Ask about this productRelated genes to: Zdhhc11 antibody
- Gene:
- ZDHHC11 NIH gene
- Name:
- zinc finger DHHC-type containing 11
- Previous symbol:
- -
- Synonyms:
- ZNF399, FLJ13153
- Chromosome:
- 5p15.33
- Locus Type:
- gene with protein product
- Date approved:
- 2002-08-28
- Date modifiied:
- 2016-10-05
Related products to: Zdhhc11 antibody
Related articles to: Zdhhc11 antibody
- We previously showed that ZDHHC11 promotes cell growth in Burkitt lymphoma (BL). To explore the underlying mechanism, we performed a genome-wide gene expression analysis upon ZDHHC11 knockdown. We identified MEF2B, a transcription factor critical for germinal center formation, as a downstream target and validated repression of MEF2B at the RNA and protein level upon ZDHHC11 knockdown in BL cell lines. The relevance of MEF2B was shown upon its knockdown, which strongly inhibited growth of BL cells. Since MEF2B is a known regulator of BCL6 in normal GC B-cells, diffuse large B-cell lymphoma, and follicular lymphoma, we subsequently focused on the effect of MEF2B knockdown on BCL6. We observed a strong decrease in BCL6 at the RNA and protein level in BL and showed a strong correlation between MEF2B and BCL6 transcript levels in a panel of B-cell lymphoma cell lines, primary BL samples, and normal B-cell subsets. Knockdown of BCL6 also strongly inhibited growth of BL cell lines, whereas BCL6 overexpression partially rescued the growth-inhibitory effect of MEF2B knockdown. Together, our data indicate that ZDHHC11 promotes BL cell growth at least in part by stimulating expression of MEF2B, which promoted BL cell survival through both BCL6-dependent and independent pathways. Our work highlighted the importance of the MEF2B-BCL6 axis, which strongly supports BL growth and identified ZDHHC11 as a novel regulator of this axis. - Source: PubMed
Publication date: 2026/04/16
Ziel-Swier Lotteke J Y MRassek KarolinaLiu YichenSeitz AnnikaKoerts Jasperde Jong DeboraRutgers BeaKompaniiets AnastasiiaPrzybył JuliaChamuleau Martine E Dvan den Berg AnkeDzikiewicz-Krawczyk AgnieszkaKluiver Joost - Interferon-based local therapy is an intervention for high-risk human papillomavirus (HR-HPV)-associated low-grade squamous intraepithelial lesions (LSIL) or lower-grade cervical abnormalities. This study sought to delineate the differences in clinical outcomes following interferon-based local drug treatment and elucidate the microenvironmental factors driving these disparities. - Source: PubMed
Publication date: 2026/03/10
Ji LingyunWu JingZhou YangPu XiaowenWang XiaoXu BowenJiao RuixianWu WenjuanZhang Wenhong - The comorbid state of obstructive sleep apnea (OSA) and coronary artery disease (CAD) has emerged as a significant public health challenge. However, the underlying metabolic regulation and molecular biomarkers linking to the CAD and OSA comorbidity (CADOSA) remain poorly understood. This study aimed to identify non-invasive biomarkers for the CADOSA comorbidity. - Source: PubMed
Publication date: 2026/03/10
Chen ShuhanLiu QingquanLiu JingZheng HuijuanLi WanqiYu Liying - Palmitoylation, a key post-translational modification, plays a crucial role in tumor progression, yet its landscape in clear cell renal cell carcinoma (ccRCC) remains poorly characterized. This study aims to systematically identify and validate key palmitoylation-modifying enzymes in ccRCC and explore their clinical significance. - Source: PubMed
Publication date: 2026/01/10
Li GuanduZhuge YiduoXu XinruiWang JianhuaZheng ZunwenChe XiangyuZheng XuQi XiaochenWu Guangzhen - In mammals, the activation of stimulator of interferon gene (STING), a pivotal adaptor protein mediating type I interferon (IFN-I) induction upon DNA virus infection, is regulated by palmitoylation. This post-translational modification is catalyzed by zinc finger DHHC domain-containing palmitoyltransferases (ZDHHCs). However, the specific palmitoyltransferases accountable for mediating STING palmitoylation remain predominantly unknown. This study demonstrated that ZDHHC11 plays a critical role by modifying STING palmitoylation and subsequently enhancing the antiviral response in zebrafish. The expression of zebrafish ZDHHC11 was found to be upregulated upon stimulation with GCRV, SVCV, B-DNA, and Z-DNA in the tested tissues or cells. Consistently, the overexpression of zebrafish ZDHHC11 led to an increase in IFN-I expression, while its knockdown resulted in a suppression of IFN-I expression. Mechanistically, ZDHHC11 specifically bound to STING at the endoplasmic reticulum (ER) and then promoted STING palmitoylation via its palmitoyltransferase activity thereby activating the STING-IRF3-mediated IFN I response. In addition, we have demonstrated that ZDHHC11 is capable of inhibiting SVCV replication both in vitro and in vivo. In conclusion, our findings revealed a novel role for ZDHHC11 in regulation of antiviral response. This implies that ZDHHC11 serves as a valuable target for modulating STING signaling and for the development of antiviral therapies. - Source: PubMed
Publication date: 2025/12/30
Yu TingtingLi MeifengZhang HongyingHu JihuanLi MiaomiaoZhang QuanlingLiu XuefengFu ZhixinHu ChengyuXu Xiaowen