Ask about this productRelated genes to: PTP4A3 antibody
- Gene:
- PTP4A3 NIH gene
- Name:
- protein tyrosine phosphatase 4A3
- Previous symbol:
- -
- Synonyms:
- PRL-3, PRL-R, PRL3
- Chromosome:
- 8q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 1999-09-09
- Date modifiied:
- 2019-02-14
Related products to: PTP4A3 antibody
Related articles to: PTP4A3 antibody
- Temporal lobe epilepsy (TLE) is one of the most common types of epilepsy, with frequent seizures often leading to cognitive, emotional, and psychiatric issues. A prominent pathological change associated with TLE is hippocampal sclerosis (HS), characterized by neuronal loss, gliosis, and increased neuron fibre density. However, the pathogenesis of Temporal lobe epilepsy with hippocampal sclerosis (TLE-HS) remains unclear. This study aimed to investigate the abnormal expression and regulatory mechanism of hub genes in TLE-HS. The source data were obtained from the epilepsy dataset (GSE256068) of the Gene Expression Omnibus GEO database. Then, differential expression gene (DEG) analysis and weighted gene coexpression network analysis (WGCNA) were employed to screen for module-related DEGs in TLE-HS, followed by gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Subsequently, these intersected targets were subjected to cross-validation using three machine learning algorithms- LASSO regression, SVM-RFE, and RF, ultimately identifying three hub genes. Finally, CIBERSORT and ssGSEA algorithms were used to analyze the infiltration status of different immune cell populations in TLE-HS patients, followed by assessing the association between hub genes and immune cell populations. The expression of hub genes was determined using RT-qPCR and western blot. Functional experiments were performed using CCK-8, flow cytometry, and special kits. Results indicated that three hub genes, NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 4-like 2 (NDUFA4L2), Protein-tyrosine Phosphatase 4A3 (PTP4A3), and Zinc-alpha-2-glycoprotein (AZGP1), were identified in TLE-HS, which are associated with the infiltration of specific immune cells. Besides, NDUFA4L2 expression was reduced in kainic acid (KA)-induced HT22 cells compared to the other two hub genes. Thus, NDUFA4L2 was selected for this research. Moreover, NDUFA4L2 overexpression alleviated KA‑induced HT22 cell neurotoxicity, apoptosis, oxidative stress, and mitochondrial dysfunction. In conclusion, NDUFA4L2 upregulation could alleviate KA-induced neurotoxicity oxidative stress, which provided a theoretical foundation and a potential therapeutic target for epilepsy. - Source: PubMed
Publication date: 2026/06/08
Yuan HuimianHe WenlongDu BaoshunLi Jianshe - Lactation curve parameters (LCP) are essential in the refinement of dairy cattle breeding programs due to their relationship with the shape of lactation curves and their biological interpretations. In this context, the primary objectives of this study were to perform genome-wide association studies and functional enrichment analyses of various LCP from random regression models based on 3 nonlinear functions (Wood [WD], Wilmink [WL], and Ali-Schaeffer [AS]) in American Holstein cattle. We used 2,754,840 and 1,642,653 daily milk yield records of 11,139 first and 6,735 s parity cows, respectively, born between 2012 and 2019. A total of 14,464 animals were also genotyped with 60,277 single nucleotide polymorphisms (SNP). The SNP effects, the proportion of the total additive genetic variance explained by them, and their approximate P-values, were estimated for the random regression coefficients based on the GBLUP method. Significant SNP were identified using a modified Bonferroni multiple testing correction that accounts for the number of independent chromosomal segments. Genes and quantitative trait loci located within 100 kb upstream or downstream of the significant SNP were then examined, and functional enrichment analyses were conducted on the candidate genes identified for each LCP. For first parity cows, 81, 128, and 196 significant SNP were identified for the WD, WL, and AS parameters, respectively; whereas for second-parity cows, 120, 125, and 128 