Ask about this productRelated genes to: Odf1 antibody
- Gene:
- ODF1 NIH gene
- Name:
- outer dense fiber of sperm tails 1
- Previous symbol:
- -
- Synonyms:
- ODFPG, ODF27, RT7, HSPB10, CT133
- Chromosome:
- 8q22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-10-25
- Date modifiied:
- 2018-04-16
Related products to: Odf1 antibody
Related articles to: Odf1 antibody
- Changes in the poly(A) tail length of Odf1 and other transcripts critical for male fertility have been linked to translational activation during sperm formation. The mRNA poly(A) polymerase TENT5C is required for fastening the flagellum to the sperm head, but its role in shaping the poly(A) tail profile of the spermatid transcriptome remains unclear . Here, we comprehensively document how changes in mRNA poly(A) tail length across the transcriptome reflect transcript metabolism in spermatids. In the absence of TENT5C polymerase activity, Odf1 transcripts show shorter poly(A) tails and, together with ODF1 protein, fail to accumulate at the spermatid neck. Mice expressing a catalytically inactive TENT5C produce headless spermatozoa with flagellar abnormalities associated with ODF1 deficiency . We propose that TENT5C poly(A) polymerase activity regulates the stability and local translation of Odf1 mRNAs at the neck of late-stage spermatids, a process critical for sperm morphogenesis and fertility. These findings highlight the power of poly(A) tail profiling to identify abnormal mRNA processing causative of infertility. - Source: PubMed
Publication date: 2026/04/20
Baptissart MarineGupta AnkitPerez Maira LPoirot Alexander CPapas Brian NGuardia Carlos MMorgan Marcos - Butylphthalide has shown significant potential in the treatment of ischemic stroke, but its precise mechanisms of action remain unclear. Long non-coding RNAs (lncRNAs) and messenger RNAs (mRNAs) play crucial roles in the pathogenesis of ischemic stroke and may serve as potential therapeutic targets. This study investigated the effects of butylphthalide treatment on the lncRNA-mRNA co-expression network in ischemic stroke patients. - Source: PubMed
Publication date: 2025/04/10
An YangfangHuang LingyunLi JunChen ZhuoCai JizhangWang BiaoZhou Qiong - Changes in the poly(A) tail length of and other transcripts critical for male fertility have been linked to translational activation during sperm formation . The mRNA poly(A) polymerase TENT5C is required for fastening the flagellum to the sperm head, but its role in shaping the poly(A) tail profile of the spermatid transcriptome remains limited . Here, we comprehensively document how changes in mRNA poly(A) tail length across the transcriptome reflect transcript metabolism in spermatids. In the absence of TENT5C polymerase activity, the poly(A) tail length of transcripts is reduced, and the local distribution of ODF1 proteins in spermatids is disrupted. We show that mice expressing a catalytically inactive TENT5C produce headless spermatozoa with outer dense fibers detached from the axoneme, and other flagellar abnormalities associated with ODF1 deficiency . We propose that TENT5C poly(A) polymerase activity regulates the spatial translation of mRNAs during spermiogenesis, a process critical for sperm morphogenesis and fertility. These findings highlight the power of poly(A) tail profiling to identify abnormal mRNA processing causative of infertility. - Source: PubMed
Publication date: 2025/03/24
Baptissart MarineGupta AnkitPoirot Alexander CPapas Brian NMorgan Marcos - Azoospermia, characterized by the absence of spermatozoa in the ejaculate, affects approximately 1% of all men and 10 - 15% of infertile males, representing the most severe form of male infertility. It is classified into obstructive azoospermia (OA) and nonobstructive azoospermia (NOA), with the latter often resulting from unexplained failures in spermatogenesis. This study endeavored to clarify the molecular underpinnings of sper-matogenesis in NOA and to identify viable therapeutic targets. - Source: PubMed
Li ChaoChengLi MengYuLiu YaXingLi JianZhang YaRuWang HuiZhang YongShengJia Bin - The WD40 repeat (WDR) domain is present in a wide range of proteins, providing sites for protein‒protein interactions. Recent studies have shown that WDR proteins play indispensable roles in spermatogenesis, such as in spermatocyte division, sperm head formation and flagellar assembly. In this study, we identified a novel testis-specific gene, , which has the typical characteristics of WD40 proteins with two β-propellers, and is highly conserved in Mammalia. RT-PCR and Western blot results revealed that was highly expressed in testis. WDR64 protein was weakly expressed at postnatal Day 7, increased substantially at postnatal Day 28 and maintained at high levels thereafter. Further immunofluorescence demonstrated that WDR64 was localized posterior to the nucleus in steps 8-14 spermatids in line with the dynamic localization of manchette, moved to the flagella in steps 15-16 spermatids, and localized at the midpiece of the flagellum in mature spermatozoa. To explore the function of WDR64, we performed immunoprecipitation‒mass spectrometry (IP‒MS) to screen its interacting proteins and found that WDR64 interacted with ODF1 to form a complex. The WDR64/ODF1 complex is located at the manchette during nucleus shaping and finally at the midpiece of the mature spermatozoa tail, suggesting that it may be involved in the assembly of the manchette and flagella during spermiogenesis. Our findings provide the first understanding of the expression pattern of WDR64 and its potential molecular mechanism in spermiogenesis. - Source: PubMed
Publication date: 2024/09/21
Zhang YunfeiXing XiaoweiHuang LihuaSu YuyanLiu GangZhang XinxingYang Youbo