Ask about this productRelated genes to: SERINC2 antibody
- Gene:
- SERINC2 NIH gene
- Name:
- serine incorporator 2
- Previous symbol:
- TDE2L
- Synonyms:
- FKSG84, PRO0899, TDE2
- Chromosome:
- 1p35.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-23
- Date modifiied:
- 2016-10-05
Related products to: SERINC2 antibody
Related articles to: SERINC2 antibody
- Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis; however, its patency is limited, particularly in patients with diabetes mellitus (DM). This study aimed to obtain exploratory data on whether changes in the venous transcriptome are present at the time of AVF creation in patients with DM and whether these changes are related to the graft prognosis. - Source: PubMed
Publication date: 2026/08/06
Shirouzu TomohiroKoga Jun-IchiroKatafuchi EisukeNagai YoichiroSuga RyotaSanada KenyaUeno HiromichiNakazono KazutoshiHasegawa EmiMiyamoto TetsuNakayama ToshiyukiKataoka Masaharu - Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer; however, indeterminate cytology in fine-needle aspiration biopsy (FNAB) and the limited sensitivity of single-mutation-based biomarkers remain important clinical challenges. This study aimed to identify a robust multi-gene expression signature for diagnostic evaluation and exploratory prognostic assessment of PTC. An integrative bioinformatics framework was applied to TCGA-THCA RNA-sequencing data (505 tumors and 59 normal samples). Differentially expressed genes were subjected to LASSO regression to construct a diagnostic model, which was externally validated in two independent GEO cohorts (GSE33630 and GSE60542). A seven-gene signature consisting of four upregulated genes (GABRB2, SERINC2, PTCHD4, HAPLN1) and three downregulated genes (SLC6A15, UGT2B11, GRIA1) demonstrated excellent diagnostic performance in the discovery cohort (AUC = 0.995) and remained highly accurate in external validation datasets (AUC = 0.940 and 0.938). Kaplan-Meier analysis showed significant stratification for disease-free interval (p = 0.034), although this association did not remain independent in multivariable analysis. Exploratory analyses suggested potential epigenetic regulation of several genes and distinct patterns in immune microenvironments between risk groups. Overall, these findings reveal a robust seven-gene expression signature with strong diagnostic capacity and potential prognostic relevance in PTC, highlighting its value for molecular characterization. However, further biological validation and prospective evaluation in clinically relevant cohorts are required before translational applicability can be established. - Source: PubMed
Publication date: 2026/06/21
Hukkamlı BernaDagdelen BurakSönmez Aydın Feyza - Serine incorporator (SERINC) is a family of transmembrane protein involved in lipid synthesis. Among its family members, SERINC2 has been implicated in tumor pathogenesis. Pancreatic carcinoma (PAAD), a highly malignant tumor characterized by an extremely poor prognosis, lacks effective biomarkers. To date, the association between SERINC2 and pan-cancer or tumor immunity remains unreported in the literature. Consequently, investigating the utility of SERINC2 for prognostic prediction in PAAD lays the groundwork for developing diagnostic biomarkers and SERINC2-targeted immunotherapy strategies. In this study, we used the transcriptional data in normal and tumor tissues from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) and Human Protein Atlas (HPA). Analysis of publicly available data (TCGA, GTEx, HPA) revealed significant overexpression in multiple cancers, which was associated with advanced clinicopathological stage (<0.05). Analysis of the Genomic Stability Associated Cancer Analysis (GSCA) database revealed a significant positive correlation between copy number variation (CNV) and expression levels. Conversely, DNA methylation was inversely correlated with expression (<0.05). Further investigation utilizing TCGA database demonstrated that expression was significantly associated with the expression of immune checkpoint molecules, response to immunotherapy, and the extent of immune cell infiltration. Notably, a negative correlation was observed between expression and the tumor microenvironment (TME) score in most cancer types analyzed (<0.05). We constructed a prognostic model for PAAD based on 25 differentially expressed genes (DEGs) identified from the TCGA cohort using the "limma" package. This model effectively stratified patients into high- and low-risk groups with significantly distinct survival outcomes. Immunohistochemical (IHC) analysis of 54 PAAD patient samples validated that high expression was significantly associated with poorer prognosis; patients with high expression had a significantly shorter median overall survival (19.67 50.52 months, =0.029). Collectively, our findings provide a rationale for developing SERINC2-based diagnostic biomarkers and immunotherapeutic strategies. - Source: PubMed
Zhao MinYing Hui-QiYang Yi-LeiChen Qing-LvLin WenCai Zhen-ZhaiLin Li-MiaoTeng Yang-Yang - Doxorubicin (DOX) is a highly effective anthracycline chemotherapy drug that is commonly used in clinical practice. Because of the accumulation of its drug concentration, their clinical use is associated with severe cardiotoxicity. Serine incorporator 2 (Serinc2) had been shown to play an important role in maintaining cell structure and function. Here, the main purpose of this study was to explore the effect of Serinc2 on doxorubicin-induced cardiotoxicity and its mechanism. - Source: PubMed
Publication date: 2026/01/22
Hu ShanYang ManqiLiu TaoHuang MinJu HaoLiu ZheyuKashkooli SaeedCheng MianWu Gang - Early cancer diagnosis is essential for improving prognosis and guiding treatment. However, the high dimensionality and complexity of omics data present major challenges. Computational approaches that extract stable biomarkers and enable reliable classification across cancer types and stages are needed. - Source: PubMed
Publication date: 2025/12/17
Ghaleb Moshira SAl-Berry Maryam NEbied Hala MTolba Mohamed F