Ask about this productRelated genes to: ETHE1 antibody
- Gene:
- ETHE1 NIH gene
- Name:
- ETHE1 persulfide dioxygenase
- Previous symbol:
- -
- Synonyms:
- YF13H12, HSCO
- Chromosome:
- 19q13.31
- Locus Type:
- gene with protein product
- Date approved:
- 2003-12-15
- Date modifiied:
- 2019-01-22
Related products to: ETHE1 antibody
Related articles to: ETHE1 antibody
- As an important turfgrass and forage grass, bermudagrass exhibits high tolerance to submergence stress, however, the molecular mechanisms are poorly clarified and required further elucidation. In this study, physiological analysis and transcriptome sequencing of bermudagrass under submergence stress and post-submergence recovery stage were conducted. Results showed that submergence exerted adverse effects on bermudagrass with decreased stolon length and photosynthetic pigment content. Many differentially expressed unigenes/genes (DEGs) were identified in shoots and roots under submergence and post-submergence stresses. Among these DEGs, 830 DEGs were annotated as transcription factors (TFs) and 104 TFs belong to APETALA 2/ethylene response element binding protein (AP2-EREBP) family. KEGG pathway enrichment analysis revealed that 42 and 4 (11 and 19) KEGG pathways were significantly enriched after submergence and post-submergence recovery in roots (shoots), including plant hormone signaling, sulfur metabolism, carbohydrate metabolism and phenylpropanoid biosynthesis. Moreover, protein-protein interaction (PPI) network was conducted, several hub genes were identified, including those encoding ribosomal proteins, translation initiation factor, persulfide dioxygenase ETHE1 and Enolase 1. Finally, a peroxidase gene CdPER47 were selected and cloned, CdPER47 exhibited significantly differential expression in roots under both submergence and post-submergence stresses. Heterogeneous overexpression of CdPER47 in Arabidopsis increased its survival rate significantly after submergence stress. Based on the above results, a hypothetical model was proposed for bermudagrass responses to submergence and post-submergence stresses. Our study reveals that bermudagrass responds to submergence and post-submergence stresses through extensive transcriptional reprogramming involving AP2-EREBP transcription factors, multiple metabolic pathways, and key hub genes including the functionally validated peroxidase gene CdPER47. Together, this study will provide valuable references for developing submergence-tolerance germplasm in the future. - Source: PubMed
Publication date: 2026/05/07
Jia WeitaoHou SihanYang SongyiZou YuhanDou WenqingZhu KaiZhao CunfengZou ShihuiLiu HuanhuanAi LijiaoWu Shengjun - BackgroundSarcopenia and Alzheimer's disease (AD) are prevalent comorbidities in older adults. Their common genetic basis remains unclear.ObjectiveUtilizing Genomic Structural Equation Modeling, we used European-ancestry genome-wide association study (GWAS) summary statistics to model sarcopenia-related traits. Multiple AD GWAS datasets and the sarcopenia GWAS dataset were used to conduct cross-trait analyses.MethodsGenome-wide and local genetic correlations were assessed using LDSC and LAVA. MiXeR was applied to evaluate shared versus trait-specific variants. Shared loci were identified using conjFDR. Candidate genes were further explored via tissue-specific expression (MetaXcan) and Mendelian randomization (MR).ResultsLDSC analysis revealed no significant genome-wide genetic correlation between AD and sarcopenia (rg = 0.020, p = 0.178). Bivariate LAVA analysis identified significant local genetic correlations at three specific genomic regions (chr3:183.2-184.5 Mb, chr8:144.9-146.3 Mb, and chr8:27.4-28.3 Mb; p < 0.05/90). MiXeR indicated moderate polygenic overlap (228 shared variants). ConjFDR identified 20 shared loci, and MetaXcan highlighted ETHE1, FEZ2, PHLDB3, and PINLYP. MR analysis indicated a positive causal effect of FEZ2 in excitatory neurons on AD and sarcopenia risk (FDR < 0.05).ConclusionsThis study indicates no significant genome-wide genetic correlation between sarcopenia and AD, while suggesting the presence of localized shared genetic signals at specific genomic regions. Dysregulation of the cytoskeleton and autophagy pathways may contribute to both sarcopenia and AD. FEZ2, ETHE1, PHLDB3, and PINLYP expression in muscle and brain may contribute to the comorbidity between sarcopenia and AD. Overall, these findings provide exploratory evidence for local shared genetic architecture between sarcopenia and AD. - Source: PubMed
Publication date: 2026/04/06
Ding KaixiJiang WeiLei MingGao Yongxiang - The role of sodium-glucose cotransporter-1 (SGLT1) in mitochondrial biology function remains unclear. This study aimed to investigate the causal association between SGLT1 inhibition and mitochondrial biology function via Mendelian randomization (MR) analysis. - Source: PubMed
Publication date: 2026/03/13
Fan GangQu Zi-Han - Persulfides (RSSH) have been proposed as key players in biochemical transformations that often involve iron, including iron-sulfur cluster assembly, HS regulation, post translational modifications, and mitochondrial sulfur oxidation. An example of the latter is found in the O-mediated oxidation of glutathione persulfide to sulfite dianion (SO) catalyzed by ETHE1, a nonheme iron persulfide dioxygenase (PDO). The iron-mediated mechanism of persulfide oxidation by PDOs remains poorly understood, and there are no synthetic analogues to date. Herein, we report the synthesis, characterization, and O reactivity of a rare iron(II)-alkylpersulfide complex. The adamantyl persulfide anion (AdSS-) was isolated and characterized by X-ray diffraction as a complex with potassium 18-crown-6 [K(18-crown-6)][AdSS], and employed in the synthesis of a new dinuclear iron(II) complex, [(Fe(MeTACN))(μ-SSAd)][OTf] (). Complex was characterized by single crystal X-ray diffraction (XRD), UV-vis, H/F NMR, and Fe Mössbauer spectroscopy. Reaction of with O in CHCN affords a diiron(III) oxo-bridged complex [(Fe(MeTACN))(μ-O)(μ-SO)(μ-SOAd)][OTf] () identified by XRD, and SO (∼0.5 equiv per Fe). Isotopic labeling studies using O and HO, supported by control experiments and ESI-MS analysis, indicate that SO production proceeds via an iron-centered S-oxygenation mechanism similar to that proposed for persulfide dioxygenases. - Source: PubMed
Publication date: 2026/03/12
Ballot Jasper GSiegler Maxime AGuo YisongMichel Sarah L JGoldberg David P - Reactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging and anti-inflammatory responses. Cystathionine -synthase (CBS), cystathionine -lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST) are well known to mediate endogenous production of hydrogen sulfide (HS), and, together with the mitochondrial isoform of cysteinyl-tRNA synthetase (CARS2), are proposed to be major sources of intracellular persulfides and polysulfides. In mitochondria, enzymes involved in the sulfide oxidation pathway, including sulfide:quinone oxidoreductase (SQOR), persulfide dioxygenase (ETHE1) and thiosulfate sulfurtransferase (TST), also contribute to maintaining and regulating intracellular persulfide levels. Selective inhibitors targeting these enzymes are expected to be powerful tools for elucidating the functions of RSS, as well as having therapeutic potential. In this review, we present a comprehensive overview of these enzymes, focusing on their reaction mechanisms and inhibitors. - Source: PubMed
Publication date: 2026/02/09
Hirabayashi KoSasaki EitaOhno HisashiTakayama OrieYamada SotaHanaoka Kenjiro