Ask about this productRelated genes to: HNF1A antibody
- Gene:
- HNF1A NIH gene
- Name:
- HNF1 homeobox A
- Previous symbol:
- MODY3, TCF1
- Synonyms:
- HNF1, LFB1
- Chromosome:
- 12q24.31
- Locus Type:
- gene with protein product
- Date approved:
- 1990-02-12
- Date modifiied:
- 2019-04-23
Related products to: HNF1A antibody
Related articles to: HNF1A antibody
- C-reactive protein (CRP) is a well-established biomarker of systemic inflammation. In pregnancy, several studies show association of elevated CRP with gestational diabetes mellitus (GDM). However, the genetic contributions of CRP levels during early pregnancy and their potential association with GDM remain largely understudied. The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) provides a unique opportunity to investigate these questions due to its rich design, including early pregnancy biospecimens, genome-wide genotype data, and detailed clinical outcomes across multiple ancestry groups. - Source: PubMed
Publication date: 2026/09/24
Zhang YuMoore AmyRyckman Kelli KYan QiGuerrero Rafael FLi MingSilver Robert MLuo JuhuaYee Lynn MReddy Uma MFeghali Maisa NChung JudithHaas David MKua Kok LimLiu Nianjun - - Source: PubMed
Publication date: 2026/02/13
Liu RanMurusuri Aysha BakariHuang SiyiDai ZheJiang WeiTang Jun - Inflammatory arthritis (IA), including rheumatoid arthritis (RA), psoriatic arthritis (PsA) and gout, shares systemic inflammatory features indexed by C-reactive protein (CRP) and interleukin-6 (IL-6), yet the extent of their common genetic basis remains unclear. - Source: PubMed
Publication date: 2026/09/11
Feng XiaojianPan ZhixianLiu Guoping - Pregnancy induces or represses hepatic drug metabolism. Whether pregnancy affects hepatic drug transport is unexplored. We previously showed that a cocktail of pregnancy-related hormones induces mRNA expression and activity of sodium/taurocholate cotransporting polypeptide (NTCP), organic anion transporter 2 (OAT2), and organic cation transporter 1 (OCT1, mRNA only) in differentiated HepaRG cells. Here, using HepaRG cells, we identified cortisol as the hormone primarily responsible for this induction and explored the underlying mechanisms. CRISPR-CRISPR-associated protein 9-mediated knockdown studies in HepaRG cells showed that the glucocorticoid receptor (GR) is the primary mediator of this response. GR knockdown markedly attenuated cortisol-induced NTCP, OAT2, and OCT1 mRNA expression and activity. Cortisol also induced the mRNA expression of regulatory factors, including pregnane X receptor, constitutive androstane receptor, and hepatocyte nuclear factor (HNF) 4 alpha (HNF4α). HNF4α knockdown selectively attenuated OAT2 and OCT1 induction, whereas HNF1α knockdown enhanced NTCP induction, attenuated OCT1 induction, and reduced basal organic anion transporting polypeptide 1B1 expression. In contrast, knockdown of constitutive androstane receptor or pregnane X receptor did not significantly alter cortisol-mediated transporter regulation. These data identify cortisol as the principal pregnancy-related hormone driving regulation of hepatic OAT2, NTCP, and OCT1 in HepaRG cells and indicate that this response is mediated primarily by GR, with selective downstream contributions from HNF4α and HNF1α. These findings provide mechanistic insights into pregnancy-associated changes in hepatic transporter-mediated drug disposition, including when antenatal corticosteroids are administered to pregnant women to prevent respiratory distress syndrome in their prematurely born infants. SIGNIFICANT STATEMENT: The extent and mechanisms by which pregnancy-related hormones regulate hepatic uptake transporters remain poorly defined. This study identifies cortisol as the principal pregnancy-related hormone driving sodium/taurocholate cotransporting polypeptide, organic anion transporter 2, and organic cation transporter 1 induction in HepaRG cells and shows that this response is mediated primarily through glucocorticoid receptor, with transporter-specific contributions from glucocorticoid receptor hepatocyte nuclear factor 4α and hepatocyte nuclear factor 1α. - Source: PubMed
Publication date: 2026/08/03
Sharma SejalTsang Yik PuiUnadkat Jashvant D - Gestational diabetes mellitus (GDM) is linked to poor infant metabolic outcomes, potentially via altered human milk (HM) hormones and microRNAs. Since their specific roles remain unclear, this study synthesizes current evidence on HM adipose tissue-derived hormones (particularly adiponectin, leptin, and resistin) and microRNA modifications during gestational diabetes. Firstly, a systematic review following PRISMA 2020 guidelines was conducted (PROSPERO: CRD42024612813). Searches in major databases identified studies comparing HM adiponectin, leptin, or resistin concentrations and/or miRNA profiles between GDM and normoglycemic mothers. Secondly, bioinformatics analysis using miRWalk 3.0, functional enrichment, and network topology mapping examined miRNA interactions with , and genes. Twelve studies were included. Adiponectin showed the most consistent GDM-associated reductions, though findings were context-dependent. Leptin was primarily associated with maternal adiposity rather than GDM status. Resistin evidence was insufficient. Three miRNA studies revealed stage-dependent dysregulation in GDM, with , and linked to infant growth outcomes during the first 6 months. Bioinformatics identified and as targeting all three adipokine genes, with enrichment in glucose homeostasis and insulin resistance pathways. Network analysis highlighted , and as central nodes. GDM is associated with selective alterations in HM adipokines and miRNAs, with adiponectin and specific miRNAs showing the strongest signals. These findings support a conceptual model where GDM shapes HM's molecular composition through interacting endocrine and posttranscriptional mechanisms, potentially influencing infant metabolic programming. Larger longitudinal studies are needed to validate these observations and determine clinical relevance. - Source: PubMed
Publication date: 2026/08/31
Zhang ZhijunDavoudi MaryamGhafourian AmirrezaDehghan ParmidaAhmadi MojdeAyyoubzadeh Seyed MohammadMiao XiaoleiChoobineh HamidAfrisham Reza