Ask about this productRelated genes to: ZNF468 antibody
- Gene:
- ZNF468 NIH gene
- Name:
- zinc finger protein 468
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19q13.41
- Locus Type:
- gene with protein product
- Date approved:
- 2006-08-11
- Date modifiied:
- 2014-11-19
Related products to: ZNF468 antibody
Related articles to: ZNF468 antibody
- Despite significant evidence of a genetic contribution to strabismus, precise genetic mechanisms have not been identified. There are distinct population differences in the prevalence of strabismus and its subtypes. This study aimed to explore the genetic contributions to strabismus in different ancestral groups. - Source: PubMed
Publication date: 2025/07/01
Lee Kyoung A ViolaTesdahl CoreyAboobakar Inas FJain AshishMartinez Sanchez MayraJin KimberlyOke IsdinWhitman Mary C - While prior research linked ZNF468 to radioresistance in oesophageal squamous cell carcinoma (ESCC), its broader role in ESCC progression remained unclear. This study elucidates these functions and underlying mechanisms. Immunohistochemistry on clinical ESCC tissues demonstrated ZNF468 upregulation, which correlated with unfavourable patient outcomes and increased Aurora A expression. In vitro experiments, including assessments of proliferation, apoptosis, migration and invasion, revealed that ZNF468 overexpression enhanced these oncogenic phenotypes in ESCC cells, while its knockdown produced inhibitory effects. These findings were corroborated in vivo using subcutaneous tumour and lung metastasis models. Mechanistically, ZNF468 was found to upregulate AURKA expression, subsequently activating the PI3K/AKT signalling pathway, thereby promoting cell proliferation and epithelial-mesenchymal transition (EMT). Importantly, pharmacological inhibition of AURKA or the PI3K/AKT pathway significantly attenuated the pro-tumorigenic effects driven by ZNF468. Furthermore, AKT was shown to augment ZNF468 protein stability and transcriptional activity, establishing a ZNF468/AURKA/PI3K/AKT positive feedback loop. In conclusion, this study identifies a critical positive feedback mechanism involving ZNF468/AURKA/PI3K/AKT that significantly promotes ESCC progression, underscoring ZNF468 as a potential therapeutic target. - Source: PubMed
Bai GeWang LeiZhang LiEli Mayinur - ZNF468 is a zinc finger protein that plays a key role in the occurrence and development of tumors. However, no studies have demonstrated whether ZNF468 is involved in the progression of esophageal squamous cell carcinoma (ESCC). - Source: PubMed
Publication date: 2024/10/31
Ye LuxiaPan YixiaoBao JiaqianGuo YiqingLu LingxiaoZheng Jingmin - Dysfunctional lymphangiogenesis is pivotal for various pathological processes including tumor lymph node metastasis which is a crucial cause of therapeutic failure for ESCC. In this study, we aim to elucidate the molecular mechanisms and clinical relevance of Zinc-finger protein ZNF468 in lymphangiogenesis and lymphatic metastasis in ESCC. - Source: PubMed
Publication date: 2024/08/14
Zhu JinrongQiu XiangyuJin XinNie XiaoyaOu ShengmingWu GeyanShen JianfeiZhang Rongxin - Because of the progress on the diagnosis and treatment for patients with breast cancer (BC), the overall survival of the patients has been improved. However, a number of BC patients cannot benefit from the existing therapeutic strategies as the essential molecular events triggering the development of BC are not well understood. Previous studies have shown that abnormal expression of zinc finger proteins is involved in the development of various malignancies, whereas it remains largely unclear on their significance during the progression of BC. In this study, we aimed to explore the clinical relevance, cellular function and underlying mechanisms of zinc finger protein 468 (ZNF468) in BC. - Source: PubMed
Publication date: 2024/03/01
Jia ZhaoyangWang FengLi GongzhuoJiang PingLeng YuanxiuKe LongzhuLuo LiGao Wei