Ask about this productRelated genes to: C8orf77 antibody
- Gene:
- ZNF252P-AS1 NIH gene
- Name:
- ZNF252P antisense RNA 1
- Previous symbol:
- C8orf77
- Synonyms:
- -
- Chromosome:
- 8q24.3
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2005-10-06
- Date modifiied:
- 2012-10-12
Related products to: C8orf77 antibody
Related articles to: C8orf77 antibody
- Long non-coding RNAs (lncRNAs) have emerged as useful diagnostic and prognostic markers as well as therapeutic targets in cancer. Dysregulated levels of lncRNAs have been described in various cancers including breast cancer (BC). Our study aims to screen novel lncRNAs involved in BC and investigate any possible role in helping diagnosis and determining prognosis of BC patients. - Source: PubMed
Publication date: 2025/11/25
El-Ashmawy Nahla EAbo-Saif Mariam AHamouda Sara MKhedr Eman G - Keloid scars (keloids), a prototypical form of aberrant scar tissue formation, continue to pose a significant therapeutic challenge within dermatology and plastic surgery due to suboptimal treatment outcomes. Gelatinases are a subgroup of matrix metalloproteinases (MMPs), a family of enzymes that play an important role in the degradation and remodeling of the ECM (a pivotal factor for keloids development). Gelatinases include gelatinase A (MMP-2) and gelatinase B (MMP-9). Since accumulating evidence has shown that gelatinases played a crucial role in the process of keloid formation, we summarized the current knowledge on the association between MMP-2 and MMP-9 expression and the pathological process of keloids through a comprehensive review. This review demonstrated that the interplay between MMP-2, MMP-9, and their regulators, such as TGF-β1/Smad, PI3K/AKT, and LncRNA-ZNF252P-AS1/miR-15b-5p/BTF3 signaling cascades, involved in the intricate balance governing ECM homeostasis, collectively driving the excessive collagen deposition and altered tissue architecture observed in keloids. In summary, this review consolidates the current understanding of MMP-2 and MMP-9 in keloid pathogenesis, shedding light on their intricate involvement in the dysregulated keloids processes. The potential for targeted therapeutic interventions presents promising opportunities for advancing keloid management strategies. - Source: PubMed
Publication date: 2024/11/25
Wang YajieZheng LiyingZhang LaiTai YunchengLin XuesongCai Zhencheng - As the most important modifications on the RNA level, N6-methyladenosine (m6A-) and 5-methylcytosine (m5C-) modification could have a direct influence on the RNAs. Long non-coding RNAs (lncRNAs) could also be modified by methylcytosine modification. Compared with mRNAs, the function of lncRNAs could be more potent to some extent in biological processes like tumorigenesis. Until now, rare reports have been done associated with cutaneous melanoma. Herein, we wonder if the m6A- and m5C- modified lncRNAs could influence the immune landscape and prognosis in melanoma, and we also want to find some lncRNAs which could directly affect the malignant behaviors of melanoma. - Source: PubMed
Shi Hao-ZeTian Cui-CuiWu Ming-YangMa LiSun Jian-FangChen Hao - JAK2/STAT3 signaling pathway plays an important role in keloid formation, but the upstream mechanism of their activation remains unclear. - Source: PubMed
Publication date: 2022/12/29
Guo YuLi MengjuanLong JianhongFan PengjuZuo ChenchenWang Yongjie - Ovarian cancer is a common gynecological malignant disease in women. Our work aimed to study the specific functions of ZNF252P antisense RNA 1 (ZNF252P-AS1) in ovarian cancer. - Source: PubMed
Publication date: 2022/01/03
Geng LiWang ZhongqiuTian Yongju