Ask about this productRelated genes to: ZNF429 antibody
- Gene:
- ZNF429 NIH gene
- Name:
- zinc finger protein 429
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 19p12
- Locus Type:
- gene with protein product
- Date approved:
- 2003-04-25
- Date modifiied:
- 2015-09-29
Related products to: ZNF429 antibody
Related articles to: ZNF429 antibody
- : Hepatoblastoma (HB) is a rare pediatric liver cancer. Complete resection and chemotherapy are standard treatments, but many patients in developing countries present with unresectable tumors and show poor responses to conventional chemotherapy. Identifying somatic alterations in HB may help develop targeted molecular therapies. : Exome sequencing was conducted on 34 HB patient samples to identify somatic mutations and copy number variations (CNVs) and to evaluate their relationships with clinical outcomes, including survival. : HB tumors showed a low mutational burden but a high rate of CNVs, averaging 181.5 CNVs compared to 3.6 somatic mutations per tumor. CNVs were enriched in pathways involved in transcription, differentiation, and development. The most common alterations were missense mutations in (18%), (12%), and (3%). mutations occurred more frequently than mutations in this cohort. Patients with or mutations generally had better overall survival and longer disease-free intervals. Deletions of or were linked to shorter survival in the cohort. Validation with an external dataset confirmed significant downregulation of expression in HB samples, correlating with poorer survival. : This study broadens the understanding of somatic alterations in HB patients, offering insights into the molecular mechanisms behind HB development and highlighting the potential of CNV profiling and deletions as prognostic factors in HB. - Source: PubMed
Publication date: 2026/04/15
Udomwimonsit RinrabhatNokchan NatakornChoochuen PongsakornKlaewtanong YanisaSangkhathat SurasakSirichamratsakul Kulpreeya - Coronary heart disease (CHD) is an intricate and multifaceted cardiovascular disorder that contributes significantly to global morbidity and mortality. Early and accurate identification and diagnosis of CHD are paramount to ensuring patients receive optimal therapeutic interventions and satisfactory outcomes. - Source: PubMed
Wang HaoWu BoHe XueqinLi WeiGuan Wenqi - The high prevalence of autoimmune hypothyroidism (AIHT) - more than 5% in human populations - provides a unique opportunity to unlock the most complete picture to date of genetic loci that underlie systemic and organ-specific autoimmunity. Using a meta-analysis of 81,718 AIHT cases in FinnGen and the UK Biobank, we dissect associations along axes of thyroid dysfunction and autoimmunity. This largest-to-date scan of hypothyroidism identifies 418 independent associations (p < 5×10), more than half of which have not previously been documented in thyroid disease. In 48 of these, a protein-coding variant is the lead SNP or is highly correlated (r > 0.95) with the lead SNP at the locus, including low-frequency coding variants at as well as established variants at and . The variants at (P67T), (T155M), and (Q655X) are highly enriched in Finland and functional experiments in T-cells demonstrate that the :T155M allele reduces T-cell activation. By employing a large-scale scan of non-thyroid autoimmunity and a published meta-analysis of TSH levels, we use a Bayesian classifier to dissect the associated loci into distinct groupings and from this estimate, a significant proportion are involved in systemic (i.e., general to multiple autoimmune conditions) autoimmunity (34%) and another subset in thyroid-specific dysfunction (17%). By comparing these association results further to other common disease endpoints, we identify a noteworthy overlap with skin cancer, with 10% of AIHT loci showing a consistent but opposite pattern of association where alleles that increase the risk of hypothyroidism have protective effects for skin cancer. The association results, including genes encoding checkpoint inhibitors and other genes affecting protein levels of PD1, bolster the causal role of natural variation in autoimmunity influencing cancer outcomes. - Source: PubMed
