Ask about this productRelated genes to: FAM79B antibody
- Gene:
- TPRG1 NIH gene
- Name:
- tumor protein p63 regulated 1
- Previous symbol:
- FAM79B
- Synonyms:
- FLJ41238, FLJ43694
- Chromosome:
- 3q28
- Locus Type:
- gene with protein product
- Date approved:
- 2005-07-21
- Date modifiied:
- 2014-11-19
Related products to: FAM79B antibody
Related articles to: FAM79B antibody
- Laryngeal dysplasia and Reinke's edema (RE) are common vocal fold lesions associated with smoking. While the former is cancer prone, most cases of the latter do not undergo malignant transformation. Therefore, we proposed identifying biomarkers of smoking-induced benign-malignant transformation of vocal fold lesions. - Source: PubMed
Publication date: 2025/05/19
Liu Yun-YiZhuang Pei-Yun - Glioma represents the most prevalent intracranial neoplasms. Lower-grade gliomas (LGGs) are an important subtype of glioma, but the risk stratification of LGG has not been fully elucidated. As a recently recognized form of programmed cell death, cuproptosis is intimately tied to mitochondrial metabolism. Moreover, investigations have revealed that cuproptosis has been implicated in tumor initiation and progression. Long noncoding RNAs (lncRNAs) are engaged in diverse biological processes and connected with the malignant phenotype of gliomas. However, the significance of cuproptosis-related lncRNAs (CRLs) in LGG development remains not fully elucidated. In this work, 963 CRLs were identified using correlation analysis, and a prognostic signature was constructed based on LASSO and multivariate Cox regression analyses. This signature comprised four CRLs: , tumor protein p63 regulated 1-antisense RNA 1 (), , and LYR motif containing 4-antisense RNA 1 (). According to the CRL-based signature, LGG patients were classified into distinct risk groups. To investigate the involvement of biological processes in each LGG sample, we performed gene set variation analysis (GSVA) and gene set enrichment analysis (GSEA) comparing the different risk stratifications. Subsequently, the Estimation of STromal and Immune cells in MAlignant Tumor tissues using Expression (ESTIMATE) data and the tumor immune dysfunction and exclusion (TIDE) were utilized to access the tumor immune landscape of LGG samples. The results demonstrated that the immune landscapes of different risk stratifications differed significantly. Furthermore, we explored the association between the CRL risk signature and immunotherapy effectiveness using the IMvigor210 dataset. Several prospective drugs targeting samples with high scores were predicted, namely, MG-132, PLX-4720, AZD6482, and BMS-536924. We verified the antiglioma effect of MG-132 in vitro. Moreover, experiments conducted in vitro demonstrated that knockdown of the expression of the CRLs and might impair the migration and proliferation capacity of glioma cells. Taken together, these results indicate that CRLs are linked to prognosis and immune characteristics in LGG and give innovative therapeutic methods for individuals with LGG across different risk stratifications. - Source: PubMed
Publication date: 2025/12/08
Wang MengyangYang JianmeiShen LeiYang JingyiLuo MingDuan Faliang - Our aim was to evaluate the regulation of messenger RNAs (mRNAs) and biological pathways by long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in ischemic stroke. We employed weighted gene co-expression network analysis (WGCNA) to construct two co-expression networks for mRNAs with circRNAs and lncRNAs, respectively, to investigate their association with ischemic stroke. We compared the overlap of mRNAs and biological pathways in the stroke-associated modules of the two networks. Furthermore, we validated the association of key non-coding RNAs with the risk of ischemic stroke and poor prognosis using quantitative real-time polymerase chain reaction. Ischemic stroke patients exhibited lower eigengene expression in the turquoise module associated with lncRNAs and mRNAs, as well as in the turquoise, red, and greenyellow modules associated with circRNAs and mRNAs in ischemic stroke. In the lncRNA-mRNA network and circRNA-mRNA network, we observed a significant overlap of the 5126 mRNAs (P < 0.001) and 51 biological pathways (P < 0.001), respectively. Among the ten key non-coding RNAs, lnc-TPRG1-AS1, lnc-GUK1, and hsa_circ_RELL1 were significantly increased (P < 0.05), while hsa_circ_ZBTB20 and hsa_circ_ERBB2 were significantly decreased (P < 0.05) in ischemic stroke. Additionally, ischemic stroke patients with poor functional outcome had significantly lower levels of hsa_circ_ZBTB20 and hsa_circ_ERBB2 compared to those with favorable prognosis (P < 0.05). Our findings suggest lncRNAs and circRNAs display similar biological functions in ischemic stroke. Key non-coding RNAs may be associated with the risk and clinical prognosis of ischemic stroke. These results warrant further validation in the future studies. - Source: PubMed
Publication date: 2025/01/27
Xu TianTao MingfengLin YizhouZhang JiayuanWang ZiyiLi YongxinLi LingliAn Jinlu - Cervical squamous cell carcinoma (CSCC) has a poor prognosis due to persistent HPV infection. LncRNA TPRG1-AS1 is linked to regulating the development of many cancers, so the regulatory mechanism and prognostic value of TPRG1-AS1 in CSCC were explored. - Source: PubMed
Publication date: 2024/12/18
Fan YangYe LanWang ShuyuWang JunweiWang KeLi Ying - Triglyceride (TG)/HDL-C ratio (THR) is a surrogate predictor of hyperinsulinemia. To identify novel genetic loci for THR change over time (ΔTHR), we conducted genome-wide association study (GWAS) and genome-wide linkage scan (GWLS) among nondiabetic Europeans from the Long Life Family Study (n = 1,384). Subjects with diabetes or on dyslipidemia medications were excluded. ΔTHR was derived using growth curve modeling and adjusted for age, sex, field centers, and principal components. GWAS used a linear mixed model accounting for familial relatedness. GWLS employed haplotype-based identity-by-descent estimation with 0.5 cM average spacing. Heritability of ΔTHR was moderate (46%). Our GWAS identified a significant locus at the LPL (P = 1.58e-9) for ΔTHR; this locus has been reported before influencing baseline THR levels. Our GWLS found significant linkage with a logarithm of the odds exceeding 3 on 3q28 (logarithm of the odds = 4.1). Using a subset of 25 linkage-enriched families, we assessed sequence elements under 3q28 and identified two novel variants (EIF4A2 [eukaryotic translation initiation factor 4A2]/ADIPOQ-rs114108468, p = 5e-6, minor allele frequency = 1.8%; TPRG1-rs16864075, p = 3e-6, minor allele frequency = 8%; accounted for ∼28% and ∼29% of the linkage, respectively). While the former variant was associated with EIF4A2 (p = 7e-5)/ADIPOQ (P = 3.49e-2) transcriptional levels, the latter variant was not associated with TPRG1 (P = 0.23) transcriptional levels. Replication in the Framingham Heart Study Offspring Cohort observed modest effect of these loci on ΔTHR. Our approach discovered two novel gene variants EIF4A2/ADIPOQ-rs114108468 and TPRG1-rs16864075 on 3q28 for ΔTHR among subjects without diabetes. Our findings provided novel insights into the molecular regulation of insulin resistance. - Source: PubMed
Publication date: 2024/11/16
Wang LihuaWang SiyuAnema Jason AMoghaddam Vaha ALu YanliLin ShiowDaw E WarwickKuipers Allison LMiljkovic IvaBrent MichaelPatti Gary JThygarajan BharatZmuda Joseph MProvince Michael AAn Ping