Ask about this productRelated genes to: ZBTB46 antibody
- Gene:
- ZBTB46 NIH gene
- Name:
- zinc finger and BTB domain containing 46
- Previous symbol:
- ZNF340, BTBD4
- Synonyms:
- FLJ13502, RINZF, BZEL
- Chromosome:
- 20q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 2001-07-17
- Date modifiied:
- 2014-11-19
Related products to: ZBTB46 antibody
Related articles to: ZBTB46 antibody
- To elucidate the oncogenic role and molecular pathways associated with long non-coding RNA ZBTB46-AS1 (lncRNA ZBTB46-AS1) in ovarian cancer (OC) progression. - Source: PubMed
Publication date: 2026/02/15
Wang LiyuLiang BaoquanHuang AnquanZhang LuyaoFeng YingWang GuoqiangGuo FenXu Hong - Circular RNAs are emerging regulators of stress responses, yet their roles in endothelial injury that leads to sepsis-related acute kidney injury remain incompletely defined. We hypothesized that the circular RNA ZBTB46 (circZBTB46) confers endothelial protection by engaging ERBB2-AKT signaling. Using a cell-based model in which human umbilical vein endothelial cells were challenged with lipopolysaccharide, we quantified circZBTB46 expression and tested the effects of its forced expression on survival, apoptosis, inflammatory mediators, and redox homeostasis. Cell viability assays and flow cytometry assessed survival and apoptosis. Enzyme-linked immunosorbent assays measured interleukin-6, tumor necrosis factor-α, and interleukin-1β, while reactive oxygen species, malondialdehyde, superoxide dismutase, and catalase were evaluated as indices of oxidative injury and antioxidant capacity. To define the mechanism, we performed transcriptome profiling with gene set enrichment analysis, confirmed pathway proteins by Western blotting, and assessed the necessity using the ERBB2 inhibitor AG-825. Lipopolysaccharide suppressed circZBTB46. CircZBTB46 overexpression increased viability, lowered apoptosis, reduced pro-inflammatory cytokines and reactive oxygen species, decreased malondialdehyde, and raised superoxide dismutase and catalase activities. Transcriptomic and protein analyses supported activation of the ERBB2-AKT axis, and pharmacologic ERBB2 blockade blunted cytoprotection and reversed gains in redox balance. These findings identify circZBTB46 as an endogenous brake on lipopolysaccharide-induced endothelial damage through ERBB2-AKT signaling and nominate circZBTB46 as a mechanistic node and potential therapeutic target for sepsis-related acute kidney injury. - Source: PubMed
Publication date: 2026/02/13
Zhuang Jinkun - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease worldwide, characterized by multiple metabolic disturbances. This complexity poses significant challenges for early diagnosis and effective treatment, highlighting the urgent need for novel biomarkers and therapeutic strategies. Circular RNAs (circRNAs) have attracted attention due to their unique stability and regulatory roles in various diseases, providing new opportunities for MASLD diagnosis and treatment. This study investigated the role of circZBTB46 in MASLD and its underlying molecular mechanism. Liver tissues from three healthy controls, three patients with MASLD, and three patients with metabolic dysfunction-associated steatohepatitis (MASH) were analyzed using RNA sequencing and bioinformatics analysis to identify differentially expressed circRNAs. CircRNA-miRNA interactions were predicted through the circinteractome database and validated by dual-luciferase reporter gene assays and RNA pull-down experiments. mRNA and protein expression were evaluated by qRT-PCR and western blot, while triglyceride and cholesterol levels were measured by ELISA. Lipid deposition was visualized through Oil Red O and BODIPY 493/503 staining. The results showed that circZBTB46, derived from the ZBTB46 gene, was downregulated in patients with MASLD and in experimental models. Overexpression of circZBTB46 significantly reduced hepatic lipid accumulation and triglyceride content. This effect is mediated through the circZBTB46/miRNA-326/FGF1 pathway, in which circZBTB46 directly binds to miRNA-326, functioning as a competitive endogenous RNA (ceRNA) to relieve miRNA-326-mediated suppression of FGF1, thereby alleviating hepatic lipid accumulation. These findings reveal the critical role of circZBTB46 in MASLD and provide valuable insights into its potential as a diagnostic biomarker and therapeutic target for MASLD. - Source: PubMed
Publication date: 2026/01/09
Zeng Qing-MinHu TengyueJiang WeiTeng XiangnanWu DongboTang HongLiu Chang-Hai - Adipose tissue (AT) immune cells regulate metabolic functions in obesity through both inflammatory and non-inflammatory pathways. However, the specific roles and mechanisms of individual AT immune cell types in glycemic control remain poorly understood. - Source: PubMed
Publication date: 2025/10/23
Soedono ShindyVo Dan Hoang NguyetChang JiyeonSharlene SharleneBayona Princess WendyKim SooyoungHong Jun YoungCho Kae Won - Lung cancer is a leading cause of cancer deaths worldwide, underscoring the need for new biomarkers. Circular RNAs (circRNAs) exhibit potential as biomarkers for lung cancer. ZBTB46 is linked to lung cancer prognosis. This study intends to investigate circRNA expression and the role of ZBTB46 in predicting and treating lung cancer. - Source: PubMed
Publication date: 2025/08/07
Wang XifanSong XiaoyanWei HongxuanLi XiaoqingLi HuihuiZhu YanZhu ChuandongChen Fangfang