Ask about this productRelated genes to: XYLT1 antibody
- Gene:
- XYLT1 NIH gene
- Name:
- xylosyltransferase 1
- Previous symbol:
- -
- Synonyms:
- XT-I, PXYLT1
- Chromosome:
- 16p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-04-06
- Date modifiied:
- 2016-10-05
Related products to: XYLT1 antibody
Related articles to: XYLT1 antibody
- - Source: PubMed
Publication date: 2026/04/11
Li DingruChen ZeruiLiang HerongLi QiangMao XiaofanZhang BeiyingGu WeiquanXiao YeXiong Xing-DongZhou DanDeng YuhuaCai Mengyun - Cattle domestication and subsequent breed formation have profoundly shaped agricultural economies and ecological adaptation worldwide. Among these, Chinese indigenous breeds exhibit extensive phenotypic diversity driven by complex admixture histories. Hetian cattle, a native population from the arid Xinjiang Province of China, possess superior traits including drought tolerance and disease resistance. Despite their ecological and agricultural importance, the genomic architecture and adaptive mechanisms underpinning these traits remain poorly characterized. - Source: PubMed
Publication date: 2025/11/26
Liu XueweiLiu TianyongWang YihuaDong HongLi FuqiangQi XingshanLuo YongmingJiang YiAhmed ZulfiqarLei ChuzhaoGuo Xiang - Periodontitis is a multifactorial inflammatory disease whose pathogenesis is associated with intricate interactions between genetic and environmental factors. Leveraging electronic health records data from the All of Us Research Program, we stratified periodontitis by clinically relevant dimensions: stage, grade, and extent. Based on these phenotypes, we performed a multi-ancestry genome-wide association study, focusing on predominant ancestry populations of African, European, and Admixed American. Our study cohort comprised 3,881 periodontitis patients and a control group of 10,760 patients with dental caries and without periodontitis. Ancestry-specific GWAS revealed significant genetic associations (P<5×10) in periodontitis grade phenotypes at the LINC00294 and CLMN loci in the African ancestry population and also confirmed via the multi-ancestry meta-analysis. In addition, the XYLT1 locus emerged as a significant signal associated with periodontitis grade phenotype in the admixed American GWAS. Our GWAS comparing periodontitis to dental caries in the admixed American population identified several significant loci, including RABGAP1L, previously linked to immune regulation, DCHS2, a cadherin-related gene involved in bone mineralization and tissue morphogenesis, and OSTM1, known to be crucial for bone remodeling. The findings of our study highlight the potential of integrating EHR and genomic data from large-scale biobanks to achieve informative dental phenotyping, uncover novel molecular insights into periodontal disease, and personalize treatment approaches. - Source: PubMed
Publication date: 2025/09/08
Sanders KeithNaseri ArdalanLee Chun-TehIwata JunichiHe YixuanTokede BunmiWalji MuhammadZhi DeguiRasmy Laila - Xylosyltransferase-I (XT-I) plays a crucial role in skeletal development and cartilage integrity. An XT-I deficiency is linked to severe bone disorders, such as Desbuquois dysplasia type 2. While animal models have provided insights into XT-I's role during skeletal development, its specific effects on adult bone homeostasis, particularly in human mesenchymal stem cell (hMSC) differentiation, remain unclear. This study investigates how XT-I deficiency impacts the differentiation of hMSCs into chondrocytes, osteoblasts, and adipocytes-key processes in bone formation and repair. The aim of this study was to elucidate for the first time the molecular mechanisms by which XT-I deficiency leads to impaired bone homeostasis. Using CRISPR-Cas9-mediated gene editing, we generated knockdown (KD) hMSCs to assess their differentiation potential. Our findings revealed significant disruption in the chondrogenic differentiation in KD hMSCs, characterized by the altered expression of regulatory factors and extracellular matrix components, suggesting premature chondrocyte hypertrophy. Despite the presence of perilipin-coated lipid droplets in the adipogenic pathway, the overall leptin mRNA and protein expression was reduced in KD hMSCs, indicating a compromised lipid metabolism. Conversely, osteogenic differentiation was largely unaffected, with KD and wild-type hMSCs exhibiting comparable mineralization processes, indicating that critical aspects of osteogenesis were preserved despite the deficiency. In summary, these results underscore XT-I's pivotal role in regulating differentiation pathways within the bone marrow niche, influencing cellular functions critical for skeletal health. A deeper insight into bone biology may pave the way for the development of innovative therapeutic approaches to improve bone health and treat skeletal disorders. - Source: PubMed
Publication date: 2025/07/30
Ly Thanh-DiepSchmidt VanessaKühle MatthiasBöker Kai OliverFischer BastianKnabbe CorneliusFaust-Hinse Isabel - To analyze the ultrasound findings, single nucleotide polymorphism microarray (SNP array) results, pregnancy outcomes, and follow-up information of fetuses with 16p13.11 deletion or duplication. - Source: PubMed
Publication date: 2025/06/19
Luo XiaojinWu LipingSong JinshuangXu JinmaoHuang RuchunNiu HongyanZhou FeiPei YuanyuanLiu WeiqiangWei Fengxiang