Ask about this productRelated genes to: DNAJB4 antibody
- Gene:
- DNAJB4 NIH gene
- Name:
- DnaJ heat shock protein family (Hsp40) member B4
- Previous symbol:
- -
- Synonyms:
- HLJ1
- Chromosome:
- 1p31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-09
- Date modifiied:
- 2015-11-19
Related products to: DNAJB4 antibody
Related articles to: DNAJB4 antibody
- Endometrial cancer (EC) is a malignant neoplasm with a high prevalence, posing a significant threat to women's health and a substantial burden on the healthcare system. The endoplasmic reticulum-associated degradation (ERAD) pathway is essential for sustaining cellular homeostasis and tumorigenesis. This study elucidated the mechanisms of the DnaJ Heat Shock Protein Family (Hsp40) Member B4 (DNAJB4) and the activator of heat shock protein 90 (HSP90) ATPase activity 1 (AHSA1) in EC cells. DNAJB4 was knocked down in Ishikawa cells, and its impact on cellular biological functions was assessed using colony formation assays, flow cytometry, and western blot. The association between AHSA1 and DNAJB4 was identified using the Co-Immunoprecipitation (Co-IP) method. Ishikawa and RL95-2 cells overexpressing AHSA1 were generated, followed by functional assays and analysis of associated protein expressions. The knockdown of DNAJB4 markedly impeded the colony formation of Ishikawa and RL95-2 cells, enhanced apoptosis, and elevated the expressions of critical ERAD proteins X-box binding protein 1 (XBP-1s), activating transcription factor 4 (ATF4), C/EBP-homologous protein (CHOP), and growth arrest and DNA damage-inducible protein 34 (GADD34). AHSA1 bound to DNAJB4. The overexpression of AHSA1 enhanced the production of the DNAJB4 protein, facilitated cell colony formation, diminished cell apoptosis, and suppressed the expressions of ERAD-related proteins; however, the deletion of DNAJB4 negated these effects of AHSA1 overexpression. Collectively, AHSA1 and DNAJB4 cooperatively maintain efficient ERAD function, thereby alleviating endoplasmic reticulum stress and promoting EC progression. - Source: PubMed
Publication date: 2026/04/09
Ye ZhongxueYu ChenCao SiyuJiang Yafen - - Source: PubMed
Publication date: 2026/03/16
Roy SubhajitNashi SaraswatiMenon DeepakVengalil SeenaNalini Atchayaram - Lung adenocarcinoma (LUAD) is a prevalent malignancy whose therapeutic management is complicated by nonspecific early symptoms, late-stage diagnosis, and aggressive metastasis. Given the critical role of palmitoylation in LUAD progression, this study aims to construct a prognostic model based on palmitoylation-related genes, identify key biomarkers, and elucidate their underlying mechanisms. - Source: PubMed
Publication date: 2026/02/12
Huang ZhilanXie TingyiTang MingwenSu AnqiJin ZhujinChen ZhuniJia DanXie Wei - The lack of reliable early markers specific to hepatocellular carcinoma (HCC) limits its effective management. While the genetic factors defining this disease are largely understood, the epigenetic mechanisms that cause HCC remain elusive. MicroRNAs (miRNAs) operate as polycistronic clusters rather than individual genes and are critical to the development and progression of multiple cancers, including HCC. In this study, we identified several miRNA clusters, including the miR-106b/25 cluster (miR-106b-5p, miR-25-3p, and miR-93-5p), that are overexpressed in HCC cells, suggesting their oncogenic function. We then performed whole-transcriptomic sequencing and identified gene targets of this cluster, namely, CAV1, DNAJB4, PTPRD, MFSD2A, TCF4, KLF6, MCC, CYB5A, ESR2, NR4A3, PRKCB, RASSF2, TXNIP, and SOD2, to be downregulated in the HCC spheroids and clinical datasets. Further, gene enrichment analysis revealed associations with critical pathways, such as Wnt signaling, TGF-beta signaling, VEGFA-VEGFR2 signaling, and EGF/R signaling pathways. Furthermore, survival analysis revealed that miR-93-5p (HR = 0.72, p = 0.0246), HCC stage (HR = 2.43, p = 0.0000113), TCF4 (HR = 0.66, p = 0.0106), DNAJB4 (HR = 1.29, p = 0.0214), MCC (HR = 1.35, p = 0.0268), and CYB5A (HR = 0.77, p = 0.0423) affect overall survival (OS). Finally, a combined prognostic model for the miRNA cluster and its target genes via the random forest approach revealed that the miR-106b/25 cluster and its interactome are significantly associated with OS (p < 0.0001), thereby providing a comprehensive understanding of the cluster and its targets in the development and progression of HCC and its use as a potential marker for HCC. - Source: PubMed
Publication date: 2025/11/06
Karunakara Shreyas HulusemaneMoorthy ManjuRamaswamy GopalakrishnaPuttamallapa Vinutha ShanubhoganahalliPrakash MaheshkumariMehtani RohitKabekkodu Shama PrasadaVishwanath Prashant MSanthekadur Prasanna Kumar - Bladder cancer (BLCA) has a poor prognosis and continues to pose a significant challenge for clinicians. Prior studies have demonstrated a close relationship of BLCA with macrophages. However, the key subpopulations and molecular functions of macrophages in BLCA have not been uncovered. It becomes possible to use single-cell sequencing technology to explore macrophage heterogeneity and identify new biomarkers. - Source: PubMed
Publication date: 2025/10/04
Che GuangliangZhao XuejunLuo RongtuanYu QuanfengGuo XiaofengGao KeChen KangyuZhang Erfeng