Ask about this productRelated genes to: Fank1 antibody
- Gene:
- FANK1 NIH gene
- Name:
- fibronectin type III and ankyrin repeat domains 1
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 10q26.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-21
- Date modifiied:
- 2018-06-04
Related products to: Fank1 antibody
Related articles to: Fank1 antibody
- Kawasaki disease (KD) is a diffuse vasculitis in children. Response to high dose intravenous gamma globulin (IVIG), the primary treatment, varies according to genetic background. We sought to identify genetic loci, which associate with treatment response using whole genome sequencing (WGS). - Source: PubMed
Publication date: 2024/01/08
Shrestha SadeepWiener Howard WKajimoto HidemiSrinivasasainagendra VinodhLedee DolenaChowdhury SabrinaCui JinhongChen Jake YBeckley Mikayla APadilla Luz ADahdah NagibTiwari Hemant KPortman Michael A - Previous studies have underlined the genetic susceptibility in the pathogenesis of palindromic rheumatism (PR), but the known PR loci only partially explain the disease's genetic background. We aimed to genetically identify PR by whole-exome sequencing (WES). - Source: PubMed
Publication date: 2023/09/20
Zheng ChenxiangWang FanSun YueZhou ZhuochaoYou YijunHe DongyiZhu XiaoxiaJiang LindiLu CuiWu LijunWang HongzhiMei HanyingZeng TingZheng HuiTeng JialingLiu HongleiCheng XiaobingSu YutongShi HuiHu QiongyiJian XuemingFahira AamirYang QiangzhenWang KeWen YanqinWang ZhuoHuang JinyanYang ChengdeShi YongyongYe Junna - A cell-free DNA (cfDNA) assay would be a promising approach to early cancer diagnosis, especially for patients with dense tissues. Consistent cfDNA signatures have been observed for many carcinogens. Recently, investigations of cfDNA as a reliable early detection bioassay have presented a powerful opportunity for detecting dense tissue screening complications early. We performed a prospective study to evaluate the potential of characterizing cfDNA as a central element in the early detection of dense tissue breast cancer (BC). Plasma samples were collected from 32 consenting subjects with dense tissue and positive mammograms, 20 with positive biopsies and 12 with negative biopsies. After screening and before biopsy, cfDNA was extracted, and whole-genome next-generation sequencing (NGS) was performed on all samples. Copy number alteration (CNA) and single nucleotide polymorphism (SNP)/insertion/deletion (Indel) analyses were performed to characterize cfDNA. In the positive-positive subjects (cases), a total of 5 CNAs overlapped with 5 previously reported BC-related oncogenes (KSR2, MAP2K4, MSI2, CANT1 and MSI2). In addition, 1 SNP was detected in KMT2C, a BC oncogene, and 9 others were detected in or near 10 genes (SERAC1, DAGLB, MACF1, NVL, FBXW4, FANK1, KCTD4, CAVIN1; ATP6V0A1 and ZBTB20-AS1) previously associated with non-BC cancers. For the positive-negative subjects (screening), 3 CNAs were detected in BC genes (ACVR2A, CUL3 and PIK3R1), and 5 SNPs were identified in 6 non-BC cancer genes (SNIP1, TBC1D10B, PANK1, PRKCA and RUNX2; SUPT3H). This study presents evidence of the potential of using cfDNA somatic variants as dense tissue BC biomarkers from a noninvasive liquid bioassay for early cancer detection. - Source: PubMed
Publication date: 2022/05/19
Barbirou MouadhMiller Amanda AGafni ErikMezlini AmelZidi AsmaBoley NathanTonellato Peter J - Pancreatic ductal adenocarcinoma (PDAC) is most aggressive among all gastrointestinal tumors. The complex intra-tumor heterogeneity and special tumor microenvironment in PDAC bring great challenges for developing effective treatment strategies. We aimed to delineate dynamic changes of tumor microenvironment components during PDAC malignant progression utilizing single-cell RNA sequencing. - Source: PubMed
Publication date: 2021/04/02
Chen KaiWang QiLi MingzheGuo HuahuLiu WeikangWang FengTian XiaodongYang Yinmo - YY1-associated factor 2 (YAF2) was frequently reported to modulate target gene transcription through both epigenetic and non-epigenetic means. However, other mechanisms were also utilized by YAF2 to carry out its biological functions. Here, we demonstrated that YAF2 from human tumor and non-tumor cells were mainly expressed as Serine 167 phosphorylated form. Further studies showed that the phosphorylated YAF2 up-regulated while its knockdown by specific siRNAs reduced fibronectin type III and ankyrin repeat domains 1 (FANK1) protein level. Mechanistic exploration disclosed that phosphorylated YAF2 inhibit proteasomal degradation of polyubiquitinated FANK1, leading to its increased stability. We then validated their interaction, and displayed that the FN3 domain of FANK1 binds to amino-terminal of YAF2. Functional studies showed that phosphorylated YAF2 inhibits tumor cell apoptosis in a FANK1-dependent manner. Taken together, our current findings demonstrated that phosphorylated YAF2 exhibits anti-apoptotic activity through targeting FANK1 expression in human tumor cells. - Source: PubMed
Publication date: 2021/03/27
Zhang ShiqiangZhang XuanGuan XinMa XiaoliChen HongHuang BingrenChen Deng