Ask about this productRelated genes to: Med19 antibody
- Gene:
- MED19 NIH gene
- Name:
- mediator complex subunit 19
- Previous symbol:
- -
- Synonyms:
- LCMR1
- Chromosome:
- 11q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-09
- Date modifiied:
- 2014-11-19
Related products to: Med19 antibody
Related articles to: Med19 antibody
- The Wnt signaling pathway antagonist SFRP1 is frequently silenced by promoter DNA hypermethylation in colorectal cancer (CRC). MBD2, a DNA methylation reader, is known to contribute to SFRP1 epigenetic silencing. Previous work showed that MBD2 critically suppresses SFRP1 expression without altering promoter methylation, though the underlying mechanism remained unclear. Elucidating how DNA methylation silences tumor suppressor genes, such as , could reveal novel therapeutic targets with significant clinical potential. - Source: PubMed
Publication date: 2026/05/05
Huang XiujiLuo TingtingKe LinglingGuan ShaotingWu HuixianLi BoLiu YutingQi Jian - The Mediator complex bridges transcription factors and RNA polymerase II to regulate gene expression during plant immune responses. We previously demonstrated that the Mediator subunit MED19a modulates () expression through interactions with Fibrillarin 2 (FIB2) and the long non-coding RNA ELENA1 upon elf18 treatment. Because TGA transcription factors are known to play important roles in regulating genes, we sought to determine whether specific TGAs cooperate with MED19a. To identify TGA transcription factors cooperating with MED19a, we performed yeast two-hybrid assays and found that MED19a interacts with TGA1 and TGA5. These interactions were confirmed by in vitro pull-down assays and bimolecular fluorescence complementation in planta. Expression analysis revealed that , , , and were significantly upregulated in and mutants, while expression remained unchanged in TGA1 and TGA5 overexpression lines after elf18 treatment. Consistent with prior observations, expression was slightly reduced in mutants. We generated double mutants using RNAi and verified reduced expression. In triple mutants ( and ), expression levels were intermediate between those of the respective single mutants and the double mutant. These results suggest that MED19a modulates expression through physical and functional interactions with TGA1 and TGA5, contributing to fine-tuned transcriptional control of immune responses triggered by elf18 in Arabidopsis. - Source: PubMed
Publication date: 2026/03/22
Um TaeyoungLee Gang-SeobSeo Jun Sung - The Mediator complex is a central regulator of eukaryotic transcription, functioning as a dynamic molecular interface between gene-specific transcription factors and RNA polymerase II (Pol II). Although its overall architecture and general role in transcription have been extensively reviewed, accumulating genetic, genomic, and clinical evidence indicates that individual Mediator subunits make distinct and non-redundant contributions to human physiology and disease. In this review, we move beyond a generic description of Mediator function and present a subunit-resolved synthesis of Mediator biology with an emphasis on disease pathogenesis. A key feature of this review is a comprehensive table integrating disease associations and molecular functions of individual human Mediator subunits, enabling rapid assessment of functional specialization across the complex. We further discuss chromatin-based mechanisms of Mediator action, including cooperation with cohesin and architectural factors to regulate enhancer-promoter communication and higher-order genome organization. By organizing recent structural, mechanistic, and pathological findings into a unified framework, this review highlights how disruption of specific Mediator subunits contributes to cancer, developmental disorders, and metabolic disease, and outlines emerging opportunities for therapeutic intervention. - Source: PubMed
Publication date: 2026/02/26
Iyer SailakshmiIto TakashiNakagawa TakeyaHattori Naoko - The Mediator complex is a transcriptional co-factor for RNA polymerase II (Pol II)-dependent gene expression, with MED19 serving as an integral subunit. While MED19 overexpression has been documented in diverse cancer types to promote tumor progression, the underlying molecular mechanisms remain poorly understood. Here, we uncover a previously unrecognized function whereby MED19 localizes to the nucleolus independently of the Mediator complex. This nucleolar targeting is mediated by a conserved poly-lysine motif at the MED19 C-terminus, which enables binding to ribosomal RNA (rRNA) and fibrillarin (FBL), a catalytic component of the 2'-O-methyltransferase complex and pre-rRNA processing factor. Mechanistically, MED19 facilitates rRNA processing and 2'-O-methylation that promotes the efficiency of internal ribosome entry site-dependent translation for a number of onco-promoting genes including c-Myc. Collectively, these findings reveal a novel Mediator-independent function of MED19 in regulating ribosome-mediated translational control, thus providing mechanistic insights into its onco-promoting role. - Source: PubMed
Ming YangJiamin ZhaoYu PengChengjiang LuYiyang ZhangHanqing ZhangZhou QiangWang Gang - Mediator complex subunit 19 (MED19), a member of the mediator complex, has been demonstrated to involve in tumorigenesis of hepatocellular carcinoma (HCC). However, the regulation mechanisms of MED19, the immune landscape linking MED19 to HCC and its predictive value of immunotherapy treatment in HCC are so far unknown. - Source: PubMed
Publication date: 2024/10/05
Jin XiaojunZhang YunHu WeiLiu ChangCai DanyangSun JialinWei QichunCai Qun