Ask about this productRelated genes to: ASCL4 antibody
- Gene:
- ASCL4 NIH gene
- Name:
- achaete-scute family bHLH transcription factor 4
- Previous symbol:
- -
- Synonyms:
- HASH4, bHLHa44
- Chromosome:
- 12q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-05-21
- Date modifiied:
- 2016-10-05
Related products to: ASCL4 antibody
Related articles to: ASCL4 antibody
- Xuebijing (XBJ) has demonstrated efficacy in alleviating clinical symptoms in sepsis patients; however, its underlying mechanism requires further investigation. - Source: PubMed
Publication date: 2026/04/23
Meng XiaoyanYan XinmingKan ChenLi HaiquanHan DaheGuo YiXue PengJiang Yuxin - To explore whether Soufeng Yuchuan (, SFYC) formula alleviates asthma by promoting ferroptosis of airway epithelial cells. - Source: PubMed
Mumu WeiXiaoyu YanYujing ZhangXinxin ZhangYongbin Yan - : Testicular toxicity is one of the most important chemotherapeutic adverse effects of Cisplatin (Cisp), which restricts its use and effectiveness. This study investigated the preventive effects of L. extract on Cisp-induced testicular injury in rats. : Forty adult albino male rats were allocated into four groups: control, L. extract, Cisp, and co-treated ( L. extract + Cisp). Sperm motility and count, serum reproductive hormones, oxidative/antioxidant biomarkers, pro-inflammatory cytokines, ferroptosis biomarkers, and gene expression profiles were evaluated. : Cisp administration markedly impaired reproductive performance, as evidenced by significant declines in serum FSH, LH, testosterone, and sperm motility and count. Cisp also induced oxidative stress by elevating MDA, GSSG, GPx, and 8-OHdG, while reducing SOD, Catalase, NRF2, and Ho-1 along with total and reduced GSH levels. Moreover, it triggered strong inflammatory responses and ferroptosis activation, with notable up-regulation of NFκB, TNF-α, IL-1β, ferritin, and cathepsin. Gene expression analysis revealed down-regulation of ARNTL, PI3K, and miR-125b and up-regulation of ASCL4, GSK3B, and COX2 following Cisp exposure. Conversely, co-treatment with L. extract significantly ameliorated these alterations, restoring sperm quality, hormone balance, antioxidant defenses, and modulating inflammatory, ferroptosis, and genetic responses toward normalcy in addition to restoring testicular and epididymal histoarchitecture without any significant effect in NRF2 and ARNTL expression. Additionally, co-treated groups with L. extract showed a significant decline in NF-kB p65 and increased PCNA testicular immunoreactivity with a substantial down-regulation in NF-kB p65 and PCNA epididymal immunoreactivity. L. extract alone did not affect any studied parameters as compared to the control group. : These findings suggested that L. extract has a significant protective effect against Cisp-related testicular injury through antioxidative, anti-inflammatory, and anti-ferroptotic mechanisms. - Source: PubMed
Publication date: 2026/01/20
Mohammed Salman A ASaad Hebatallah MEsmail Kariman AEliwa DuaaRohiem Aya HAwad Amal AEl-Adawy Samar AAmer Shimaa SAbdelhiee Ehab Y - While circuit formation is generally thought to be absent in the adult brain, there is evidence that the adult brain retains a considerable capacity for neuronal wiring. Among other findings, molecular programming by basic helix-loop-helix (bHLH) proteins can reactivate axon growth in adult neurons, allowing the investigation of the mechanisms and potential of adult brain rewiring. Here, we analyzed proteomic and transcriptomic changes during Id2-induced (a bHLH transcriptional regulator) and Ascl4-induced (a bHLH transcription factor) feedback and feedforward wiring in the hippocampus of adult male and female mice. We find that Id2 and Ascl4 share a molecular cascade through the transcription factor Stat1 and coregulate a set of proteins that may constitute a core program for adult wiring. Unexpectedly, we also identify shared molecular changes that do not originate directly from the programmed neurons, but from endothelial cells and microglia. Taken together, our results suggest that adult brain wiring is regulated by specific molecular programs and dynamic interactions between the wiring neurons and the circuit environment. - Source: PubMed
Publication date: 2026/02/18
Seng CharlotteTamás BálintKaur RashmitLuo WenshuFöldy Csaba - Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are associated with anti-inflammatory effects. However, few studies have investigated their molecular effects in the kidney. We have previously shown that intrauterine growth restriction (IUGR) can lead to aggravation of mesangioproliferative glomerulonephritis and that n-3 PUFAs can attenuate long-term effects of IUGR by reversing pro-inflammatory molecular signatures in kidney cortex. - Source: PubMed
Publication date: 2026/01/05
Saschin LeonKowalewski AnnaFink GregorVoggel JennyWohlfarth MariaQuell LeaDötsch JörgAlejandre Alcázar Miguel ANüsken Kai-DietrichNüsken Eva