineshJithesh Puthen Veettil - Microsatellite instability-high (MSI-H) colorectal cancer cells depend on the Werner syndrome helicase (WRN) to resolve cruciform DNA structures that arise from expanded TA-dinucleotide repeats. Loss of WRN induces replication stress and double-strand breaks (DSBs), a vulnerability that can be recapitulated by the selective WRN inhibitor HRO761 in MSI cancer cells. To uncover the mechanisms governing sensitivity to WRN inhibition, we conducted genome-wide CRISPR/Cas9 screens in colorectal cancer cell lines treated with or without HRO761. These screens identified SMARCAL1 as a key modulator of WRN dependency. Depletion of SMARCAL1 rendered cells resistant to WRN inhibition, and rescue of this effect required the ATPase/translocase activity of SMARCAL1. Mechanistically, SMARCAL1 antagonized WRN and supported cruciform DNA structures, thereby enhancing cellular reliance on WRN. In addition, the MRE11-RAD50-NBS1 (MRN) complex, rather than MUS81 or ERCC1/XPF, was the principal mediator of cruciform DNA processing following WRN inhibition. Acute disruption of the MRN complex conferred profound resistance to WRN inhibition, whereas ATM deficiency produced a more modest resistant phenotype. Further genetic and pharmacological epistasis analyses demonstrated that the MRN complex regulates WRN inhibitor sensitivity through both ATM-dependent signaling and MRE11 nuclease-dependent functions. Importantly, the key resistance mechanisms identified in this study were independently validated using a structurally distinct clinical-stage WRN inhibitor VVD-214. Collectively, these findings identify the SMARCAL1-MRN-ATM axis as a critical regulator of WRN dependency and provide mechanistic insight into resistance to WRN-targeted therapy. - Source: PubMed
Publication date: 2026/07/22
Ma TiantianWu JiboLi SitingChen Junjie - Endometriosis is a chronic, estrogen-dependent inflammatory disorder characterized by the ectopic implantation of endometrial-like tissue. Although retrograde menstruation is highly prevalent, only a subset of women develops the disease. This epidemiologic paradox suggests that intrinsic molecular alterations in the eutopic endometrium may precondition refluxed cells to survive under inflammatory and oxidative stress. - Source: PubMed
Publication date: 2026/07/21
Wang JuanLi WangshuFeng JiuxiangWang Zhongmin - This study aimed to evaluate the association between pretreatment immunohistochemical expression of hypoxia-inducible factor 1 alpha (HIF-1α) and excision repair cross-complementation group 1 (ERCC1) and clinical outcomes in patients with locally advanced cervical cancer (LACC) treated with definitive concurrent radiochemotherapy (cRCT). - Source: PubMed
Publication date: 2026/07/15
Sert FatmaSerin GurdenizAlanyali SenemOzturk MeltemDelikaya MertZekioglu OsmanOzsaran Zeynep