Ask about this productRelated genes to: ZNF565 antibody
- Gene:
- ZNF565 NIH gene
- Name:
- zinc finger protein 565
- Previous symbol:
- -
- Synonyms:
- FLJ36991
- Chromosome:
- 19q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-15
- Date modifiied:
- 2014-11-19
Related products to: ZNF565 antibody
Related articles to: ZNF565 antibody
- Activating mutations involving the PI3K pathway occur frequently in human cancers. However, PI3K inhibitors primarily induce cell cycle arrest, leaving a significant reservoir of tumor cells that may acquire or exhibit resistance. We searched for genes that are required for the survival of PI3K mutant cancer cells in the presence of PI3K inhibition by conducting a genome scale shRNA-based apoptosis screen in a mutant human breast cancer cell. We identified 5 genes () whose suppression induced cell death upon PI3K inhibition. We showed that small molecule inhibitors of the PIM2 and ZAK kinases synergize with PI3K inhibition. In addition, using a microscale implementable device to deliver either siRNAs or small molecule inhibitors in vivo, we showed that suppressing these 5 genes with PI3K inhibition induced tumor regression. These observations identify targets whose inhibition synergizes with PI3K inhibitors and nominate potential combination therapies involving PI3K inhibition. - Source: PubMed
Publication date: 2017/05/31
Zwang YaaraJonas OliverChen CasandraRinne Mikael LDoench John GPiccioni FedericaTan LiHuang Hai-TsangWang JinhuaHam Young JinO'Connell JoyceBhola PatrickDoshi MihirWhitman MatthewCima MichaelLetai AnthonyRoot David ELanger Robert SGray NathanaelHahn William C