Ask about this productRelated genes to: SPA17 antibody
- Gene:
- SPA17 NIH gene
- Name:
- sperm autoantigenic protein 17
- Previous symbol:
- -
- Synonyms:
- SP17, CT22
- Chromosome:
- 11q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 2000-05-02
- Date modifiied:
- 2015-08-26
Related products to: SPA17 antibody
Related articles to: SPA17 antibody
- Sperm Autoantigenic Protein 17 (SPA17), a member of the cancer-testis antigen family, is frequently overexpressed in various malignancies, yet its biological functions, regulatory mechanisms, and clinical relevance in melanoma remain largely unexplored. This study aimed to investigate the expression pattern, prognostic value, and functional role of SPA17 in melanoma progression and immune modulation. - Source: PubMed
Publication date: 2026/09/09
Zhang LanYou MengshuYan BinZhang JianYao YiZhang QingyanXie ZuozhongWang ShixiangGao Qian - Air pollution, such as particulate matter with a diameter of ≤2.5 μm (PM) is a major contributor to lung cancer in the never-smoking population. Anthracotic pigments (black deposits in the lungs) are physical evidence of environmental exposures. While links between anthracosis and lung disease have been established, anthracosis has not been routinely used as a measure of environmental exposure in research, because there is neither a standard quantitative measure of anthracosis nor an efficient method for quantifying it. We developed 'Slide-based methods for High-throughput Anthracosis Detection and Estimation' (SHADE). SHADE is an automated workflow that quantifies anthracotic pigments on scanned images of whole H&E slides. SHADE was optimized to identify anthracosis while avoiding detection of artefacts in images. SHADE scores and manual pathologist rankings of 10-image patches demonstrated high concordance (R = 0.864). Application of SHADE to background lung sections from 140 never-smoking lung cancer patients demonstrated significant associations between high anthracosis and older age, male sex, 30-year residential PM estimates, and birthplace in Asia (p < 0.05). Low anthracosis was associated with less aggressive adenocarcinomas (p = 0.052). No significant relationship was identified between anthracosis and 3-year residential PM estimates, lobe sampled, ethnicity, EGFR mutation status or pathologic tumor stage. Anthracosis levels in the never-smoking cohort were similar to that of background lung sections from 59 ever-smoking patients. Exploratory analysis of background lung sections of 15 individuals who had bronchoalveolar lavage specimen gene expression data available, SHADE scores were associated with the expression of several immunoregulatory genes (CEACAM6, CXCL6, IL5RA, LCN2, SPA17), the activation of inflammatory response and cytokine gene sets, and suppression of the antigen processing and presentation gene set (false discovery rate < 0.1). SHADE provides an automated workflow for anthracosis quantification and has demonstrated utility in uncovering insight into anthracosis-associated molecular changes in lung cancer. - Source: PubMed
Fung Lucas CJoseph BrendenOfori-Amanfo KennethLo TheodoraWang PeiyaoTrinder MarkBarnabas GeorginaNikaido-Landry TaysiaDurney Clinton HTawara AadetriOng SharonLam StephenMeza RafaelMyers RenelleLockwood William WMcGuire AnnaNaso Julia RLim Emilia L - Vascular tissue-resident macrophages (VRMs) maintain immune balance in blood vessels, but their role in abdominal aortic aneurysm (AAA) development remains unclear. Here we demonstrated that a specific group of VRMs located in the adventitia marked by expression of Lyve1, protected against AAA by secreting the extracellular matrix protein Sparcl1 (Sc1). Deletion of Sc1 in VRMs promoted dysfunctional lymphangiogenesis and led to the formation of tertiary lymphoid structures (TLSs), thereby accelerating AAA progression. Mechanistically, the calcium-binding domain of Sc1 acted as a trap for the growth factor FGF2, inhibiting FGF2-mediated dysfunctional lymphangiogenesis and expression of genes associated with TLS formation. A therapeutic peptide derived from Sc1 (Spa17) mitigated AAA progression in several AAA models. Our findings reveal that VRM-derived Sc1 has a protective role in AAA and identify a potential therapeutic approach. - Source: PubMed
Publication date: 2026/02/27
Chen Mei-HuaHua Yi-JieLi YanLei YuZhou Si-YuanHu Xi-DeHu Dong-HuaDong Zhi-HuiLu YanZhuang TaoRuan Cheng-Chao - Excessive dieting (ED), a common weight-control strategy, often causes neurological and emotional disturbances, yet its gut-brain interaction mechanisms remain unclear. Employing a short-term dietary (SDR) adult male rabbit model, we found that SDR can induced cerebral cortex up-regulation of the immune-related genes (e.g., C1QC, SAA3) enriched in NF-kappa B signaling pathways, contrasted with down-regulation of sex hormone-related genes (e.g., PRLR, SPA17) implicated in metabolic homeostasis. Furthermore, dysregulated expression of metabolic genes (e.g., PPM1J, GALNT18) in the cecum of the SDR group interacted to impair the immune protection pathways related to intestinal mucosa. Then, SDR significantly increased the cecal Firmicutes/Bacteroidetes ratio (from 3.38 to 5.57) and reduced microbial diversity. Specifically, beneficial bacteria involved in tryptophan metabolism and neurotransmitter synthesis (e.g., Bacteroidales_bacterium, Alistipes_indistinctus) decreased, whereas bile acid-metabolizing bacteria (e.g., Clostridium_sp._CAG:710, Ruminococcus_sp._Marseille-P6503) linked to increase energy metabolism. The top 20 genes from the brain-gut axis analysis (e.g., ITPR1, CAMK4, CDK5R1) were enriched in critical neural pathways like axon guidance, GABAergic synapse, and long-term potentiation. Notably, key neurodevelopmental genes (e.g., GPR37, GPX3) correlated with these microbial shifts, implicating oxidative stress, synaptic plasticity, and mitochondrial function in microbiota-host crosstalk. This study highlights a "microbial-metabolism-neural" axis in SDR, providing novel targets for future obesity intervention strategies. - Source: PubMed
Publication date: 2025/12/08
Li YanhongChen JianningQi XiaolanHe YanWang GuozeWei LiminHong Wei - We aimed to develop a predictive model integrating G2M-related genes to enhance the prognostication of colon cancer. - Source: PubMed
Publication date: 2025/08/10
Song XinDou YanShen Xiaoyong