Ask about this productRelated genes to: ZNF385B antibody
- Gene:
- ZNF385B NIH gene
- Name:
- zinc finger protein 385B
- Previous symbol:
- ZNF533
- Synonyms:
- FLJ25270
- Chromosome:
- 2q31.2-q31.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-05
- Date modifiied:
- 2018-02-13
Related products to: ZNF385B antibody
Related articles to: ZNF385B antibody
- Although ZNF385B, a member of the zinc finger protein family, plays important roles in various physiological processes, its involvement in cancer remains poorly understood. In this study, we systematically investigated the expression patterns, prognostic value, and molecular characteristics of ZNF385B across multiple cancer types using data from The Cancer Genome Atlas (TCGA), with a particular focus on ovarian cancer. To support the bioinformatics findings, a series of functional experiments were performed to explore the biological role of ZNF385B. Our analysis revealed that ZNF385B exhibits differential expression across various cancers and is associated with either favorable or unfavorable prognosis depending on the tumor type. Functional enrichment analyses suggest that ZNF385B is involved in critical cellular processes, such as transcriptional regulation, protein modification, and cellular localization. Separately, ZNF385B expression shows a significant correlation with immune cell infiltration in multiple tumor types, implying a potential role in tumor immune modulation and cancer prognosis. These findings provide novel insights into the biological functions of ZNF385B and highlight its potential as a prognostic and immunological biomarker in ovarian and other cancers. - Source: PubMed
Publication date: 2025/08/04
Yu HangCheng WeiHuang AoshuangFeng JingZi Dan - Hu sheep is an indigenous breed from the Taihu Lake Plain in China, known for its high fertility. Although Hu sheep belong to the Mongolian group, their demographic history and genetic architecture remain inconclusive. Here, we analyze 697 sheep genomes from representatives of Mongolian sheep breeds. Our study suggests that the ancestral Hu sheep first separated from the Mongolian group approximately 3000 years ago. As Hu sheep migrated from the north and flourished in the Taihu Lake Plain around 1000 years ago, they developed a unique genetic foundation and phenotypic characteristics, which are evident in the genomic footprints of selective sweeps and structural variation landscape. Genes associated with reproductive traits (BMPR1B and TDRD10) and horn phenotype (RXFP2) exhibit notable selective sweeps in the genome of Hu sheep. A genome-wide association analysis reveals that structural variations at LOC101110773, MAST2, and ZNF385B may significantly impact polledness, teat number, and early growth in Hu sheep, respectively. Our study offers insights into the evolutionary history of Hu sheep and may serve as a valuable genetic resource to enhance the understanding of complex traits in Hu sheep. - Source: PubMed
Publication date: 2024/12/04
Chen KaiyuZhang YuelangPan YizheXiang XinPeng ChenHe JiayiHuang GuiqingWang ZhengguangZhao Pengju - Goats belong to a group of animals called small ruminants and are critical sources of livelihood for rural people. Genomic sequencing can provide information ranging from basic knowledge about goat diversity and evolutionary processes that shape genomes to functional information about genes/genomic regions. In this study, we exploited a whole-genome sequencing data set to analyze the genetic diversity, population structure and selection signatures of 44 individuals belonging to 5 Ethiopian goat populations: 12 Aberegalle (AB), 5 Afar (AF), 11 Begait (BG), 12 Central highlands (CH) and 5 Meafure (MR) goats. Our results revealed the highest genetic diversity in the BG goat population compared to the other goat populations. The pairwise genetic differentiation (F) among the populations varied and ranged from 0.011 to 0.182, with the closest pairwise value (0.003) observed between the AB and CH goats and a distant correlation ( = 0.182) between the BG and AB goats, indicating low to moderate genetic differentiation. Phylogenetic tree, ADMIXTURE and principal component analyses revealed a classification of the five Ethiopian goat breeds in accordance with their geographic distribution. We also found three top genomic regions that were detected under selection on chromosomes 2, 5 and 13. Moreover, this study identified different candidate genes related to milk characteristics (GLYCAM1 and ), carcass (, , , , and ) and adaptive and immune response genes , , , , and ). In conclusion, this information could be helpful for understanding the genetic diversity and population structure and selection scanning of these important indigenous goats for future genetic improvement and/or as an intervention mechanism. - Source: PubMed
Publication date: 2024/01/18
Gebreselase Haile BerihulayNigussie HailemichaelWang ChangfaLuo Chenglong - ZNF385B, a zinc finger protein, has been known as a potential biomarker in some neurological and hematological studies recently. Although numerous studies have demonstrated the potential function of zinc finger proteins in tumor progression, the effects of ZNF385B in breast cancer (BC) are less studied. - Source: PubMed
Publication date: 2021/02/03
Yan NingLiu CongTian FangWang LingWang YiminYang ZhaoyingJiao YanHe Miao - Age-related macular degeneration (AMD) is the leading cause of irreversible blindness among the elderly population. To accelerate the understanding of the genetics of AMD, we conducted a meta-analysis of genome-wide association studies (GWAS) combining data from the International AMD Genomics Consortium AMD-2016 GWAS (16,144 advanced AMD cases and 17,832 controls), AMD-2013 GWAS (17,181 cases and 60,074 controls), and new data on 4017 AMD cases and 14,984 controls from Genetic Epidemiology Research on Aging study. We identified 12 novel AMD loci near or within C4BPA-CD55, ZNF385B, ZBTB38, NFKB1, LINC00461, ADAM19, CPN1, ACSL5, CSK, RLBP1, CLUL1, and LBP. We then replicated the associations of the novel loci in independent cohorts, UK Biobank (5860 cases and 126,726 controls) and FinnGen (1266 cases and 47,560 control). In general, the concordance in effect sizes was very high (correlation in effect size estimates 0.89), 11 of 12 novel loci were in the expected direction, 5 were associated with AMD at a nominal significance level, and rs3825991 (near gene RLBP1) after Bonferroni correction. We identified an additional 21 novel genes using a gene-based test. Most of the novel genes are expressed in retinal tissue and could be involved in the pathogenesis of AMD (i.e., complement, inflammation, and lipid pathways). These findings enhance our understanding of the genetic architecture of AMD and shed light on the biological process underlying AMD pathogenesis. - Source: PubMed
Publication date: 2020/04/10
Han XikunGharahkhani PuyaMitchell PaulLiew GeraldHewitt Alex WMacGregor Stuart