Ask about this productRelated genes to: FRZB antibody
- Gene:
- FRZB NIH gene
- Name:
- frizzled related protein
- Previous symbol:
- -
- Synonyms:
- FRZB-PEN, FRZB1, SRFP3, FRP-3, SFRP3, FRE, FRITZ, FRZB-1, FZRB, hFIZ
- Chromosome:
- 2q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-15
- Date modifiied:
- 2017-10-24
- Gene:
- SFRP4 NIH gene
- Name:
- secreted frizzled related protein 4
- Previous symbol:
- -
- Synonyms:
- frpHE, FRP-4, FRPHE, FRZB-2
- Chromosome:
- 7p14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1998-07-15
- Date modifiied:
- 2017-10-24
Related products to: FRZB antibody
Related articles to: FRZB antibody
- Our previous research demonstrated that growth differentiation factor 15 (GDF15) exhibited superior predictive capability for metabolic dysfunction-associated steatohepatitis (MASH) development with an AUC of 0.86 at 10 years before disease diagnosis. However, the specific pathways and molecular mechanisms associated with GDF15 expression during MASH development remain to be fully investigated in humans. - Source: PubMed
Publication date: 2025/01/21
Wang HaoXu XiaoqianShi LichenHuang ChengSun YamengYou HongJia JidongHe You-WenKong Yuanyuan - The aim of this study was to investigate potential hub genes for dilated cardiomyopathy (DCM). - Source: PubMed
Publication date: 2024/10/18
Qi BinWang Hai-YanMa XiaoChi Yu-FengGui Chun - Dilated cardiomyopathy (DCM) is the second leading cause of heart failure, with intricate pathophysiological underpinnings. In order to shed fresh light on the mechanistic research of DCM, we combined bulk RNA-seq and single-cell RNA-seq (scRNA-seq) data to examine significant cells and genes implicated in the disease. - Source: PubMed
Publication date: 2024/08/14
Huang XiaoyanZhao XiangrongLi YapingFeng YangmengZhang GuoanWang QiyuXu Cuixiang - Dysregulation of the Wnt signaling pathway contributes to the development of many cancer types. Natural compounds produced with biotechnological systems have been the focus of research for being a new drug candidate both with unlimited resources and cost-effective production. In this study, it was aimed to reveal the effects of isopropylchaetominine on cytotoxic, cytostatic, apoptotic and Wnt signaling pathways in brain, pancreatic and prostate cancer. The IC values of isopropylchaetominine in U-87 MG, PANC1, PC3 and LNCaP cells were calculated as 91.94 μM, 41.68 μM, 54.54 μM and 7.86 μM in 72nd h, respectively. The metabolite arrests the cell cycle in G/G phase in each cancer cells. Iso-propylchaetominine induced a 4.3-fold and 1.9-fold increase in apoptosis in PC3 and PANC1 cells, respectively. The toxicity of isopropylchaetominine in healthy fibroblast cells was assessed using the annexin V method, and no significant apoptotic activity was observed between the groups treated with the active substance and untreated. In U-87 MG, PANC1, PC3, and LNCaP cells under treatment with isopropylchaetominin, the expression levels of DKK3, TLE1, AES, DKK1, FRZB, DAB2, AXIN1/2, PPARD, SFRP4, APC and SOX17 tumor suppressor genes increased significantly. Decreases in expression of Wnt1, Wnt2, Wnt3, Wnt4, Wnt5, Wnt6, Wnt10, Wnt11, FRZ2, FRZ3, FRZ7, TCF7L1, BCL9, PYGO, CCND2, c-MYC, WISP1 and CTNNB1 oncogenic genes were detected. All these result shows that isopropylchaetominine can present promising new treatment strategy in different cancer types. - Source: PubMed
Publication date: 2023/12/27
Karamad VahidrezaSogutlu FatmaOzkaya Ferhat CanShademan BehrouzEbrahim WeaamEl-Neketi MonaAvci Cigir Biray - In clinical practice, we observed that the prognoses of patients with heart failure and atrial fibrillation were worse than those of patients with only heart failure or atrial fibrillation. The study aims to get a better understanding of the common pathogenesis of the two diseases and find new therapeutic targets. We downloaded heart failure datasets and atrial fibrillation datasets from the gene expression omnibus database. The common DEGs (differentially expressed genes) in heart failure and atrial fibrillation were identified by a series of bioinformatics methods. To better understand the functions and possible pathways of DEGs, we performed Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. We identified 22 up-regulated genes and 14 down-regulated genes in two datasets of heart failure and 475 up-regulated and 110 down-regulated genes in atrial fibrillation datasets. In addition, two co-upregulated (FRZB, SFRP4) and three co-downregulated genes (ENTPPL, AQP4, C1orf105) were identified. GO enrichment results showed that these common differentially expressed genes were mainly concentrated in the signal regulation of the Wnt pathway. We found five crucial genes in heart failure and atrial fibrillation, which may be potential therapeutic targets for patients with heart failure and atrial fibrillation. - Source: PubMed
Publication date: 2022/09/21
Zhuang YuansongQiao ZhentaoBi XuanyeHan DongjianJiang QingjiaoZhang YiWang FuhangLiu MiaomiaoAn QuanxuShangguan JiahongShen Deliang