Ask about this productRelated genes to: GRAMD3 antibody
- Gene:
- GRAMD2B NIH gene
- Name:
- GRAM domain containing 2B
- Previous symbol:
- GRAMD3
- Synonyms:
- NS3TP2, FLJ21313
- Chromosome:
- 5q23.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-11-03
- Date modifiied:
- 2019-02-21
Related products to: GRAMD3 antibody
Related articles to: GRAMD3 antibody
- Pancreatic islets maintain glucose homeostasis through coordinated action of endocrine and affiliate cell types and are central to type 2 diabetes (T2D) genetics and pathophysiology. Our understanding of robust human islet cell type-specific alterations in T2D remains limited. Here, we report comprehensive single-cell transcriptome profiling of 245,878 human islet cells from 48 donors spanning non-diabetic, pre-diabetic, and T2D states, and we identify 14 distinct cell types detected in every donor. Cell-cluster analysis reveals ~25-30% β-cell reductions consisting of β-cell loss and proportional increases in a senescent β-cell subpopulation in T2D donors, consistent with previous reports. Further, comparative data integration identifies 511 differentially expressed genes (DEGs) in T2D β-cells, including T2D-associated vitamin A metabolism genes, which are linked to impaired β-cell viability by multimodal functional validation. Integration with T2D genetic, proteomic, and mouse model metabolic phenotypes nominates 58 candidate causal T2D genes, including PDZK1 and GRAMD2B, which preserve β-cell mass. Together, this genomic resource provides an enhanced type 2 diabetes expression-atlas for data exploration, analysis, and hypothesis testing, as well as a novel genomic resource for insights into T2D pathophysiology and human islet dysfunction. - Source: PubMed
Publication date: 2026/04/15
Bandesh KhushdeepMotakis EfthymiosNargund SiddhiKursawe RomySelvam VijayAnsarullah Bhuiyan Redwan MEryilmaz Giray NaimWillett Amelia MWhite Jacqueline KKrishnan Sai NiveditaSpracklen Cassandra NUcar DuyguStitzel Michael L - Benign prostatic hyperplasia (BPH) is a common urological condition affecting middle-aged and elderly men, and it significantly impairs their quality of life. Although metabolic disorders are suspected to contribute to BPH, the causal relationship between metabolic markers and BPH remains unclear due to the limitations of traditional observational studies. - Source: PubMed
Publication date: 2026/04/13
Zhou PengfeiZhu Zaisheng - Diabetes is a known risk factor for coronary artery disease (CAD). There is accumulating evidence that CAD pathogenesis differs for individuals with type 1 diabetes (T1D). However, the genetic background has not been extensively studied. We aimed to discover genetic loci increasing CAD susceptibility, especially in T1D, to examine the function of these discoveries and to study the role of the known risk loci in T1D. - Source: PubMed
Antikainen Anni A VSandholm NiinaTrégouët David-AlexandreCharmet RomainMcKnight Amy JayneAhluwalia Tarunveer SSyreeni AnnaValo ErkkaForsblom CarolGordin DanielHarjutsalo ValmaHadjadj SamyMaxwell Alexander PRossing PeterGroop Per-Henrik