Ask about this productRelated genes to: Pigs antibody
- Gene:
- PIGS NIH gene
- Name:
- phosphatidylinositol glycan anchor biosynthesis class S
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 17q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-27
- Date modifiied:
- 2016-10-05
Related products to: Pigs antibody
Related articles to: Pigs antibody
- Proper spindle orientation is essential for organogenesis and tissue homeostasis. Cortical tethering complexes, such as the Gαi-LGN-NuMA complex, anchor astral microtubules to guide spindle orientation. However, how astral microtubule stability is coupled to mitosis-dependent regulatory mechanisms remains unclear. Here, we identified suppressor APC domain-containing 2 (SAPCD2) as a cell cycle-regulated factor that functionally links astral microtubule stability to spindle orientation control, utilizing non-polarized HeLa and HaCaT cell culture models. Live-cell imaging revealed that siRNA-mediated depletion of SAPCD2 induces spindle misorientation, leading to mitotic delay and aberrant cell division. Mechanistically, SAPCD2 acts as a previously uncharacterized microtubule-associated protein that promotes microtubule stability, whereas CDK1-mediated phosphorylation at S157, together with phosphorylation at S276, generates a mitosis-specific phosphorylated isoform that destabilizes astral microtubules. Importantly, disruption of SAPCD2 phosphorylation at both S157 and S276 fails to rescue the spindle misorientation caused by SAPCD2 depletion. These findings deepen our understanding of how mitosis-dependent dynamic phosphorylation of microtubule-associated proteins orchestrates astral microtubule behavior to ensure accurate spindle orientation. - Source: PubMed
Publication date: 2026/05/18
Chen ShuangHong YingFang YapingLi MingxuanXia JianhongWen JikaiDai FeiyangLi YuekaiBu WandiHuen Michael S YJiang JunDeng Yiqun - Adipose tissue, a core organ for energy metabolism and body temperature regulation in homeothermic animals, plays a crucial role in the thermogenesis under cold exposure and in maintaining energy homeostasis. Lipid droplets (LDs) are dynamic organelles within adipocytes that store lipids and participate not only in energy storage but also in the precise regulation of thermogenesis via their surface proteins, interactions with mitochondria, and multiple signaling pathways. This article systematically reviews the molecular regulatory mechanisms of LDs in adipose tissue thermogenesis, including the LD structure and function, the classification and characteristics of thermogenic adipose tissues (brown and beige fat), LD-associated proteins (e.g., PLIN and CIDE families), LD-mitochondria interactions, the molecular network (encoding genes and non-coding RNAs) regulating lipid droplet dynamics and adipose thermogenesis, and signaling pathways such as AMPK and mTOR. The review aims to provide theoretical insights for further understanding of energy metabolism mechanisms, cold resistance breeding, and interventions for metabolic diseases. - Source: PubMed
Publication date: 2026/05/13
Feng FenGao XiaoliGun ShuangbaoYang Qiaoli - Ovarian aging in laying hens contributes significantly to the decline in egg production performance during the late laying period, and is accompanied by extensive remodeling of miRNA-mRNA interaction networks, which are critical post-transcriptional regulators during this process. In this study, we investigated the role of miR-30e-3p, which was previously identified as significantly upregulated during ovarian aging in laying hens, in granulosa cell (GC) senescence. To identify its downstream effectors, we performed mRNA transcriptome sequencing and screened for downregulated genes. Among potential targets, the histone methyltransferase complex regulatory subunit dpy-30 (DPY30) was validated as a direct target of miR-30e-3p by luciferase reporter and expression analyses. Functional assays demonstrated that miR-30e-3p significantly suppressed GC proliferation and induced cell cycle arrest, whereas DPY30 exhibited opposite effects. Furthermore, inhibition of miR-30e-3p or overexpression of DPY30 attenuated D-galactose (D-gal) -induced GC senescence. Mechanistically, miR-30e-3p promoted cellular senescence at least in part through downregulation of DPY30. Collectively, our findings indicated that miR-30e-3p promotes GC senescence by targeting DPY30 in chicken ovarian follicles, and suggest that both miR-30e-3p and DPY30 may serve as potential biomarkers for improving reproductive longevity and mitigating ovarian aging-related disorders in poultry. - Source: PubMed
Publication date: 2026/05/07
Wei YuanhangWang YixuanLiao ChimeiCui CanZhang YaoLi ZhuanjianSun CongjiaoZhu QingYin Huadong - This study tested whether sexual dimorphism in the adult guinea pig right pelvic bone is expressed as differences in centroid size, landmark-based shape, and allometric pattern using computed tomography-derived three-dimensional models. A total of 31 adult guinea pigs were initially available, but one female specimen was identified as a marked centroid-size outlier and excluded from inferential analyses; the final analytical sample therefore comprised 11 females and 19 males. Ten fixed landmarks were analyzed on Procrustes-aligned coordinates exported from the landmarking workflow. Centroid size was compared between sexes, raw shape variation was assessed with permutation-based Procrustes ANOVA and principal component analysis, allometry was tested by multivariate regression of shape on log centroid size, and size-corrected shape differences were examined from regression residuals. Males had significantly larger centroid sizes than females (Welch t-test, p = 0.0008). Raw shape differed significantly by sex (F = 14.50, R = 0.341, p = 0.0001). The first two principal components explained 40.09% and 15.16% of the total raw shape variance, respectively. Allometry was significant, but the size-by-sex interaction was not (F = 1.61, p = 0.0958), indicating a broadly shared allometric trend in both sexes. After removal of the allometric component, sex-related shape differences remained significant (F = 6.12, R = 0.179, p = 0.0001). These findings show that pelvic dimorphism in the guinea pig pelvic bone reflects both size-dependent and size-independent components of variation. - Source: PubMed
Publication date: 2026/05/16
Öztürkler OlcayDeveci Emine İremUğur Aslıhan BaykalManuta NicoletaGüzel Barış CanJanuzi VezirAslan DuyguDuro Sokol - Real-time pulmonary artery (PA) stenting under magnetic resonance imaging (MRI) guidance may eliminate radiation exposure during complex vascular interventions. This study evaluated the feasibility of performing PA stenting in a swine model using a commercially available 0.55-T MRI system with ferumoxytol-enhanced imaging. Ten juvenile pigs underwent attempts at MRI-guided PA stent deployment using stainless-steel balloon-expandable stents. Stenting was successful in 7 animals, with all successes achieved after switching from femoral to external jugular venous access. Real-time gradient echo imaging provided sufficient visualization for catheter navigation, device delivery, and stent deployment. Postdeployment phase contrast imaging demonstrated flow continuity, minimal artifact, and trivial pressure gradients across the stent (0.2 ± 0.12 mm Hg). Peak velocities increased by 21.2 ± 7.0 cm/s distal to the stent, confirming preserved patency. These findings demonstrate the technical feasibility of CMR-guided PA stenting at 0.55-T and support the potential for future radiation-free PA interventions. - Source: PubMed
Publication date: 2026/05/18
Liu YixuanKelly John MSwinning JasonLiu YingminJoseph MatthewJin NingPang JianingMaier FlorianKrafft Axel JOoms Nathan ARoll JesseKrieger JoshuaGross David CBramwell Orvillede Mos LucienBorm PaulSimonetti Orlando PArmstrong Aimee K