Ask about this productRelated genes to: ZFP90 antibody
- Gene:
- ZFP90 NIH gene
- Name:
- ZFP90 zinc finger protein
- Previous symbol:
- -
- Synonyms:
- KIAA1954, NK10, ZNF756
- Chromosome:
- 16q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-11-07
- Date modifiied:
- 2018-11-22
Related products to: ZFP90 antibody
Related articles to: ZFP90 antibody
- Atopic dermatitis (AD) occurs across all ages but presents distinct clinical and immunologic features between children, adults, and older adults. The molecular programs underlying these age-specific immune differences remain poorly understood. - Source: PubMed
Publication date: 2025/11/25
Baldonado Gian Carlo LKumar SugandhJin JoyFang XiaohuiIldardashty AlexanderBraun MitchellNeuhaus Isaac MMathes ErinBhutani TinaLiao Wilson - Telomeric repeat binding factor 2 (TERF2), a key component of the Shelterin complex, is crucial for maintaining telomere integrity and genome stability. While the involvement of TERF2 in tumorigenesis and progression has been documented, comprehensive pan-cancer analyses of TERF2 across different malignancies remain scarce. - Source: PubMed
Publication date: 2025/02/24
Ma QiangXu WenGuo Xiaolan - Forkhead box protein P3 (FOXP3) is known to orchestrate the development and maintenance of T regulatory cells, a cell population specialized in immune suppression and peripheral immune tolerance. FOXP3 activity is fine-tuned through its interaction with several protein-binding partners. By using IntAct database, we retrieved three physical binary interactors: E3 ubiquitin-protein ligase CHIP, Zfp-90, and nuclear receptor ROR-α. Coevolution clusters between FOXP3 and its interactors were identified with the use of iBIS2 algorithm, the iterative version of BIS/BIS2. Most of the coevolving pairs came from some species of monotremes and marsupials, as well as from a group of bats, thus suggesting that protein interactions of FOXP3 with its partners may be changed and/or modulated during mammalian speciation. Furthermore, our analysis would suggest the occurrence of a determinant role of FOXP3 in suppressing pregnancy alloreactions in placental mammals. Similarly, FOXP3, through its interaction with different protein interaction mechanisms, would explain the unique control of inflammatory response to infections in bats. By identifying several inter-protein clusters between the different protein pairs, our findings may provide a guide for new therapeutic approaches to modulate T regulatory suppression and/or enhance immune tolerance. - Source: PubMed
Publication date: 2023/03/25
D'Amico FabioSkarmoutsou EvangeliaLibra Massimo - Our study discussed the role of Zfp90 in ovarian cancer (OC) cell lines' sensitivity to cisplatin. We used two OC cell lines, SK-OV-3 and ES-2, to evaluate their role in cisplatin sensitization. The protein levels of p-Akt, ERK, caspase 3, Bcl-2, Bax, E-cadherin, MMP-2, MMP-9 and other drug resistance-related molecules, including Nrf2/HO-1, were discovered in the SK-OV-3 and ES-2 cells. We also used a human ovarian surface epithelial cell to compare the effect of Zfp90. Our outcomes indicated that cisplatin treatment generates reactive oxygen species (ROS) that modulate apoptotic protein expression. The anti-oxidative signal was also stimulated, which could hinder cell migration. The intervention of Zfp90 could greatly improve the apoptosis pathway and block the migrative pathway to regulate the cisplatin sensitivity in the OC cells. This study implies that the loss of function of Zfp90 might promote cisplatin sensitization in OC cells via regulating the Nrf2/HO-1 pathway to enhance cell apoptosis and inhibit the migrative effect in both SK-OV-3 and ES-2 cells. - Source: PubMed
Publication date: 2023/03/03
Wu Ching-HuFeng Chien-WeiWang Chiu-LinWen Zhi-HongLong Cheng-YuTang Feng-Hsiang - Genome, transcriptome and methylome-wide association studies have identified single-nucleotide polymorphisms (SNPs) or genes at 258 loci associated with colorectal cancer (CRC) risk. We studied the relationship between these and patient outcome. - Source: PubMed
Publication date: 2023/06/22
Wills ChristopherHouseman AmyWatts KatieMaughan Timothy SFisher DavidHoulston Richard SWest Hannah DEscott-Price ValentinaCheadle Jeremy P