Ask about this productRelated genes to: EDIL3 antibody
- Gene:
- EDIL3 NIH gene
- Name:
- EGF like repeats and discoidin domains 3
- Previous symbol:
- -
- Synonyms:
- DEL1
- Chromosome:
- 5q14.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-12-16
- Date modifiied:
- 2016-10-05
Related products to: EDIL3 antibody
Related articles to: EDIL3 antibody
- Osteoarthritis (OA) is a major cause of disability worldwide, and pathological alterations in the subchondral bone microenvironment play a critical role in disease progression. Emerging evidence indicates that the extracellular matrix protein EDIL3 is involved in angiogenesis, inflammatory regulation, and cell adhesion, but its role in OA pathogenesis remains unclear. This study aimed to determine whether EDIL3 regulates subchondral vascular permeability and to elucidate its underlying mechanism in OA progression. - Source: PubMed
Publication date: 2026/04/13
Ma YeFeng KaiTian KuanminHe XiaoxinYan JiangboWang RuiMa PenggangTang ZhiqunZhu GuangYang YangSun RuiSu YajingXue DiChen ZhirongLin XueJin Qunhua - Triple-negative breast cancer (TNBC) lacks effective targeted therapies, and the mechanisms by which developmental endothelial locus-1 (EDIL3/Del-1) promotes TNBC remain incompletely defined. We profiled Del-1 and AMPK subunits in TNBC cell lines by RT-PCR and immunoblotting, performed functional assays in CRISPR/Cas9 Del-1 knockout and AMPKβ-manipulated cells, and evaluated AMPKβ in early-stage TNBC tumors using tissue microarrays (TMA) (immunohistochemistry; = 100) and mRNA quantification. Del-1 and AMPKβ were enriched in TNBC cells, most prominently in the mesenchymal stem-like subtype, whereas AMPKα levels were relatively stable. Increased Del-1 and activated AMPKβ enhanced proliferation and invasion, while Del-1 deletion reduced AMPKβ expression and suppressed tumor-promoting phenotypes. Mechanistically, Del-1 increased AMPKβ phosphorylation at serine 108, and a phospho-mimetic AMPKβ mutant further amplified oncogenic effects. In the pilot TMA study, high AMPKβ protein expression showed a trend toward poorer DFS in Kaplan-Meier analysis, while multivariate analysis identified high AMPKβ protein expression as an independent factor associated with poorer DFS in patients with early TNBC. These data support AMPKβ as a key mediator of Del-1-driven signaling and suggest AMPKβ could be a therapeutic target in aggressive TNBC subsets. - Source: PubMed
Publication date: 2026/03/15
Jeong Seol-HwaLee Soo JungLee In HeeLee JeeyeonKang ByeongjuMoon Joon SukPark Ho YongPark Ji YoungPark Nora Jee YoungKim Eun AeKang JieunChae Yee Soo - Stem cell therapy has been utilized in the treatment of periodontitis. Recent studies have demonstrated that treatment with apoptotic mesenchymal stem cells (MSCs) exhibits immunomodulatory effects comparable to those of living MSCs. However, the effect of type 2 diabetes mellitus (T2DM) on the efficacy of apoptotic MSCs therapy for periodontitis remains poorly understood. In this study, a ligature-induced experimental periodontitis model was established in wild-type (WT) and db/db mice, followed by the injection of exogenous apoptotic periodontal ligament stem cells (PDLSCs). The results revealed suboptimal therapeutic outcomes with apoptotic PDLSCs in db/db mice. It was observed that the progression of periodontitis was associated with a reduction in the expression of developmental endothelial locus-1 (DEL-1) in experimental periodontitis model. Additionally, the expression of DEL-1 was partially restored during the resolution phase of inflammation. T2DM mice exhibited exacerbated alveolar bone loss and suppressed regeneration, accompanied by the inhibition of DEL-1 expression. In co-culture experiments, impaired macrophage efferocytosis of apoptotic PDLSCs was ameliorated by the addition of exogenous DEL-1 under lipopolysaccharide and high glucose conditions. Moreover, the co-administration of exogenous DEL-1 enhanced the therapeutic efficacy of exogenous apoptotic PDLSCs in db/db mice. In conclusion, diminished DEL-1 expression and impaired macrophage efferocytosis constrain the therapeutic potential of exogenous apoptotic PDLSCs in periodontitis with T2DM. The diminished therapeutic efficacy may be alleviated by the combination of exogenous DEL-1 and apoptotic PDLSCs, offering novel insights into potential therapeutic strategies for periodontitis with T2DM. - Source: PubMed
Ma QianLi HouxuanYang XiaoyuWang HeHu YiyaoLi HanZeng DepingLi JieSong Jinlin - Ependymoma is a malignancy of the neuroepithelium-derived ependyma that lines the spinal cord and ventricles of the brain, occurring most frequently in young children and older adults. Genetic susceptibility to ependymoma has proven difficult to assess due to disease rarity. - Source: PubMed
Publication date: 2026/01/16
Strauss Joshua DShetty Priya BTsavachidis SpiridonByun JinyoungMack Stephen CXiangjun XiaoArmstrong Terri SGilbert Mark R Mirabello LisaBhatia SmitaLeisenring Wendy MMorton Lindsay MArmstrong Gregory TFoss-Skiftesvik JonHagen Christian MunchBybjerg-Grauholm Jonas Ghozal ManelBonaventure AudreyClavel JacquelineBondy Melissa L Amos Christopher IHoang Thanh TScheurer Michael E - To determine the serum expression profile of miR-377-3p in carotid artery stenosis (CAS) patients and to assess its diagnostic potential in a clinical setting. - Source: PubMed
Publication date: 2026/01/08
Qie GuohuaHan HuixianNing JianfengWang WenqiangLei Yan