Ask about this productRelated genes to: PHF12 antibody
- Gene:
- PHF12 NIH gene
- Name:
- PHD finger protein 12
- Previous symbol:
- -
- Synonyms:
- PF1, KIAA1523
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2003-05-22
- Date modifiied:
- 2014-11-19
Related products to: PHF12 antibody
Related articles to: PHF12 antibody
- Lung cancer stands as the second most prevalent malignant neoplasm worldwide. Addressing the underlying mechanisms propelling the progression of non-small cell lung cancer is of paramount importance. In this study, we have elucidated the pivotal role of PHF12 in this context. - Source: PubMed
Publication date: 2024/07/29
Kong YiruJiang RongrongZhou HuiGe MengxiLin HaoWang YuYao RongrongWang QingLiang XiaohuaLi JingZhou Xinli - Due to a lack of early diagnosis methods and effective drugs, pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis. DNA methylation, transcriptome expression and gene copy number variation (CNV) have critical relationships with development and progression of various diseases. The purpose of the study was to screen reliable early diagnostic biomarkers and potential drugs based on integrative multiomics analysis. - Source: PubMed
Publication date: 2024/06/27
Ge PengleiWang ZhengfengWang WeiweiGao ZhiqiangLi DingyangGuo HuahuQiao ShishiDang XiaoweiYang HuayuWu Yang - The recent guidelines suggest the use of genome-wide analyses, such as whole exome sequencing (WES), at the beginning of the diagnostic approach for cases with suspected genetic conditions. However, in many realities it still provides for the execution of a multi-step pathway, thus requiring several genetic tests to end the so-called 'diagnostic odyssey'. - Source: PubMed
Publication date: 2023/12/02
Rosina EricaPezzani LidiaApuril ErikaPezzoli LauraMarchetti DanielaBellini MatteoLucca CamillaMeossi CamillaMassimello MartaMariani MilenaScatigno AgneseCattaneo ElisaColombo LorenzoMaitz SilviaCereda AnnaMilani DonatellaSpaccini LuiginaBedeschi Maria FrancescaSelicorni AngeloIascone Maria - SIN3A, a scaffold protein has regulatory functions in tumor biology. Through its Paired amphipathic helix (PAH2) domain, SIN3A interacts with PHF12 (PF1), a protein with SIN3 interaction domain (SID) that forms a complex with MRG15 and KDM5A/B. These components are often overexpressed in cancer. In the present study, we evaluated the role of SIN3A and its interacting partner PF1 in mediating inhibition of tumor growth and invasion in triple negative breast cancer (TNBC). We found profound inhibition of invasion, migration, and induction of cellular senescence by specific disruption of the PF1/SIN3A PAH2 domain interaction in TNBC cells expressing PF1-SID transcript or peptide treatment. Genome-wide transcriptomic analysis by RNA-seq revealed that PF1-SID downregulates several gene sets and pathways linked to invasion and migration. Integrin α6 (ITGA6) and integrin ß1 (ITGB1) and their downstream target proteins were downregulated in PF1-SID cells. We further determined increased presence of SIN3A and transcriptional repressor, KLF9, on promoters of ITGA6 and ITGB1 in PF1-SID cells. Knockdown of KLF9 leads to re-expression of ITGA6 and ITGB1 and restoration of the invasive phenotype, functionally linking KLF9 to this process. Overall, these data demonstrate that specific disruption of PF1/SIN3A, inhibits tumor growth, migration, and invasion. Also, PF1-SID not only inhibits tumor growth by senescence induction and reduced proliferation, but it also targets cancer stem cell gene expression and blocks mammosphere formation. Overall, these data demonstrate a mechanism whereby invasion and metastasis of TNBC can be suppressed by inhibiting SIN3A-PF1 interaction and enhancing KLF9 mediated suppression of ITGA6 and ITGB1. - Source: PubMed
Publication date: 2021/12/27
Kadamb RamaLeibovitch Boris AFarias Eduardo FDahiya NishaSuryawanshi HemantBansal NidhiWaxman Samuel - Lung squamous cell carcinoma (LUSC) is one of the commonest malignancies worldwide. Long noncoding RNAs (lncRNAs) have been revealed to engage in cancer development. LncRNA RP11-116G8.5 is a new founded lncRNA that has not been clearly elucidated in LUSC. - Source: PubMed
Publication date: 2021/07/30
Li HongqingZhao QingTang Zhonghao