Ask about this productRelated genes to: ZNF700 antibody
- Gene:
- ZNF700 NIH gene
- Name:
- zinc finger protein 700
- Previous symbol:
- -
- Synonyms:
- DKFZp434I1610
- Chromosome:
- 19p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-08-11
- Date modifiied:
- 2014-11-18
Related products to: ZNF700 antibody
Related articles to: ZNF700 antibody
- The potential biomarkers for Parkinson's Disease (PD) in blood circulating cell-free DNA (cfDNA) have been infrequently explored. This study aims to identify specific methylation markers in blood cfDNA that could aid in the diagnosis of PD. - Source: PubMed
Publication date: 2025/06/10
Zhu AiqinWang FenglinMeng JieLi XiaotaoLiang HongxiuLiang YuhuaSong Lele - In this study, effective antigens of mRNA vaccine were excavated from the perspective of ICD, and ICD subtypes of PRAD were further distinguished to establish an ICD landscape, thereby determining suitable vaccine recipients. - Source: PubMed
Publication date: 2024/09/02
Yu GuopengLin YuanshengWang JianqingZhou LinLu YingyingFei XiangGu XinSong ShangqingWang JiangyiLiu YushanYang QingZhan MingSeo Seung-YongXu Bin - As the most common arrhythmia, atrial fibrillation (AF) is associated with a significantly increased risk of stroke, which causes high disability and mortality. To date, the underlying mechanism of stroke occurring after AF remains unclear. Herein, we studied hub genes and regulatory pathways involved in AF and secondary stroke and aimed to reveal biomarkers and therapeutic targets of AF-related stroke. - Source: PubMed
Publication date: 2023/03/23
Huang KaiFan XiJiang YuwenJin ShengHuang JiechunPang LiewenWang YiqingWu YumingSun Xiaotian - Down syndrome (DS) is characterized by neurodevelopmental abnormalities caused by partial or complete trisomy of human chromosome 21 (T21). Analysis of Down syndrome brain specimens has shown global epigenetic and transcriptional changes but their interplay during early neurogenesis remains largely unknown. We differentiated induced pluripotent stem cells (iPSCs) established from two DS patients with complete T21 and matched euploid donors into two distinct neural stages corresponding to early- and mid-gestational ages. - Source: PubMed
Publication date: 2020/01/08
Laan LooraKlar JoakimSobol MariaHoeber JanShahsavani MansourehKele MalinFatima AmbrinZakaria MuhammadAnnerén GöranFalk AnnaSchuster JensDahl Niklas - Colorectal cancer is one of the most common cancers worldwide with almost 700,000 deaths every year. Detection of colorectal cancer at an early stage significantly improves patient survival. Cancer-specific autoantibodies found in sera of cancer patients can be used for pre-symptomatic detection of the disease. In this study we assess the zinc finger proteins ZNF346, ZNF638, ZNF700 and ZNF768 as capture antigens for the detection of autoantibodies in colorectal cancer. Sera from 96 patients with colorectal cancer and 35 control patients with no evidence of cancer on colonoscopy were analysed for the presence of ZNF-specific autoantibodies using an indirect ELISA. Autoantibodies to individual ZNF proteins were detected in 10-20% of colorectal cancer patients and in 0-5.7% of controls. A panel of all four ZNF proteins resulted in an assay specificity of 91.4% and sensitivity of 41.7% for the detection of cancer patients in a cohort of non-cancer controls and colorectal cancer patients. Clinicopathological and survival analysis revealed that ZNF autoantibodies were independent of disease stage and did not correlate with disease outcome. Since ZNF autoantibodies were shared between patients and corresponding ZNF proteins showed similarities in their zinc finger motifs, we performed an in silico epitope sequence analysis. Zinc finger proteins ZNF700 and ZNF768 showed the highest sequence similarity with a bl2seq score of 262 (E-value 1E-81) and their classical C2H2 ZNF motifs were identified as potential epitopes contributing to their elevated immunogenic potential. Our findings show an enhanced and specific immunogenicity to zinc finger proteins, thereby providing a multiplexed autoantibody assay for minimally invasive detection of colorectal cancer. - Source: PubMed
Publication date: 2015/04/13
O'Reilly Julie-AnnFitzgerald JennyFitzgerald SeánKenny DermotKay Elaine WO'Kennedy RichardKijanka Gregor S