Publication date: 2024/07/08
Reeve MaryKanai MasahiroGraham DanielKarjalainen JuhaLuo ShuangKolosov NikitaAdams CameronRitari JarmoKarczewski KonradKiiskinen TuomoFuller ZacharyMehtonen JuhaKurki MitjaKhan ZiaPartanen JukkaMcCarthy MarkArtomov MykytaTuomi TiinamaijaPirinen MattiKero JukkaXavier RamnikDaly MarkRipatti SamuliGen Finn - Small cell lung cancer (SCLC) is the most aggressive lung cancer subtype, with more than 70% of patients having metastatic disease and a poor prognosis. However, no integrated multi-omics analysis has been performed to explore novel differentially expressed genes (DEGs) or significantly mutated genes (SMGs) associated with lymph node metastasis (LNM) in SCLC. - Source: PubMed
Publication date: 2023/02/13
Kong KangleHu ShanYue JiaqiYang ZihengJabbour Salma KDeng YuZhao BoLi Fan - Despite experiencing a significant trauma, only a subset of World Trade Center (WTC) rescue and recovery workers developed posttraumatic stress disorder (PTSD). Identification of biomarkers is critical to the development of targeted interventions for treating disaster responders and potentially preventing the development of PTSD in this population. Analysis of gene expression from these individuals can help in identifying biomarkers of PTSD. We established a well-phenotyped sample of 371 WTC responders, recruited from a longitudinal WTC responder cohort using stratified random sampling, by obtaining blood, self-reported and clinical interview data. Using bulk RNA-sequencing from whole blood, we examined the association between gene expression and WTC-related PTSD symptom severity on (i) highest lifetime Clinician-Administered PTSD Scale (CAPS) score, (ii) past-month CAPS score, and (iii) PTSD symptom dimensions using a 5-factor model of re-experiencing, avoidance, emotional numbing, dysphoric arousal and anxious arousal symptoms. We corrected for sex, age, genotype-derived principal components and surrogate variables. Finally, we performed a meta-analysis with existing PTSD studies (total N = 1016), using case/control status as the predictor and correcting for these variables. We identified 66 genes significantly associated with total highest lifetime CAPS score (FDR-corrected p < 0.05), and 31 genes associated with total past-month CAPS score. Our more granular analyses of PTSD symptom dimensions identified additional genes that did not reach statistical significance in our analyses with total CAPS scores. In particular, we identified 82 genes significantly associated with lifetime anxious arousal symptoms. Several genes significantly associated with multiple PTSD symptom dimensions and total lifetime CAPS score (SERPINA1, RPS6KA1, and STAT3) have been previously associated with PTSD. Geneset enrichment of these findings has identified pathways significant in metabolism, immune signaling, other psychiatric disorders, neurological signaling, and cellular structure. Our meta-analysis revealed 10 genes that reached genome-wide significance, all of which were downregulated in cases compared to controls (CIRBP, TMSB10, FCGRT, CLIC1, RPS6KB2, HNRNPUL1, ALDOA, NACA, ZNF429 and COPE). Additionally, cellular deconvolution highlighted an enrichment in CD4 T cells and eosinophils in responders with PTSD compared to controls. The distinction in significant genes between total lifetime CAPS score and the anxious arousal symptom dimension of PTSD highlights a potential biological difference in the mechanism underlying the heterogeneity of the PTSD phenotype. Future studies should be clear about methods used to analyze PTSD status, as phenotypes based on PTSD symptom dimensions may yield different gene sets than combined CAPS score analysis. Potential biomarkers implicated from our meta-analysis may help improve therapeutic target development for PTSD. - Source: PubMed
Publication date: 2022/02/17
Marchese ShelbyCancelmo LeoDiab OliviaCahn LeahAaronson CindyDaskalakis Nikolaos PSchaffer JamieHorn Sarah RJohnson Jessica SSchechter ClydeDesarnaud FrankBierer Linda MMakotkine IouriFlory Janine DCrane MichaelMoline Jacqueline MUdasin Iris GHarrison Denise JRoussos PanosCharney Dennis SKoenen Karestan CSouthwick Steven MYehuda RachelPietrzak Robert HHuckins Laura MFeder Adriana