Ask about this productRelated genes to: SERINC2 antibody
- Gene:
- SERINC2 NIH gene
- Name:
- serine incorporator 2
- Previous symbol:
- TDE2L
- Synonyms:
- FKSG84, PRO0899, TDE2
- Chromosome:
- 1p35.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-10-23
- Date modifiied:
- 2016-10-05
Related products to: SERINC2 antibody
Related articles to: SERINC2 antibody
- Bipolar disorder (BD) shows strong heritability and distinct symptomatic subtypes. However, the molecular basis underlying subtype-specific features remains poorly understood. Here, we identified Serinc2, a BD susceptibility gene encoding a L-serine transporter that regulates membrane lipid synthesis, as a regulator of mood-related behavioral phenotypes. Using patient plasma samples, BD iPSC-derived forebrain organoids, and Serinc2 knockout/overexpression mouse models, we found that Serinc2 expression was increased in bipolar I (BDI) but decreased in bipolar II (BDII); bi-directional manipulation of Serinc2 induced opposite changes in synaptic transmission and depression-related behaviors, accomplied by alterations in PS/SM-dependent redistribution of NMDAR subunits in postsynaptic membranes. Mechanistically, we found that thioredoxin (Txn) bound to the Serinc2 regulatory region and negatively regulate its transcription, and that differential chromatin accessibility of Txn contributed to subtype-associated expression patterns. Together, our results demonstrated a Txn-Serinc2-lipid signaling axis that linked membrane lipid composition to synaptic function and mood-related behaviors, and indicated a potential molecular framework contributing to subtype-specific features of BD. - Source: PubMed
Publication date: 2026/09/22
Fu Chong-LeiWang Ying-HanZhang Ya-NiLiu Hong-ZuoLu Si-YaoShe Xin-YuLi DanDong Bo-ChengJiang XiYuan Zhen-LiangGeng Li-LoYang Yi-MingYang Ke-BingYao Jun - Colorectal cancer (CRC) comprises heterogeneous malignant epithelial states, but it remains unclear which transcriptional programs recur across patients and how these programs relate to the immune context. - Source: PubMed
Publication date: 2026/09/03
Ying WeiZhang YuhanWu ShirongWu RuiLi Xiaoxia - Cell protrusions (CPs) promote metastasis by coordinating cell invasion, matrix remodeling, and communication with the microenvironment. The receptor tyrosine kinase AXL, activated in brain-tropic metastatic cancers, frequently localizes to CPs. The metabolic cues regulating CP biogenesis and AXL activation remain unclear. Here, we report that in invading cancer cells, phosphatidylserine is the most enriched lipid class in CPs. Mechanistically, we demonstrate that the scramblase-like transmembrane protein SERINC2 functions as a scaffold that interacts with integrins and recruits OSBPL8, an ER-plasma-membrane phosphatidylserine transporter, to CPs. This recruitment leads to phosphatidylserine accumulation and externalization at CPs, activation of CP-localized AXL, and upregulation of cell invasion. Furthermore, extracellular vesicles enriched in phosphatidylserine in a SERINC2-dependent manner stimulate autocrine AXL activation and drive M2-like microglia polarization. Accordingly, SERINC2 enhances orthotopic brain tumor growth and microglial reprogramming in vivo. Our data reveal a SERINC2-OSBPL8 axis orchestrating spatial lipid remodeling, AXL activation, and tumor-microenvironment communication. - Source: PubMed
Publication date: 2026/09/10
Yan ZhiboBeus MajaHan ZhannanPan LihongWang YihuiLu JunqiWeidenhammer Loren BLiu LiangRosario SpencerLee JingyunFurdui Cristina MLo Hui-WenKandel Eugene SSoderblom Erik JMa WeiliChen QingKotenko Sergei VBirge Raymond BNikiforov Mikhail A - Arteriovenous fistula (AVF) is the preferred vascular access for hemodialysis; however, its patency is limited, particularly in patients with diabetes mellitus (DM). This study aimed to obtain exploratory data on whether changes in the venous transcriptome are present at the time of AVF creation in patients with DM and whether these changes are related to the graft prognosis. - Source: PubMed
Publication date: 2026/08/06
Shirouzu TomohiroKoga Jun-IchiroKatafuchi EisukeNagai YoichiroSuga RyotaSanada KenyaUeno HiromichiNakazono KazutoshiHasegawa EmiMiyamoto TetsuNakayama ToshiyukiKataoka Masaharu - Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid cancer; however, indeterminate cytology in fine-needle aspiration biopsy (FNAB) and the limited sensitivity of single-mutation-based biomarkers remain important clinical challenges. This study aimed to identify a robust multi-gene expression signature for diagnostic evaluation and exploratory prognostic assessment of PTC. An integrative bioinformatics framework was applied to TCGA-THCA RNA-sequencing data (505 tumors and 59 normal samples). Differentially expressed genes were subjected to LASSO regression to construct a diagnostic model, which was externally validated in two independent GEO cohorts (GSE33630 and GSE60542). A seven-gene signature consisting of four upregulated genes (GABRB2, SERINC2, PTCHD4, HAPLN1) and three downregulated genes (SLC6A15, UGT2B11, GRIA1) demonstrated excellent diagnostic performance in the discovery cohort (AUC = 0.995) and remained highly accurate in external validation datasets (AUC = 0.940 and 0.938). Kaplan-Meier analysis showed significant stratification for disease-free interval (p = 0.034), although this association did not remain independent in multivariable analysis. Exploratory analyses suggested potential epigenetic regulation of several genes and distinct patterns in immune microenvironments between risk groups. Overall, these findings reveal a robust seven-gene expression signature with strong diagnostic capacity and potential prognostic relevance in PTC, highlighting its value for molecular characterization. However, further biological validation and prospective evaluation in clinically relevant cohorts are required before translational applicability can be established. - Source: PubMed
Publication date: 2026/06/21
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