Ask about this productRelated genes to: FCN1 antibody
- Gene:
- FCN1 NIH gene
- Name:
- ficolin 1
- Previous symbol:
- -
- Synonyms:
- FCNM
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
Related products to: FCN1 antibody
Related articles to: FCN1 antibody
- Pancreatic cancer remains a highly lethal malignancy due to late diagnosis and the lack of effective non-invasive biomarkers for detection, further complicated by biological heterogeneity, including intraductal papillary mucinous neoplasm (IPMN) and IPMN-associated invasive carcinoma (IPMC). - Source: PubMed
Jung HyunGyoPark NamyoungKim JaihwanKang Min-Jung - Emerging evidence highlights the tumor microenvironment's (TME) role in hepatocellular carcinoma (HCC), yet how tumor-infiltrating myeloid cells drive relapse is unclear. Using full-length single-cell RNA sequencing (scRNA-seq) on samples from primary and early-relapse HCC patients, we identified a dendritic cell subset DC3, which in relapsed tumor exhibited features of mature DCs enriched in immunoregulatory molecules (mregDCs). Mechanistically, mregDCs recruit dysfunctional CD161CD8 T cells, which secrete TNF-α, thereby activating the non-canonical NF-κB pathway to promote the differentiation of mature DCs into mregDCs via tumor necrosis factor receptor 2 (TNFR2). Our results from in vivo mouse models demonstrated that dual blockade of TNFR2 and PD-L1 reduced tumor burden more effectively than anti-PD-L1 monotherapy in mregDC-rich HCC. We also found strong interactions between mregDCs and FCN1+ monocytes, a myeloid-derived suppressor cell (MDSC)-like population. Our study characterizes an mregDC-mediated immunosuppressive network in relapse HCC, nominating TNFR2 as a therapeutic target for myeloid-focused HCC immunotherapy. - Source: PubMed
Publication date: 2026/05/14
Zhang ZefanDing LinZhong YuFeng HaokangHuang LinglongHuang WaidongWang ChunqingÖstman ArneWang BeiliZhou JianFan JiaGuo WeiWu LiangSun Yunfan - High-grade serous ovarian cancer (HGSOC) exhibits homologous recombination deficiency (HRD), but its impact on the immune microenvironment remains unclear. Using single-cell RNA sequencing, spatial transcriptomic inference, and survival analyses, we characterized 166,895 macrophages across HRD subtypes: functional BRCA1/2 inactivation (FBI), HRD-Del (deletions), and HRD-Dup (duplications). FBI macrophages showed lipid metabolism enrichment (S100A8, CD36), HRD-Del macrophages upregulated antigen presentation (HLA-DQA1, HLA-DPB1), and HRD-Dup macrophages displayed interferon-stimulated gene expression (ISG15, MX1). Six macrophage subtypes (C1Q, FCN1, MARCO, MKI67, MMP9, S100A9) exhibited distinct spatial distributions and functions. MKI67+ macrophages correlated with improved survival, while C1Q + subsets predicted worse outcomes. HRD-Dup tumors with high macrophage signatures had better survival, suggesting a favorable immune landscape. Our findings reveal HRD-driven macrophage reprogramming as a key determinant of immune microenvironment composition and clinical outcomes, supporting HRD-specific macrophage-targeted therapies for HGSOC. - Source: PubMed
Lan HuaXu FangLi LinshuangWei XinLi Minghua - Early detection of colon adenocarcinoma (COAD) remains suboptimal. Fecal tests fail to diagnose 30% of stage I cancer, and serum CEA lacks sensitivity (< 40%). Extracellular vesicles (EVs) circulate systemically and package tumor-related cargo, making them attractive non-invasive biomarkers for cancer diagnosis. We profiled the EV proteome from 233 human patients using LC-MS/MS, including stage I‑IV tumors with matched non‑tumor colon tissues (n = 50 each; n = 100), paired pre‑/post‑operative plasma (n = 90) and healthy plasma (n = 43). Circulating EVs contained both tumor-specific and stromal/immune cell-derived proteins, reflecting the systemic nature of EV biology in the cancer setting. Proteomic analysis identified 745 proteins enriched in tumor-derived EVs (e.g., SRPK1, THBS2) and 127 proteins enriched in adjacent tissues. Plasma EVs revealed 166 proteins enriched in COAD (e.g., UBA1, FCN1) and 233 enriched in healthy controls. Pathway analysis linked tumor EV cargo to angiogenesis, mRNA splicing, TGF‑β signalling and RNA translation. Notably, a cross-cancer comparison (pancreatic = 10, lung = 14 cases) revealed that 76% of tumor EV proteins were COAD-specific, highlighting tissue of origin specificity. We further developed a 10-protein EV panel comprising seven tumor-associated and three healthy-enriched EV proteins, which effectively distinguished COAD patients from healthy controls in the two validation cohorts (n = 104 and n = 215), achieving > 90% sensitivity for differentiating COAD from healthy and non-COAD colorectal conditions. Six weeks after curative resection, tumor-associated EV proteins decreased by > 70%, whereas healthy-associated proteins rebounded to baseline, indicating surgical responsiveness. Collectively, EV protein signatures provide a sensitive and tissue-specific window into tumor-host communication, further supporting blood-based early detection of COAD. - Source: PubMed
Seo YuraHan Yoon DaeBojmar LindaKim Kyung-ASeo YurinKim Taeyul KLee SuhoKim YeleemChoi Hye BinLim Yujin HKim Chae HyunSandberg AlexanderFan ChuanwenLauritzen PernilleMolina HenrikPeralta ChristopherGeri Jacob BBurdette ColinHan Dai HoonGee Heon YungLee InsukShin Jeon-SooKim HyunwookLi LeonTobias Gabriel CWortzel InbalShin Sang JoonJung Hyo-IlLee Min GooPaik SoonmyungSchwartz Robert EAhn Joong BaeLyden DavidKim Han Sang - Efficient genetic improvement of complex traits in pigs requires a deep understanding of their genetic architecture and a comprehensive catalog of molecular markers. Here, we conducted a genome-wide association study (GWAS) and conditional analysis in 4,144 Yorkshire pigs, using 10.4 million imputed sequence variants and phenotype data on average backfat thickness at 100 kg (BFT_100). We identified 11 independently significant variants and prioritized 17 candidate genes. By integrating the Pig Genotype-Tissue Expression (PigGTEx) resources, we further performed a transcriptome-wide association study (TWAS) and colocalization analyses, revealing 27 TWAS-significant genes and 13 colocalized genes. These integrative strategies enhanced the functional signals capturing capability based on conventional GWAS, providing a deeper understanding of BFT_100 biology. Notably, NFIA, FCN1, and DBH emerged as novel candidate genes that are not previously implicated for similar traits in either the Animal QTLdb or PigBiobank. Our findings provide a reference for dissecting the genetic architecture of porcine BFT_100 and offer potential markers for precision breeding. - Source: PubMed
Wang JunliangCai XiaodianZhong ZhanmingLin QingGao YahuiWei FukangSi JingleiLi JiaqiQiu XiaotianZhang Zhe