Ask about this productRelated genes to: TCEAL2 antibody
- Gene:
- TCEAL2 NIH gene
- Name:
- transcription elongation factor A like 2
- Previous symbol:
- -
- Synonyms:
- my048, MY0876G05, WEX1
- Chromosome:
- Xq22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-08-16
- Date modifiied:
- 2016-10-05
Related products to: TCEAL2 antibody
Related articles to: TCEAL2 antibody
- Deoxynivalenol (DON) is one of the most prevalent mycotoxins found in livestock feed and is known to impair reproductive physiology and oocyte quality. Melatonin (MEL), a potent antioxidant, has been reported to mitigate DON-induced cytotoxicity during in vitro maturation (IVM) of porcine oocytes and cumulus cells. This study aimed to evaluate the impact of DON and MEL supplementation during IVM on oocyte developmental competence and transcriptomic profiles. Developmental outcomes revealed that exposure to DON (1 μM) significantly reduced oocyte maturation (47.6%), whereas co-treatment with DON (1 μM) plus MEL (1 μM) markedly improved the maturation rate (74.4%). To investigate underlying molecular changes, next-generation sequencing (NGS) was performed, followed by quantitative PCR (qPCR) validation of 14 candidate genes. In cumulus cells, MEL supplementation significantly upregulated ATP5F1E, TCEAL2, and RNase P compared to DON treatment alone. In oocytes, MEL restored the expression of mitochondrial and stress-related genes, including NDUFB6, ATP8, and SEC61A2, while reducing the expression of COX15, ACSL4, CPEB2, and MAP7 genes associated with mitochondrial clearance, ferroptosis, and cytoskeletal stress. These expressions were consistent between NGS and qPCR analyses. Collectively, the results suggest that MEL supplementation during IVM alleviates DON-induced cytotoxicity by enhancing mitochondrial function, reducing oxidative stress, and normalizing gene expression in porcine oocytes and cumulus cells. Moreover, these findings support MEL's potential as a protective agent in mycotoxin-contaminated reproductive systems. - Source: PubMed
Publication date: 2026/05/02
Shen Perng-ChihChen Yan-PingBallantyne RolissaChiang Zhong-FengLee Yen-HuaLee Jai-WeiYu Chi - Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) are major gynecological malignancies, causing significant cancer-related deaths in women. Current treatments yield poor outcomes, with a 5-year survival rate of only 17%. Identifying new biomarkers and therapeutic targets is crucial for improving prognosis and guiding personalized treatments. - Source: PubMed
Li JinyuanYe ZhenGan YuhongLi DongbingChen Yibiao - The genomic fusions of the anaplastic lymphoma kinase () gene have been widely recognized as effective therapeutic targets for non-small cell lung carcinoma (NSCLC). The Second Xiangya Hospital of Central South University has treated 2 NSCLC patients with 2 distinct novel gene fusions. Case 1 was a 55-year-old male with a solid nodule located in the right hilar lobe on enhanced CT scan. Case 2 was a 47-year-old female with enhanced CT showing involvement of the left upper lobe of lung. Histopathological examination of tumor tissues confirmed lung adenocarcinoma in both cases. Immunohistochemical (IHC) staining demonstrated positivity for thyroid transcription factor-1 (TTF-1) and ALK-D5F3 in tumor cells, while negativity for P40. The next-generation sequencing (NGS) tests identified a - (Exon22:Exon20) fusion variant in case 1 and a - (Exon3:Exon19) fusion variant in case 2. The - fusion was further confirmed by amplification refractory mutation system (ARMS)-PCR at the mRNA level. Both patients were treated with oral alectinib at a dosage of 600 mg twice daily. The tumors in both patients were significantly decreased after alectinib treatment, achieving partial response. At the time of submission, there was an absence of disease progression and the progression-free survival (PFS) had surpassed 1 year. It offered compelling evidences that the individuals with NSCLC and harboring either a - (Exon22:Exon20) fusion or a - (Exon3:Exon19) fusion, experience favorable therapeutic outcomes through the administration of alectinib. This study expands the known fusion variants database and supports the precision treatment of NSCLC using tyrosine kinase inhibitors (TKIs). - Source: PubMed
Liang QingchunLi NameiLi Xiaohong - The molecular mechanism of chemotherapy resistance in breast cancer is not well understood. The identification of genes associated with chemoresistance is critical for a better understanding of the molecular processes driving resistance. - Source: PubMed
Publication date: 2023/06/15
Miri AliGharechahi JavadSamiei Mosleh ImanSharifi KazemJajarmi Vahid - Colon adenocarcinoma (COAD) is the primary factor responsible for cancer-related mortalities in western countries, and its development and progression are affected by altered sphingolipid metabolism. The current study aimed at investigating the effects of sphingolipid metabolism-related (SLP) genes on multiple human cancers, especially on COAD. We obtained 1287 SLP genes from the GeneCard and MsigDb databases along with the public transcriptome data and the related clinical information. The univariate Cox regression analysis suggested that 26 SLP genes were substantially related to the prognosis of COAD, and a majority of SLP genes served as the risk genes for the tumor, insinuating a potential pathogenic effect of SLP in COAD development. Pan-cancer characterization of SLP genes summarized their expression traits, mutation traits, and methylation levels. Subsequently, we focused on the thorough research of COAD. With the help of unsupervised clustering, 1008 COAD patients were successfully divided into two distinct subtypes (C1 and C2). C1 subtype is characterized by a poor prognosis, activation of SLP pathways, high expression of SLP genes, disordered carcinogenic pathways, and immune microenvironment. Based on the clusters of SLP, we developed and validated a novel prognostic model, consisting of ANO1, C2CD4A, EEF1A2, GRP, HEYL, IGF1, LAMA2, LSAMP, RBP1, and TCEAL2, to quantitatively evaluate the clinical outcomes of COAD. The Kaplain-Meier survival curves and ROC curves highlighted the accuracy of our SLP model in both internal and external cohorts. Compared to normal colon tissues, expression of C2CD4A was detected to be significantly higher in COAD; whereas, expression levels of EEF1A2, IGF1, and TCEAL2 were detected to be significantly lower in COAD. Overall, our research emphasized the pathogenic role of SLP in COAD and found that targeting SLP might help improve the clinical outcomes of COAD. The risk model based on SLP metabolism provided a new horizon for prognosis assessment and customized patient intervention. - Source: PubMed
Publication date: 2022/11/28
Yuan QihangZhang WeizhiShang Weijia