significant SNP were identified for the same parameters. The significant SNP were located on 18 autosomal chromosomes. One genomic region (BTA14: 1,801,116 bp) was common to all the parametric functions (WD, WL, and AS). The genomic markers located on BTA15 and BTA19 were unique to the WL parameters; whereas those located on BTA3 and BTA20 were unique to the AS parameters. There were significant SNP located on BTA14 capturing more than 1% of the total additive genetic variance. Twenty candidate genes (i.e., ARC, ADGRB1, C8orf90, CYP11B1, DENND3, GML, GPR20, JRK, LY6D, LY6E, LY6L, LYNX1, LYPD2, PSCA, PTK2, PTP4A3, SLURP1, SLC45A4, THEM6, and TSNARE1) were common to all the parametric functions. No significant gene ontology terms were found for the WD parameter c (i.e., decreasing slope parameter after the lactation peak yield) for first parity cows, and for the AS parameters d and f (parameters associated with the increasing slope) for second-parity cows. Previous reports have identified candidate genes within these genomic regions that possess biological functions related to apoptotic and regulation of gene expression, milk production, clinical mastitis, milk lactose, somatic cell score, fat yield, and udder morphology. This study enabled the identification of several candidate genes associated with LCP, enhancing our understanding of the genomic architecture underlying LCP in American Holstein cattle. - Source: PubMed
Publication date: 2026/05/04
Fotso-Kenmogne Patrick RCarneiro Paulo L SSilva Delvan ALázaro Sirlene FAponte Pedro F CCobuci Jaime AOliveira Hinayah RBrito Luiz F - Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus and an important cause of acquired blindness among working-age populations globally. Endothelial cell dysfunction is involved in the elevated diabetic retinal vascular leakage and pathological neovascularization. This study aimed to elucidate the impact of PTP4A3 in endothelial cell dysfunction in DR-related models. PTP4A3 expression was significantly increased in human diabetic retinopathy, and the streptozotocin-induced diabetic (STZ) model and oxygen-induced retinopathy (OIR) model. PTP4A3 overexpression led to excessive proliferation and migration of endothelial cell. Furthermore, PTP4A3 overexpression disrupted endothelial cell barrier function through decreasing Occludin and Claudin-5 expression. The PTP4A3 inhibitor reversed endothelial cell dysfunction induced by PTP4A3 overexpression in vitro, and ameliorated retinal vascular leakage and pathological neovascularization in vivo. Inhibition of PI3K or AKT partly alleviated endothelial cell dysfunction induced by PTP4A3 overexpression. Overall, PTP4A3 contributes to the enhanced proliferation, migration, and permeability of endothelial cells, which is associated with PI3K-AKT signaling pathway activation, thereby promoting retinal vascular leakage and pathological neovascularization. - Source: PubMed
Publication date: 2026/03/18
Gui Yong-KunYan Zhi-XinRen Rui-FangZhu Rui-RuiZhu De-WeiSun Yu-YingZhang Ping - Acute myeloid leukemia (AML)'s treatment and remission remains unsatisfactory. A prognostic risk-scoring model containing seven signature genes (POU3F1, RPGR, PTP4A3, SOCS1, FAM83G, GREB1 and COL2A1), was developed by LASSO-Cox regression analysis. In the training set, the test group, area under the curve values of 1, 3, and 5 years were 0.876, 0.877, 0.937, and 0.974, 0.878, 0.976 respectively, which indicates a good predictive efficacy. In the two external GEO (GSE71014 and GSE6891) datasets, area under the curve values of 1, 3, 5 years were 0.847, 0.857, 0.822, and 0.830, 0.863, 0.891 respectively. Our seven signature genes containing risk-scoring model performed excellently in evaluating the OS of AML patients. - Source: PubMed
Publication date: 2025/12/26
Liu BinZhang JianWang JingWang QianLiu XiaomanSun Hui - This study aims to examine the pro-apoptotic and anti-migratory effects of Berberine in KB-1 oral cancer cells and its role in ferroptosis via glutathione peroxidase4/six-transmembrane epithelial antigen of prostate3 (GPX4/STEAP3) signaling pathway. - Source: PubMed
Publication date: 2025/11/01
Alassiri Saeed