Ask about this productRelated genes to: PNRC1 antibody
- Gene:
- PNRC1 NIH gene
- Name:
- proline rich nuclear receptor coactivator 1
- Previous symbol:
- PROL2
- Synonyms:
- B4-2, PRR2
- Chromosome:
- 6q15
- Locus Type:
- gene with protein product
- Date approved:
- 2002-01-03
- Date modifiied:
- 2016-10-05
Related products to: PNRC1 antibody
Related articles to: PNRC1 antibody
- Exploring the correlation between ovarian cancer and aging has great significance for understanding the pathogenesis of ovarian cancer and formulating targeted therapeutic regimens. - Source: PubMed
Publication date: 2025/05/09
Qin LanhuiYang ChongzeSong RuiChen Pei-YinJiang ZijianXu WeihuiZeng GuanzhenLiao Jin-YuanLong Liling - To identify blood-based biomarkers and therapeutic targets for Alzheimer's disease (AD) by leveraging single-cell RNA sequencing (scRNA-seq) data from peripheral blood mononuclear cells (PBMCs) and advanced deep learning techniques. - Source: PubMed
Publication date: 2025/04/30
Talebi HediyehGhiam ShokoofehKoli Asiyeh MirzaeiYeganeh Pourya NaderiEslahchi Changiz - The role of processing bodies (P-bodies) in tumorigenesis and tumor progression is not well understood. Here, we showed that the oncogenes YAP/TAZ promote P-body formation in a series of cancer cell lines. Mechanistically, both transcriptional activation of the P-body-related genes , and and transcriptional suppression of the tumor suppressor gene are involved in enhancing the effects of YAP/TAZ on P-body formation in colorectal cancer (CRC) cells. By reexpression of PNRC1 or knockdown of P-body core genes ( and ), we determined that disruption of P-bodies attenuates cell proliferation, cell migration, and tumor growth induced by overexpression of YAP in CRC. Analysis of a pancancer CRISPR screen database (DepMap) revealed co-dependencies between YAP/TEAD and the P-body core genes and correlations between the mRNA levels of and YAP target genes. Our study suggests that the P-body is a new downstream effector of YAP/TAZ, which implies that reexpression of PNRC1 or disruption of P-bodies is a potential therapeutic strategy for tumors with active YAP. - Source: PubMed
Publication date: 2024/07/24
Shen XiaPeng XiangGuo YueGuiDai ZhujiangCui LongYu WeiLiu YunLiu Chen-Ying - Heat stress significantly disturbs the production, reproduction, and systems biology of dairy cattle. A complex interaction among biological systems helps to combat and overcome heat stress. Indicine cattle breed Tharparkar has been well known for its thermal adaptability. Therefore, present investigation considered RNA-seq technology to explore the functional transcriptomics of Tharparkar cattle with the help of samples collected in spring and summer season. Among differentially expressed genes, about 3280 genes were highly dysregulated, in which 1207 gene were upregulated and 2073 genes were downregulated (|log2fold change|≥ 1 and ≤ 0.05). Upregulated genes were related to insulin activation, interferons, and potassium ion transport. In contrast, downregulated genes were related to RNA processing, translation, and ubiquitination. Functional annotation revealed that the pathways associated with nervous system (, ) and metal ion transport (, ) were highly activated while mRNA processing and translation (, ) and protein processing pathway (, ) were highly downregulated. Protein-protein interactions identified hub genes such as , , , , found to play an important role in immune, ubiquitination, translation and transport function. Co-expression network includes , , , and genes which are involved in lysosomal activity, tumor inhibition, ubiquitination, and translation initiation. Chemokine signaling pathway associated with immune response was highly upregulated in cluster analysis. The findings of this study provide insights into transcriptome expression and regulation which may better explain complex thermal resilience mechanism of Tharparkar cattle in heat stress under natural conditions. - Source: PubMed
Publication date: 2024/06/06
Singh AyushiVerma ArchanaDutta GauravGowane Gopal RLudri AshutoshAlex Rani - Corona Virus Disease 2019 (COVID-19) and Osteoarthritis (OA) are diseases that seriously affect the physical and mental health and life quality of patients, particularly elderly patients. However, the association between COVID-19 and osteoarthritis at the genetic level has not been investigated. This study is intended to analyze the pathogenesis shared by OA and COVID-19 and to identify drugs that could be used to treat SARS-CoV-2-infected OA patients. - Source: PubMed
Publication date: 2023/05/22
Zhang YiweiDuan ZhengweiGuan YonghaoXu TianyangFu YuesongLi Guodong