Ask about this productRelated genes to: ZNHIT1 antibody
- Gene:
- ZNHIT1 NIH gene
- Name:
- zinc finger HIT-type containing 1
- Previous symbol:
- ZNFN4A1
- Synonyms:
- CG1I, H_DJ0747G18.14
- Chromosome:
- 7q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 2003-07-14
- Date modifiied:
- 2016-02-12
Related products to: ZNHIT1 antibody
Related articles to: ZNHIT1 antibody
- Mammalian oogenesis is a precisely orchestrated developmental process, which depends on accurate chromatin remodeling and transcriptional regulation in the absence of DNA replication. The histone variant H2A.Z is required for oogenesis and embryogenesis, yet the chaperone directing its deposition has not been well characterized in mammalian oocytes. Here, we identify Znhit1, a core subunit of the SRCAP chromatin remodeling complex, as the essential factor mediating H2A.Z deposition in oocytes. Oocyte specific depletion of Znhit1 impairs H2A.Z incorporation and leads to severe ovarian phenotype, characterized by follicle loss, homologous chromosome segregation defects and meiotic arrest, which ultimately leads to female infertility. On molecular level, integrated Smart-seq2 and H2A.Z CUT&Tag analyses demonstrate that Znhit1 depletion severely reduces genome-wide H2A.Z deposition, particularly at promoter regions of key meiotic genes such as Aurkb, Tpm3, and Zar1, resulting in transcriptional dysregulation and aberrant meiotic gene expression. Our findings pinpoint Znhit1 as the histone chaperone essential for accurate deposition of histone variant H2A.Z ensuring meiotic progression and oocyte development in mice. - Source: PubMed
Publication date: 2026/05/05
Fan NaGong HongyuWang PeijunBai XueHe XigeChen NaGao JiayingLi HaoranWang LuNaren GerileGao FeiGuo JiaojiaoLiu TieminJiang NingLin XinhuaLi XiheNashun Buhe - Migraine is a neurological disorder, affecting approximately 1.16 billion individuals globally. Zinc finger HIT-type containing 1 (Znhit1), a chromatin remodeler, has exhibited a neuroprotective role. This study aims to investigate the role of Znhit1 in migraine. - Source: PubMed
Publication date: 2025/10/14
Wang XueTang JianhuaHou YiweiSui Changbai - Fatty acid metabolism (FAM) reprogramming is a prominent feature of clear cell renal cell carcinoma (ccRCC). Nevertheless, the effect of FAM reprogramming on the heterogeneity and prognosis of ccRCC individuals remains insufficiently understood. - Source: PubMed
Publication date: 2025/06/05
Wang NingXu ZiyuZhang LinaLu YanfangWang YanliangYan LeiCao HuixiaWang LimengShao Fengmin - Pooled single-cell CRISPR screens have profiled either gene expression or chromatin accessibility but not both modalities. Here we develop MultiPerturb-seq, a high-throughput CRISPR screening platform with joint single-nucleus chromatin accessibility, transcriptome and guide RNA capture using combinatorial indexing combined with droplet microfluidics to scale throughput and integrate all three modalities. We identify key differentiation genes in a rare pediatric cancer and establish ZNHIT1 as a potential target for cancer reprogramming therapy. - Source: PubMed
Publication date: 2024/11/21
Yan Rachel ECorman AlbaKatgara LylaWang XiaoXue XinheGajic Zoran ZSam RichardFarid MichaelFriedman Samuel MChoo JungwookRaimondi IvanGanesan ShridarKatsevich EugeneGreenfield Jeffrey PDahmane NadiaSanjana Neville E - Mammalian preimplantation development culminates in the formation of a blastocyst that undergoes extensive gene expression regulation to successfully implant into the maternal endometrium. Zinc-finger HIT domain-containing (ZNHIT) 1 and 2 are members of a highly conserved family, yet they have been identified as subunits of distinct complexes. Here, we report that knockout of either Znhit1 or Znhit2 results in embryonic lethality during peri-implantation stages. Znhit1 and Znhit2 mutant embryos have overlapping phenotypes, including reduced proportion of SOX2-positive inner cell mass cells, a lack of Fgf4 expression, and aberrant expression of NANOG and SOX17. Furthermore, we find that the similar phenotypes are caused by distinct mechanisms. Specifically, embryos lacking ZNHIT1 likely fail to incorporate sufficient H2A.Z at the promoter region of Fgf4 and other genes involved in cell projection organization resulting in impaired invasion of trophoblast cells during implantation. In contrast, Znhit2 mutant embryos display a complete lack of nuclear EFTUD2, a key component of U5 spliceosome, indicating a global splicing deficiency. Our findings unveil the indispensable yet distinct roles of ZNHIT1 and ZNHIT2 in early mammalian embryonic development. - Source: PubMed
He Xinjian DorisTaylor Louis FMiao XiaosuShi YingchaoLin XinhuaYang ZhongzhouLiu XinMiao Yi-LiangAlfandari DominiqueCui WeiTremblay Kimberly DMager Jesse