Ask about this productRelated genes to: Cish antibody
- Gene:
- CISH NIH gene
- Name:
- cytokine inducible SH2 containing protein
- Previous symbol:
- -
- Synonyms:
- CIS, G18, CIS-1, SOCS
- Chromosome:
- 3p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 1996-09-23
- Date modifiied:
- 2016-10-05
- Gene:
- SOCS1 NIH gene
- Name:
- suppressor of cytokine signaling 1
- Previous symbol:
- -
- Synonyms:
- SOCS-1, SSI-1, JAB, TIP3, Cish1
- Chromosome:
- 16p13.13
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-13
- Date modifiied:
- 2015-08-26
- Gene:
- SOCS2 NIH gene
- Name:
- suppressor of cytokine signaling 2
- Previous symbol:
- -
- Synonyms:
- STATI2, SSI2, SOCS-2, SSI-2, CIS2, Cish2
- Chromosome:
- 12q
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-13
- Date modifiied:
- 2015-09-02
- Gene:
- SOCS3 NIH gene
- Name:
- suppressor of cytokine signaling 3
- Previous symbol:
- -
- Synonyms:
- SSI-3, CIS3, SOCS-3, Cish3
- Chromosome:
- 17q25.3
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-13
- Date modifiied:
- 2019-04-23
- Gene:
- SOCS5 NIH gene
- Name:
- suppressor of cytokine signaling 5
- Previous symbol:
- -
- Synonyms:
- KIAA0671, SOCS-5, CIS6, CISH6, Cish5
- Chromosome:
- 2p21
- Locus Type:
- gene with protein product
- Date approved:
- 2002-11-13
- Date modifiied:
- 2014-11-19
Related products to: Cish antibody
Related articles to: Cish antibody
- To investigate the response of the suppressor of the cytokine signaling (socs) gene family in rainbow trout following exposure to microplastics, this study conducted a bioinformatics analysis of the socs gene family using rainbow trout genome data, complemented by experiments involving microplastic exposure and gene expression detection. - Source: PubMed
Publication date: 2025/05/22
Ma FangWang WenliDong JiaxuanZhou XiangjunLin ZhiyunZheng PanNian XiajiaoDong Lili - Human respiratory syncytial virus (HRSV) and human metapneumovirus (HMPV) are leading causes of upper and lower respiratory tract infections in non-immunocompetent subjects, yet the mechanisms by which they induce their pathogenicity differ significantly and remain elusive. In this study we aimed at identifying the gene interaction networks between the HRSV, HMPV respiratory pathogens and their host along with the different cell-signaling pathways associated with the above interactomes. - Source: PubMed
Publication date: 2020/01/25
Rouka ErasmiaHatzoglou ChrissiGourgoulianis Konstantinos IZarogiannis Sotirios G - The SOCS family are key negative regulators of cytokine and growth factor signaling. Typically, 8-17 SOCS genes are present in vertebrate species with eight known in mammals, classified as type I (SOCS4-7) and type II (CISH and SOCS1-3) SOCS. It was believed that the type II SOCS were expanded through the two rounds of whole genome duplication (1R and 2R WGDs) from a single CISH/SOCS1-3 precursor. Previously, 12 genes were identified in rainbow trout but here we report 15 additional loci are present, and confirm 26 of the genes are expressed, giving rainbow trout the largest SOCS gene repertoire identified to date. The discovery of the additional SOCS genes in trout has led to a novel model of SOCS family evolution, whereby the vertebrate SOCS gene family was derived from CISH/SOCS2, SOCS1/SOCS3, SOCS4/5, SOCS6, and SOCS7 ancestors likely present before the two WGD events. It is also apparent that teleost SOCS2b, SOCS4, and SOCS5b molecules are not true orthologues of mammalian SOCS2, SOCS4, and SOCS5, respectively. The rate of SOCS gene structural changes increased from 2R vertebrates, to 4R rainbow trout, and the genes with structural changes show large differences and low correlation coefficient of expression levels relative to their paralogues, suggesting a role of structural changes in expression and functional diversification. This study has important impacts in the functional prediction and understanding of the SOCS gene family in different vertebrates, and provides a framework for determining how many SOCS genes could be expected in a particular vertebrate species/lineage. - Source: PubMed
Wang BeiWangkahart EakapolSecombes Christopher JWang Tiehui - In mammals, suppressor of cytokine signalling (CISH, SOCS1 to SOCS7) factors control signalling pathways involved in the regulation of numerous physiological processes including pregnancy. In order to gain new insights into the biological functions of SOCS in the endometrium, a comprehensive analysis of SOCS gene expression was carried out in bovine caruncular (CAR) and intercaruncular (ICAR) tissues collected i) during the oestrous cycle, ii) at the time of maternal recognition of pregnancy and at implantation in inseminated females, iii) following uterine interferon-tau (IFNT) infusion at day 14 post-oestrus, iv) following a period of controlled intravaginal progesterone release and v) following transfer of embryos by somatic-cell nuclear transfer (SCNT). The regulatory effects of IFNT on in vitro cultured epithelial and stromal cells were also examined. Altogether, our data showed that CISH, SOCS4, SOCS5 and SOCS7 mRNA levels were poorly affected during luteolysis and pregnancy. In contrast, SOCS1, SOCS2, SOCS3 and SOCS6 mRNA levels were strongly up-regulated at implantation (day 20 of pregnancy). Experimental in vitro and in vivo models demonstrated that only CISH, SOCS1, SOCS2 and SOCS3 were IFNT-induced genes. Immunohistochemistry showed an intense SOCS3 and SOCS6 staining in the nucleus of luminal and glandular epithelium and of stromal cells of pregnant endometrium. Finally, SOCS3 expression was significantly increased in SCNT pregnancies in keeping with the altered immune function previously reported in this model of compromised implantation. Collectively, our data suggest that spatio-temporal changes in endometrial SOCS gene expression reflect the acquisition of receptivity, maternal recognition of pregnancy and implantation. - Source: PubMed
Publication date: 2014/09/03
Carvalho A VitorinoReinaud PForde NHealey G DEozenou CGiraud-Delville CMansouri-Attia NGall LRichard CLonergan PSheldon I MLea R GSandra O