Ask about this productRelated genes to: Tmem147 antibody
- Gene:
- TMEM147 NIH gene
- Name:
- transmembrane protein 147
- Previous symbol:
- -
- Synonyms:
- NIFIE14, MGC1936
- Chromosome:
- 19q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 2006-03-31
- Date modifiied:
- 2014-11-19
Related products to: Tmem147 antibody
Related articles to: Tmem147 antibody
- TMEM147, an endoplasmic reticulum (ER) membrane protein, is implicated in lung adenocarcinoma (LUAD) progression, although its precise role remains unclear. To elucidate its function, this study integrated bioinformatics analyses with experimental validation. First, TMEM147 expression was assessed using TCGA and GEO datasets, with validation performed in LUAD cell lines. Survival analysis evaluated its prognostic significance. Subsequently, Gene Ontology (GO)/Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses and single-sample gene set enrichment analysis (ssGSEA) were employed to identify associated functional pathways and interactions within the tumor immune microenvironment. Transcription factor binding predictions and in vitro functional assays (migration, invasion, proliferation) further characterized TMEM147's role. Results indicated that TMEM147 was significantly upregulated in LUAD and correlated with poor outcomes in patients. FLI1 was predicted as a key transcriptional regulator of TMEM147. Furthermore, TMEM147 expression influenced immune cell infiltration profiles and was associated with pathways involved in ribonucleoprotein biogenesis and oxidative phosphorylation (OXPHOS). Importantly, silencing TMEM147 significantly reduced cancer cell migration, invasion, and proliferation. These findings collectively suggest that TMEM147 promotes LUAD progression and holds potential as both a prognostic biomarker and a therapeutic target. - Source: PubMed
Publication date: 2025/09/25
Ding LeiDing Yi - Acute myeloid leukemia (AML) is a highly heterogeneous malignancy originating from prolonged abnormal proliferation of immature myeloid cells. Long non-coding RNAs (lncRNAs) are important regulators of AML progression. TMEM147-AS1 has been reported to be abnormally expressed in AML. This study aimed to further explore the roles of TMEM147-AS1 in AML and the possible mechanism. The expression of TMEM147-AS1 and miR-873-3p and its role in the clinical progression of AML were investigated. The diagnostic and prognostic value of TMEM147-AS1 in AML was assessed. The impacts of TMEM147-AS1 on AML cell function were examined. And the targeting relationship among TMEM147-AS1, miR-873-3p, and ZFX was predicted by databases and verified by dual-luciferase reporter assay. TMEM147-AS1 was upregulated in AML tissues and cell lines. High TMEM147-AS1 expression was significantly related to adverse karyotype, shorter overall survival time, and worse prognosis in AML patients. And TMEM147-AS1 can distinguish AML patients from healthy individuals with relatively high sensitivity and specificity. Furthermore, TMEM147-AS1 targeted miR-873-3p, which further targeted ZFX. TMEM147-AS1 promoted proliferation and inhibited apoptosis of AML cells through downregulating the inhibitory effect of miR-873-3p on ZFX expression. TMEM147-AS1 promotes AML progression via regulating the miR-873-3p/ZFX axis. TMEM147-AS1 is a promising diagnostic and prognostic indicator in AML. - Source: PubMed
Publication date: 2025/10/07
Xu YongWang Yanli - Gastric cancer (GC) is a leading cause of cancer-related deaths due to late diagnosis. Altered glycolytic metabolism, notably the Warburg effect, plays a critical role in tumorigenesis, offering potential for early detection and targeted therapy. - Source: PubMed
Publication date: 2025/08/25
Xu YifanZhang ChonghuiWu JinpengQiu MingyangZhu MengWang ChaoFeng Yugong - Radiotherapy sensitivity is associated with the prognosis of patients with tongue squamous cell carcinoma (TSCC). In the present study, we proposed to explore the specific mechanism of interventional radiology (IR) therapy for TSCC in vitro and in vivo. TSCC cells were treated with 6 Gy IR and tumor bearing mice were treated with 20 Gy × 1 IR. DIA quantitative proteomics along with bioinformatics analysis were conducted in TSCC cells to investigate differential proteins related to IR and relation of which involved in TMEM147 and SPHK1 was confirmed by immunoprecipitation. Cell proliferation, apoptosis, autophagy& autophagy flux along with calcium signaling pathway detection were performed in vitro and in vivo. Our results showed that IR induced increasing calcium levels accompanied by up-regulated TMEM147 and down-regulated SPHK1 along with enhancing autophagy together with apoptosis. The effect of calcium overloading induced by IR on autophagy and apoptosis was dependent on increasing TMEM147 and decreasing SPHK1. However, IR-induced autophagy and apoptosis tended to be independent of only increasing calcium levels when down-regulating TMEM147 or up-regulating SPHK1 expression in vitro and in vivo. Our study suggested that calcium-mediated TMEM147/SPHK1 may promote autophagy and apoptosis to improve radiotherapy sensitivity in TSCC. - Source: PubMed
Publication date: 2024/11/29
Hu SonglingLi XiaofeiYang BinYu TianYi FangyuQin XiurongChen CongWang CanYu XinZhu Jing - This research aimed to probe the expression of long noncoding RNA TMEM147 antisense RNA 1 (TMEM147-AS1)/micro-RNA (miR)-124/signal transducer and activator of transcription 3 (STAT3) axis in estrogen receptor (ER)-positive breast cancer (BC). - Source: PubMed
Publication date: 2024/08/07
Liang WeiZhang XuanchangZhang JiaXia HaiyanWei Xiaowei